Results 41 to 50 of about 38,745 (258)
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Meitan xuebaoCurrently, global warming driven by anthropogenic factors such as the massive emission of greenhouse gases is gradually transitioning the Earth’s surface climate from a Quaternary glacial period to an interglacial or greenhouse climate, accompanied by ...
Ye WANG +7 more
doaj +1 more source
Southward Migration of Arctic Ocean Species During the Last Glacial Period
Geophysical Research Letters, 2022 The East Asian winter monsoon (EAWM) is associated with northerly surface winds affecting crop and livestock productivity and social and economic activities across East Asia. However, the relationship between EAWM dynamics and marine biota remains poorly
Penghui Zhang +9 more
doaj +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Controls on Alpine Lake Dynamics, Tien Shan, Central Asia
Remote Sensing, 2022 The number and area of alpine lakes in Tien Shan (TS) are rapidly growing in response to a warming climate and retreating glaciers. This paper presents a comparative analysis of lake classification and changes by dividing alpine lakes (within a 10 km ...
Qifei Zhang +5 more
doaj +1 more source
Periodicity of Glacial Epochs [PDF]
Nature, 1886 PERMIT me to ask, as a matter of international comity in science, the help of my learned British colleagues in the following matter.
openaire +1 more source
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Physio-Géo, 2011 Morphometric data from a sample of thirty glacial cirques located in European basement regions (Black Forest, South-West Ireland and Wales) assess the rate of glacial erosion.
Francis Huguet
doaj +1 more source