Results 101 to 110 of about 8,250 (205)

Silencing GJB2 attenuates IL-1β-induced chondrocyte injury by activating Nrf2/HO-1 signaling and preserving mitochondrial function

Folia Histochemica et Cytobiologica
INTRODUCTION: Mitochondrial oxidative stress is a key driver of inflammation-induced chondrocyte dysfunction and cartilage degeneration. However, the molecular regulators linking inflammatory signaling to mitochondrial impairment in chondrocytes remain ...
Hongyi Pan, Lianguo Wu
doaj   +1 more source

Analysis of hearing thresholds in patients with hearing impairments associated with mutations of the GJB2 gene (Sh26) in Buryatia

Якутский медицинский журнал
In this work, the hearing analysis of 26 patients with hearing impairment, who had biallelic mutations of the GJB2 gene (Sh26) was carried out in the Republic of Buryatia.
F. M. Teryutin, V. G. Pshennikova, G. P. Romanov, A. V. Solovyov, L. A. Klarov, N. A. Lebedeva, N. A. Barashkov   +6 more
doaj   +1 more source

Absence of mutations in GJB2 (Connexin-26) gene in an ethnic group of southwest Iran [PDF]

, 2010
Background : The common GJB2 gene mutation (35delG) has been previously reported from Iranian patients that were affected with nonsyndromic autosomal recessive deafness.
Galehdari, Hamid, Soorki, Maryam Naderi, Mohammadian, Gholamreza, Foroughmand, Ali Mohammad   +3 more
core   +2 more sources

The variants and prevalence of the GJB2 and GJB6 in patients with non-syndromic congenital sensorineural hearing loss in Maluku, Indonesia

The Egyptian Journal of Otolaryngology
Background Mutations in the GJB2 (connexin 26) and GJB6 (connexin 30) genes are the most common causes of congenital non-syndromic sensorineural hearing loss.
Rodrigo Limmon, Abdul Qadar Punagi, Masyita Gaffar, Irfan Idris, Handayani Halik   +4 more
doaj   +1 more source

GJB2 mutations and their allele frequencies.

, 2015
GJB2 mutations and their allele frequencies.
Kyu Hee Han (752642), Ah Reum Kim (449120), Byung Yoon Choi (407079), Ja-Won Koo (407076), Eun-Hee Jeon (752643), Min Young Kim (313098), Seung Ha Oh (407078), So Young Kim (253800)   +7 more
core   +1 more source

Viral‐Mediated Connexin 26 Expression Combined with Dexamethasone Rescues Hearing in a Conditional Gjb2 Null Mice Model

Advanced Science
GJB2 encodes connexin 26 (Cx26), the most commonly mutated gene causing hereditary non‐syndromic hearing loss. Cx26 is mainly expressed in supporting cells (SCs) and fibrocytes in the mammalian cochlea.
Xiaohui Wang, Li Zhang, Sen Chen, Le Xie, Yue Qiu, Chenyang Kong, Ge Yin, Weijia Kong, Yu Sun   +8 more
doaj   +1 more source

Comparison of vestibular function in hereditary hearing loss patients with GJB2, CDH23, and SLC26A4 variants

Scientific Reports
To investigate the association between hereditary hearing loss and vestibular function, we compared vestibular function and symptoms among patients with GJB2, SLC26A4, and CDH23 variants.
Keita Tsukada, Shin-ya Nishio, Yutaka Takumi, Shin-ichi Usami   +3 more
doaj   +1 more source

GJB2 Gene [PDF]

, 2020
openaire   +1 more source

GJB2 wt Allele [PDF]

, 2020
openaire   +1 more source

GJB2-related hearing loss in central Iran: Review of the spectrum and frequency of gene mutations [PDF]

, 2019
Mutations in the GJB2 gene are a main cause of autosomal-recessive nonsyndromic hearing loss (ARNSHL) in many populations. Previous studies have estimated the average frequency of GJB2 mutations to be similar to 16% in Iran, but would vary among ...
Koohiyan, Mahbobeh, Koohian, Farideh, Azadegan-Dehkordi, Fatemeh   +2 more
core