Results 61 to 70 of about 220,015 (302)

The environmental and evolutionary history of Lake Ohrid (FYROM/Albania). Interim results from the SCOPSCO deep drilling project [PDF]

open access: yes, 2016
This study reviews and synthesises existing information generated within the SCOPSCO (Scientific Collaboration on Past Speciation Conditions in Lake Ohrid) deep drilling project.
Addabbo, Michele   +52 more
core   +14 more sources

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

open access: yesMolecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung   +17 more
wiley   +1 more source

Howden Moss: a study of vegetational history in Upper Teesdale [PDF]

open access: yes, 1976
The peat deposits at Howden Moss, Upper Teesdale, have been examined stratigraphically and pollen analytically. The present state of the bog in described and pollen diagrams are presented for three sites. The results show that peat formation had begun by
Simpson, Caroline Anne
core   +1 more source

Northeastern Atlantic benthic foraminifera during the last 45,000 years: Changes in productivity seen from the bottom up [PDF]

open access: yes, 1995
We studied benthic foraminifera from the last 45 kyr in the >63 mu m size fraction in Biogeochemical Ocean Flux Studies (BOFS) cores 5K (50 degrees 41.3'N, 21 degrees 51.9'W, depth 3547 m) and 14K (58 degrees 37.2'N, 19 degrees 26.2'W, depth 1756 m), at ...
Booth, L   +3 more
core   +1 more source

Association of late Carboniferous wildfire records with interglacial climate change in North China Platform

open access: yesMeitan xuebao
Currently, global warming driven by anthropogenic factors such as the massive emission of greenhouse gases is gradually transitioning the Earth’s surface climate from a Quaternary glacial period to an interglacial or greenhouse climate, accompanied by ...
Ye WANG   +7 more
doaj   +1 more source

Southward Migration of Arctic Ocean Species During the Last Glacial Period

open access: yesGeophysical Research Letters, 2022
The East Asian winter monsoon (EAWM) is associated with northerly surface winds affecting crop and livestock productivity and social and economic activities across East Asia. However, the relationship between EAWM dynamics and marine biota remains poorly
Penghui Zhang   +9 more
doaj   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

open access: yesMolecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang   +3 more
wiley   +1 more source

Potential atmospheric impact of the Toba Mega‐Eruption ∼71,000 years ago [PDF]

open access: yes, 1996
An ∼6‐year long period of volcanic sulfate recorded in the GISP2 ice core about 71,100 ± 5000 years ago may provide detailed information on the atmospheric and climatic impact of the Toba mega‐eruption. Deposition of these aerosols occur at the beginning
Mayewski, Paul A.   +5 more
core   +3 more sources

Pliocene and Pleistocene chronostratigraphy and paleoenvironment of the Central Arctic Ocean, using deep water agglutinated foraminifera [PDF]

open access: yes, 1998
Deep-water agglutinated foraminifera (DWAF) were studied from Cores PS2177-5, PS2200-5, PS2212-3 and PS2185-6; from the R/V POLARSTERN ARK-VIII/3 Cruise in the central Arctic Ocean.
Evans, J.R., Kaminski, M.A.
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

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