Results 51 to 60 of about 304,609 (284)

On the relationship between climate sensitivity and modelling uncertainty

Tellus: Series A, Dynamic Meteorology and Oceanography, 2017
Climate model projections are used to investigate the potential impacts of climate change on future weather, agriculture, water resources, human health, the global economy, etc. However, climate projections have a broad range of associated uncertainties,
Cecilie Mauritzen, Tatjana Zivkovic, Vidyunmala Veldore   +2 more
doaj   +1 more source

Chiral separation of chloroalkanes with the chromatographic column onboard Martian rovers

FEBS Letters, EarlyView.
Computer image of the Rosalind Franklin Rover of ESA's ExoMars mission. ExoMars is scheduled to land on planet Mars in Oxia Planum in 2029. This area represents an interesting spot to look for biosignatures. Investigations of ExoMars include measurement on molecular chirality. We show that chiral chloroalkanes, that have been identified on Mars, can be
Asma Merzougui, Agnes Banreti, Armelle L. Ernst, Guillaume Leseigneur, Uwe J. Meierhenrich   +4 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

On Using Grey Literature and Google Scholar in Systematic Literature Reviews in Software Engineering

IEEE Access, 2020
Context: The inclusion of grey literature (GL) is important to remove publication bias while gathering available evidence regarding a certain topic. The number of systematic literature reviews (SLRs) in Software Engineering (SE) is increasing but we do ...
Affan Yasin, Rubia Fatima, Lijie Wen, Wasif Afzal, Muhammad Azhar, Richard Torkar   +5 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Assessing the potential of Moldova’s agri-food products in the context of EU neighbourhood

Agricultural Science, 2014
Due to the Deep and Comprehensive Free Trade Agreement signed recently between Moldova and European Union, it is of vital importance for local agri-food products to be competitive on the EU market in order to benefit from the potential gains of the ...
CIMPOIEŞ Liliana , COŞER Cornel
doaj  

Inconsistencies in the risk classification of alien species and implications for risk assessment in the European Union

Ecosphere, 2017
Invasive alien species (IAS) are species whose introduction or spread outside their native range threatens biological diversity, ecosystem functioning, economy, and/or public health.
J. Matthews, G. van derVelde, F. P. L. Collas, L. de Hoop, K. R. Koopman, A. J. Hendriks, R. S. E. W. Leuven   +6 more
doaj   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Identification of the Uncertainties for the Calibration of the Partial Safety Factors for Load in Tidal Turbines

Journal of Marine Science and Engineering, 2016
Tidal energy is nowadays one of the fastest growing types of marine renewable energy. In particular, Horizontal Axis Tidal Turbines (HATTs) are the most advanced designs and the most appropriate for standardization. This paper presents a review of actual
Gaizka Zarraonandia Simeón, Claudio Bittencourt Ferreira   +1 more
doaj   +1 more source