Results 81 to 90 of about 220,015 (302)
Changes in Imja Tsho in the Mount Everest Region of Nepal [PDF]
, 2014 Imja Tsho, located in the Sagarmatha ( Everest) National Park of Nepal, is one of the most studied and rapidly growing lakes in the Himalayan range. Compared with previous studies, the results of our sonar bathymetric survey conducted in September of ...
Byers, A. C. +3 more
core +2 more sources
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
Our Latest Glacial Period [PDF]
Nature, 1891 I AM informed that near the Wash, and I suppose at other parts of the coast, the sea at low water is frozen into masses which with the rising tide become floes, and are urged backwards and forwards on the beach. This is, I believe, not a frequent occurrence on our shores, and it would be interesting if any observers could note whether the shingle or ...
openaire +1 more source
Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity
FEBS Open Bio, EarlyView.Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz +9 more
wiley +1 more source
FEBS Open Bio, EarlyView.dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon +6 more
wiley +1 more source
Combination of geodetic observations and models for glacial isostatic adjustment fields in Fennoscandia [PDF]
, 2010 We demonstrate a new technique for using geodetic data to update a priori predictions for Glacial Isostatic Adjustment (GIA) in the Fennoscandia region.
Davis, James L. +3 more
core +2 more sources
Geochronological reconstruction of the glacial evolution in the Ésera valley (Central Pyrenees) during the Late Pleistocene and Holocene [PDF]
Climate of the PastSince the MIS (Marine Isotope Stage) 4, glaciers in the Pyrenees were subject to intricate dynamics, encompassing some advances and retreats not always aligned with the fluctuations observed in other European glaciers.
I. Vidaller +3 more
doaj +1 more source
FEBS Open Bio, EarlyView.A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li +6 more
wiley +1 more source
The northern sector of the last British ice sheet : maximum extent and demise [PDF]
, 2008 Strongly divided opinion has led to competing, apparently contradictory, views on the timing, extent, flow configuration and decay mechanism of the last British Ice Sheet.
Bradwell, Tom +11 more
core +2 more sources
Geochemical evidence for the origin of late Quaternary loess, Seward Peninsula, Alaska
Arctic, Antarctic, and Alpine ResearchLoess is the most widespread surficial deposit in the state of Alaska. Although loess of last glacial age is common in mid-continental North America, records of last glacial loess in Alaska have been elusive. Here we report a record of last glacial loess
Daniel R. Muhs, Jeffrey S. Pigati
doaj +1 more source