Results 61 to 70 of about 304,609 (284)

Bridging the gap: a genetically validated avian chorioallantoic membrane platform for investigation of spontaneous circulating tumor cells

open access: yesMolecular Oncology, EarlyView.
We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth   +17 more
wiley   +1 more source

Appendix: The GL(n) pack Manual [PDF]

open access: yes, 2006
This appendix is the manual for a set of functions written to assist the reader to understand and apply the theorems on GL(n, R) set out in the main part of the book.
Broughan, Kevin A.
core  

A Novel Method for Safety Analysis of Cyber-Physical Systems—Application to a Ship Exhaust Gas Scrubber System

open access: yesSafety, 2020
Cyber-Physical Systems (CPSs) represent a systems category developed and promoted in the maritime industry to automate functions and system operations.
Victor Bolbot   +4 more
doaj   +1 more source

Derivatives for smooth representations of GL(n, ℝ) and GL(n, ℂ) [PDF]

open access: yesIsrael Journal of Mathematics, 2015
The notion of derivatives for smooth representations of GL(n) in the p-adic case was defined by J. Bernstein and A. Zelevinsky. In the archimedean case, an analog of the highest derivative was defined for irreducible unitary representations by S. Sahi and called the "adduced" representation.
Aizenbud, A., Gourevitch, D., Sahi, S.
openaire   +3 more sources

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim   +17 more
wiley   +1 more source

Prospects for Ray-tracing Light Intensity and Polarization in Models of Accreting Compact Objects Using a GPU

open access: yesThe Astrophysical Journal Supplement Series, 2023
The Event Horizon Telescope (EHT) has recently released high-resolution images of accretion flows onto two supermassive black holes. Our physical understanding of these images depends on the accuracy and precision of numerical models of plasma and ...
Monika A. Moscibrodzka   +1 more
doaj   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

open access: yesFEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya   +2 more
wiley   +1 more source

To b(gl) or not to b(gl): how cryptic are “cryptic” genes? [PDF]

open access: yesJournal of Biosciences, 1998
A striking feature that has emerged from the genome sequencing projects that have been completed so far is the extremely high coding percentage seen in all bacterial genomes. In the case of Escherichia coli, it is higher than 90% (in higher eukaryotes including humans, it can be as low as 2%). Despite running such a tight ship, many prokaryotic genomes
openaire   +2 more sources

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

open access: yesFEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks   +4 more
wiley   +1 more source

Comparison of multiple and novel measures of dietary glycemic carbohydrate with insulin resistant status in older women

open access: yesNutrition & Metabolism, 2010
Background Previous epidemiological investigations of associations between dietary glycemic intake and insulin resistance have used average daily measures of glycemic index (GI) and glycemic load (GL).
O'Neill Sheila   +3 more
doaj   +1 more source

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