Results 241 to 250 of about 1,513,313 (316)

Hepatocyte BDNF Acts as a Novel Immune Checkpoint to Restrain TLR4‐Mediated Acute Hepatitis

Advanced Science, EarlyView.
This study identifies hepatocyte‐derived BDNF as an endogenous TLR4 antagonist that alleviates acute hepatitis. BDNF is downregulated in hepatocytes via REST‐mediated transcriptional repression during ALI/ALF. Mechanistically, BDNF binds to TLR4 on macrophages to suppress inflammation.
Weiwei Zhu, Yaqian Cui, Yongqiang Zhou, Yihui Zheng, Lijiang Huang, Leiming Jin, Qianhui Zhang, Pan Chen, Mengsha Lin, Jiaxi Ye, Yongqiang Xiong, Joo Young Huh, Xiang Hu, Xiaokun Li, Wu Luo, Guang Liang   +15 more
wiley   +1 more source

Candidate Gene Identification and Genomic Prediction for Key Reproductive Traits in Yorkshire, Landrace, and Duroc Pigs. [PDF]

Animals (Basel)
Hao W, Sun WS, Li Z, Zhang J, Shi L, Chaolu H, Zhang Q, Kumar Suthar T, Wang L, Zhang SM.   +9 more
europepmc   +1 more source

GL 4

Bischof Konrad I. von Passau bezeugt den Tausch zwischen Abt Friedrich von Seitenstetten und Abt Ulrich von Gleink um genannten Zehnten bzw. Besitz; 1151 Januar – , – .
openaire   +1 more source

First Generation Proteolysis Targeting Chimeras (PROTACs) for the Treatment of Progeria

Advanced Science, EarlyView.
We report the first PROTACs designed to degrade progerin, introducing a novel therapeutic approach for progeria. The best compound, UCM‐18142, significantly reduces progerin levels and improves key disease phenotypes in patient‐derived cells and in the LmnaG609G/G609G mouse model, paving the way for new treatment strategies targeting the root cause of ...
Jon Macicior‐Michelena, Marcelino Telechea, Daniel Fernández, Alba García‐Martín, Ángeles Canales, Silvia Ortega‐Gutiérrez   +5 more
wiley   +1 more source

Quantitative lipidomic analysis of blood and milk in jennies with high and low milk fat content. [PDF]

Vet Anim Sci
Zhang LT, Zhang K, Yan QX, Deng L, Degen A, Liu LL, Zhou XL.   +6 more
europepmc   +1 more source

Vaccination with nanoparticles displaying gH/gL from Epstein-Barr virus elicits limited cross-protection against rhesus lymphocryptovirus [PDF]

Kristina R. Edwards, Karina Schmidt, Leah J. Homad, Gargi Kher, Guoyue Xu, Kristen A. Rodrigues, Elana Ben‐Akiva, Joe Abbott, Martin Prlic, Evan W. Newell, Stephen C. De Rosa, Darrell J. Irvine, Marie Pancera, Andrew T. McGuire   +13 more
openalex   +1 more source

Comparative Oligo‐FISH Mapping Illuminates Chromosomal Evolution Among Rutaceae Species Diverged Over 50 Million Years

Advanced Science, EarlyView.
Oligonucleotide‐based fluorescence in situ hybridization probes were developed in the model citrus species Citrus maxima. These probes were applied to comparative karyotyping across 14 species in the Rutaceae family. This analysis revealed chromosomal evolution in lineages that diverged from Citrus nearly 52 million years ago.
Li He, Hainan Zhao, Xiaoxue Zeng, Zujun Yang, Wenting Li, Guoyan Zhang, Guangrong Li, Jian He, Bin Guan, Jiming Jiang   +9 more
wiley   +1 more source

Insights into the olaparib-mediated cell death mechanisms in canine hematological malignancies: a different fate for CLBL-1 and GL-1 cell lines. [PDF]

Front Vet Sci
Mucignat G, Dejnaka E, Pauletto M, Lopparelli RM, Giantin M, Pawlak A, Dacasto M.   +6 more
europepmc   +1 more source

Parenteral Nanoemulsion for Optimized Delivery of GL-II-73 to the Brain—Comparative In Vitro Blood–Brain Barrier and In Vivo Neuropharmacokinetic Evaluation [PDF]

Kristina Jezdić, Jelena Đoković, Ivan Jančić, Jela Milić, Biljana Bufan, Bojan Marković, Jana Ivanović, Tijana Stanković, Nebojša Cekić, Vassiliki Papadimitriou, Dishary Sharmin, Prithu Mondal, James M. Cook, Snežana Savić, Miroslav M. Savić   +14 more
openalex   +1 more source

Bench‐to‐Bedside Translation of Self‐Healing Colloidal Hydrogels as Next Generation Design of Flowable Hemostatic Matrix: From Preclinical Evaluation to Human Clinical Trials

Advanced Science, EarlyView.
ABSTRACT Self‐healing materials represent a paradigm shift in designing functional biomedical devices for drug delivery, tissue regeneration, and 3D bioprinting. However, their clinical translation remains limited by challenges such as insufficient mechanical strength, potential cytotoxicity from chemical modifications, and complex activation ...
Ganjun Feng, Kaiwen Chen, Qiwei Ying, Shuya Wang, Xin Li, Guanlin Li, Yantao Zhao, Binghua Ma, Huanan Wang, Dawei Li, Lijun Zhang, Jian Zhang, Yu Zhao, Changle Ren, Baodong Chen, Yueming Song   +15 more
wiley   +1 more source