Results 51 to 60 of about 2,702,233 (230)

Molecular and functional characterization of gap junctions in the avian inner ear. [PDF]

, 2006
To analyze the fundamental role of gap junctions in the vertebrate inner ear, we examined molecular and functional characteristics of gap junctional communication (GJC) in the auditory and vestibular system of the chicken.
Nickel, R, Becker, D, Forge, A
core  

Connexin-26-Mutation bei "Keratitis-Ichthyosis-Deafness"-Syndrom (KID-Syndrom) [Connexin 26 mutation and keratitis-ichthyosis-deafness (KID) syndrome]

, 2005
Background: Keratitis-ichthyosis-deafness syndrome (KID syndrome) is an extremely rare disorder. Inheritance is autosomal dominant but many cases occur sporadically following a spontaneous mutation. The cause of KID syndrome are missense mutations of the
Barbara Binder, Raimund Kraschl, Josef Smolle, Hans Christian Hennies, Smolle, J., Hennies, H.C., Binder, B., Kraschl, R.   +7 more
core   +1 more source

Identifying a Csmd3+ Microglial Subpopulation that Drives Cold‐to‐Hot Transition and Immune‐Cure in Glioblastoma

Advanced Science, EarlyView.
The study establishes an immune‐cure (ICu) mouse model based on a TMEMed G422TN‐GBM system that faithfully recapitulates human TMEMed GBM. scRNA‐seq analysis reveals a Csmd3+ microglial subset with innate immune memory (IIM) potential that potently suppresses GBM growth, drives a TME cold‐to‐hot transition, and induces 100% ICu in long‐term survival ...
Hai‐Feng Jiang, Pan‐Pan Gao, Yu‐Wen Du, Li‐Qin Wu, En‐Zhi Yin, Qi An, Ze‐Hua Ding, Jin‐Wen Shi, Ya Shu, Ruoqiao Chen, Feng Liu, Mingfeng Li, Xiao Qian Chen   +12 more
wiley   +1 more source

A novel connexin 26 mutation in a patient diagnosed with keratitis-ichthyosis-deafness syndrome. [PDF]

, 2002
Contains fulltext : 189194.pdf (Publisher’s version ) (Closed access)Keratitis-ichthyosis-deafness syndrome is a rare disorder characterized by erythrokeratoderma, deafness, and keratitis.
Steijlen, P.M., Nahuys, M., Steensel, M.A.M. van, Geel, M. van, Smitt, J.H.   +4 more
core   +2 more sources

Genetic analysis of the connexin-26 M34T variant [PDF]

Journal of Medical Genetics, 2001
Editor—Existing published data cannot conclusively determine if the M34T allele of connexin-26 ( GJB2 ) is a recessive allele causing hearing loss. The recent article by Houseman et al ( J Med Genet 2001; 38 :20-5) “Genetic analysis of the connexin-26 M34T variant: identification of genotype M34T/M34T segregating with mild-moderate non-syndromic ...
openaire   +2 more sources

Mutation analysis of the GJB2 (Connexin 26) gene in Egypt [PDF]

Human Mutation, 2005
Fifty to eighty percent of autosomal recessive deafness is due to mutations in the GJB2 gene encoding connexin 26. Among Caucasians, the c.35delG mutation in this gene accounts for up to 30 to 70% of all cases with early childhood deafness. In this study, we present the analysis of the GJB2 gene in 159 Egyptians from 111 families with non-syndromic ...
Snoeckx, Rikkert L., Hassan, Dalia M., Kamal, Nadia M., van den Bogaert, Kris, Van Camp, Guy   +4 more
openaire   +3 more sources

Studies of intercellular Ca2+ signaling and gap-junction coupling in the developing cochlea of mouse models affected by congenital hearing loss [PDF]

, 2013
Connexin 26 (Cx26) and connexin 30 (Cx30) form gap junction channels that allow the intercellular diffusion of the Ca2+ mobilizing second messenger IP3.
Rodriguez Hernandez, Laura
core  

Functional implications of calcium permeability of the channel formed by pannexin 1. [PDF]

, 2006
Although human pannexins (PanX) are homologous to gap junction molecules, their physiological function in vertebrates remains poorly understood. Our results demonstrate that overexpression of PanX1 results in the formation of Ca(2+)-permeable gap ...
Ivanov, Dmitry, V, Panchin, YV, Vanden Abeele, F, Fabien Vanden Abeele, Panchin, Yuri V, Gordienko, D, Yuri V. Panchin, Baranova, AV, Skryma, R, Baranova, Ancha, V, Skryma, Roman, Gordienko, Dmitri, Gabriel Bidaux, Beck, Benjamin, Ivanov, DV, Prevarskaya, N, Ancha V. Baranova, Baranova, Ancha V, Natalia Prevarskaya, Benjamin Beck, Ivanov, Dmitry V, Panchin, Yuri, Ivanov, Dimitri, Prevarskaya, Natalia, Vanden Abeele, Fabien, Bidaux, G, Bidaux, Gabriel, Dmitry V. Ivanov, Beck, B, Panchin, Yuri, V, Roman Skryma, Dmitri Gordienko   +31 more
core   +1 more source

Entorhinal Astrocyte Transplants Restore Spatial Exploration and Alleviate Amyloid‐Beta Pathology in Alzheimer's Mice

Advanced Science, EarlyView.
Impaired MEC astrocytic Ca2+ signaling is associated with fragmented spatial exploration in AD mice. Region‐specific glial progenitor transplantation generates engrafted astrocytes that are accompanied by improved AQP4 polarization, reduced amyloid‐β‐associated pathology, attenuated neuroinflammation, preserved synaptic integrity, and ameliorated ...
Fengjuan Wu, Jihua Fan, Xiang Zhou, Zhiqi Yang, Mingyue Gong, Mingzhu Huang, Zhenlu Cai, Shaofan Yang, Teng Teng, Chuanyan Yang, Jin Li, Haoyu Wang, Shuangshuang Dai, Chunhai Chen, Xiaowei Chen, Manxia Wang, Kuan Zhang   +16 more
wiley   +1 more source

Connexin-43 Depletion in Tip60-Depleted Hearts.

, 2016
Heart samples were immunostained (A-D) or western blotted (E-F) to detect connexin-43. Panels A-D reveal that progressively diminished expression in the intercalated disc transverse component occurs between weeks 4 and 8.
John Lough (17777), Tina Wan (183965), John Auchampach (183974), Min-Su Kim (183958), Joseph B. Fisher (183954), Audrey Horst (695093)   +5 more
core   +1 more source