Results 161 to 170 of about 304,609 (284)

Therapeutic Gene Editing of APOE4 in Sporadic Alzheimer's Disease via Prime Editor 7

Advanced Science, EarlyView.
Prime Editor 7‐mediated conversion of APOE4 to APOE3 alleviates Alzheimer's disease‐associated pathology in AD mouse models and patient‐derived neurons and improves cognitive performance in vivo, supporting therapeutic genome editing as a promising strategy for APOE4‐associated neurodegeneration.
Yunkyung Kim, Gaeun Lee, Saemin An, Hanseul Park, Hongwon Kim, Jisung Kim, Soi Kang, Sumin Kim, Daeyeol Kwon, Jeonghyun Park, Yerim Hwang, Seonghun Kim, Xiuwen Yuan, Jaehoon Jeong, Hamin Lee, Hui Kwon Kim, Jongpil Kim   +16 more
wiley   +1 more source

Dual recognition drives site-directed G-quadruplex stabilization: Oligonucleotide design in G4 ligand-oligonucleotide conjugates. [PDF]

Mol Ther Nucleic Acids
Abrahamsson A, Khwaja S, Chaudhari N, Vertueux S, Berner A, Aasumets K, Kumar C, Stietz L, Baladi T, Dahlén A, Wanrooij S, Chorell E.   +11 more
europepmc   +1 more source

Cancer‐Associated BCL‐2 Mutants Reveal Mechanisms Towards Venetoclax Resistance

Advanced Science, EarlyView.
Venetoclax (VEN) resistance in chronic lymphocytic leukemia arises from diverse BCL2 mutations. We map mechanisms contributing to VEN resistance across common BCL‐2 variants. G101V and D103Y reduce drug binding and increase sequestration of pro‐apoptotic proteins. V156D blocks VEN allosterically.
Jonas Aufdermauer, Ian de Ridder, Mahjoobeh Ehsani, Marasim Khan, Justin Kale, Lukas P. Frenzel, David Andrews, Spyridoula Karamanou, Ana J. Garcia‐Saez, Geert Bultynck   +9 more
wiley   +1 more source

On Higher Multiplicity upon Restriction from $\mathrm{GL}(n)$ to $\mathrm{GL}(n-1)$ [PDF]

Let $F$ be a non-archimedean local field. Let $Π$ be a principal series representation of $\mathrm{GL}_n(F)$ induced from an irreducible cuspidal representation of a Levi subgroup.
Qadri, Mohammed Saad
core  

Dual Antigen Display on an AP205 VLP Platform Elicits Potent and Durable Neutralization of EBV Infection in B Cells and Epithelial Cells In Vitro. [PDF]

Vaccines (Basel)
Han X, Gao P, Shi Y, Li C, Zhai X, Feng G, Zeng M, Hou B, Song J, Zhang F.   +9 more
europepmc   +1 more source

GL [PDF]

, 2019
openaire   +1 more source

UCtracker: A Deep Learning–Based DNA Methylation Model for Noninvasive Diagnosis and Recurrence Surveillance of Urothelial Carcinoma in a Prospective Study

Advanced Science, EarlyView.
We developed UCtracker, a urine DNA methylation–based deep learning model, for noninvasive diagnosis and postoperative surveillance of urothelial carcinoma. UCtracker demonstrates high diagnostic accuracy, robustness at ultralow sequencing depth, early recurrence detection, and dynamic risk‐stratified monitoring of molecular residual disease ...
Shengwei Xiong, Gaojie Li, Yucai Wu, Yuan Liang, Heng Guo, Yu Zhang, Gengyan Xiong, Long Tian, Xin Zhang, Ye Tian, Zhengguo Ji, Bin Guo, Yue Shi, Jian Fan, Zhihua Li, Yanqing Gong, Shiming He, Xuesong Li, Weimin Ci, Liqun Zhou   +19 more
wiley   +1 more source

Characterization of a <i>β</i>-Glucosidase from <i>Fragaria × ananassa</i>: Substrate Specificity, Catalytic Efficiency, and Structural Insights. [PDF]

Foods
Rabeeah I, Zavarise A, Manghi A, Gruber-Schmidt V, Hackl M, Paltram R, Gössinger M, Cattani L, Stich K, Sheehan H, Halbwirth H, Haselmair-Gosch C.   +11 more
europepmc   +1 more source

Programming Structural Symmetry and Emission in Low‐Dimensional Hybrid Perovskites via Time and Temperature

Advanced Science, EarlyView.
We demonstrate programmable structural symmetry and emission in benzylammonium‐based low‐dimensional hybrid perovskites. Continuous shaking transforms orthorhombic platelets into a lower‐symmetry monoclinic phase with broadband emission, whereas thermal activation drives the reverse pathways toward a higher‐symmetry configuration resembling the ...
Luiz G. Bonato, Sirous Khabbaz Abkenar, Balaji Dhanabalan, Quentin Evrard, Luca Goldoni, Sergio Marras, Giorgio Divitini, Milena P. Arciniegas   +7 more
wiley   +1 more source

Present and past experiences in GL management and research. A questionnaire survery on Italian participants to GL events

, 2007
La diffusione del concetto di Letteratura grigia in Italia si deve principalmente alle iniziative promosse dall'Associazione italiana biblioteche (AIB), la quale nel 1985 costituì un Gruppo di lavoro che si occupava delle problematiche della Letteratura
Ruggieri Roberta, Di Cesare Rosa, Cerbara Loredana   +2 more
core