Results 31 to 40 of about 1,512,970 (263)

Generation of induced pluripotent stem cells, KCi001-A derived from a Bardet-Biedl syndrome patient compound heterozygous for the BBS1 variants c.1169T>G/c.1135G>C

open access: yesStem Cell Research, 2018
Bardet-Biedl syndrome (BBS) is an autosomal recessive ciliopathy with a wide range of symptoms including obesity, retinal dystrophy, polycystic kidney disease, polydactyly, hypogonadism and learning difficulties.
Caroline Amalie Brunbjerg Hey   +7 more
doaj   +1 more source

On a class of integrable systems connected with GL(N,\RR)

open access: yes, 2003
In this paper we define a new class of the quantum integrable systems associated with the quantization of the cotangent bundle $T^*(GL(N))$ to the Lie algebra $\frak{gl}_N$. The construction is based on the Gelfand-Zetlin maximal commuting subalgebra in $
A. GERASIMOV   +9 more
core   +2 more sources

Generation of induced pluripotent stem cells, KCi002-A derived from a patient with Bardet-Biedl syndrome homozygous for the BBS10 variant c.271insT

open access: yesStem Cell Research, 2018
Bardet-Biedl syndrome (BBS) is genetically heterogeneous with at least 21 genes involved, and BBS10 encodes, together with BBS6 and BBS12, chaperonin-like proteins which are important for the assembly of the multiprotein complex, the BBSome encoded by ...
Caroline Amalie Brunbjerg Hey   +7 more
doaj   +1 more source

Three results on representations of Mackey Lie algebras

open access: yes, 2014
I. Penkov and V. Serganova have recently introduced, for any non-degenerate pairing $W\otimes V\to\mathbb C$ of vector spaces, the Lie algebra $\mathfrak{gl}^M=\mathfrak{gl}^M(V,W)$ consisting of endomorphisms of $V$ whose duals preserve $W\subseteq V^*$.
E. Dan-Cohen   +3 more
core   +1 more source

Generation and characterization of three isogenic induced pluripotent stem cell lines from a patient with Bardet-Biedl syndrome and homozygous for the BBS5 variant

open access: yesStem Cell Research, 2019
Bardet-Biedl syndrome (BBS), an autosomal recessive disease, is associated with non-functional primary cilia. BBS5 is part of the protein complex termed the BBSome.
Caroline Amalie Brunbjerg Hey   +6 more
doaj   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

open access: yesFEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang   +9 more
wiley   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

open access: yesFEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang   +9 more
wiley   +1 more source

The Algebraic Structure of the $gl(n|m)$ Color Calogero-Sutherland Models

open access: yes, 1997
We extend the study on the algebraic structure of the $su(n)$ color Calogero-Sutherland models to the case of $gl(n|m)$ color CS model and show that the generators of the super-Yangian $Y(gl(n|m))$ can be obtained from two $gl(n|m)$ loop algebras.
Drinfeld V. G.   +3 more
core   +1 more source

On the relationship between climate sensitivity and modelling uncertainty

open access: yesTellus: Series A, Dynamic Meteorology and Oceanography, 2017
Climate model projections are used to investigate the potential impacts of climate change on future weather, agriculture, water resources, human health, the global economy, etc. However, climate projections have a broad range of associated uncertainties,
Cecilie Mauritzen   +2 more
doaj   +1 more source

Characterization of Lignins from Sugarcane Bagasse Pretreated with Green Liquor Combined with Ethanol and Hydrogen Peroxide

open access: yesBioResources, 2016
Sugarcane bagasse was pretreated by green liquor combined with ethanol (GL-Ethanol) and green liquor combined with H2O2 (GL-H2O2). After 72 h of enzymatic hydrolysis, the glucose yields of sugarcane bagasse pretreated with GL-Ethanol and GL-H2O2 were 97 ...
Ziyuan Zhou   +4 more
doaj   +1 more source

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