Results 51 to 60 of about 39,068 (264)

SmallTalk: a novel small‐sized fusion tag for peptide expression and purification

FEBS Open Bio, EarlyView.
The SmallTalk fusion tag allows for the efficient expression and purification of soluble recombinant proteins or peptides in Escherichia coli. Testing with SmallTalk‐GFP confirmed that the proteins were soluble and folded correctly, while SmallTalk‐Bin1b maintained its antimicrobial activity against various bacterial isolates. This streamlined workflow
Atika Tariq, Nestor G. Casillas‐Vega, Alma Gomez‐Loredo, Xristo Zarate   +3 more
wiley   +1 more source

Glacial Lakes in the Nepal Himalaya: Inventory and Decadal Dynamics (1977–2017)

Remote Sensing, 2018
Himalayan glaciers, in general, are shrinking and glacial lakes are evolving and growing rapidly in number and size as a result of climate change. This study presents the latest remote sensing-based inventory (2017) of glacial lakes (size ≥0.0036 ...
Nitesh Khadka, Guoqing Zhang, Sudeep Thakuri   +2 more
doaj   +1 more source

DDX3X induces mesenchymal transition of endothelial cells by disrupting BMPR2 signaling

FEBS Open Bio, EarlyView.
Elevated DDX3X expression led to downregulation of BMPR2, a key regulator of endothelial homeostasis and function. Our co‐immunoprecipitation assays further demonstrated a molecular interaction between DDX3X and BMPR2. Notably, DDX3X promoted lysosomal degradation of BMPR2, thereby impairing its downstream signaling and facilitating endothelial‐to ...
Yu Zhang, Jing Wang, De‐Hui Qian, Yang‐Fan Lv, Tian‐Le Cheng, Da‐Peng Wang, Jing Zhang, Ye Fan   +7 more
wiley   +1 more source

Geochemical evidence for the origin of late Quaternary loess, Seward Peninsula, Alaska

Arctic, Antarctic, and Alpine Research
Loess is the most widespread surficial deposit in the state of Alaska. Although loess of last glacial age is common in mid-continental North America, records of last glacial loess in Alaska have been elusive. Here we report a record of last glacial loess
Daniel R. Muhs, Jeffrey S. Pigati
doaj   +1 more source

ATP13A2 is involved in intracellular polyamine transport in lung epithelial cells

FEBS Open Bio, EarlyView.
Spermidine transport in lung epithelial cells involves the polyamine transporter ATP13A2. Cell proliferation is associated with the upregulation of ATP13A2. Polyamines are present in all living cells and are implicated in various crucial cellular processes such as proliferation, apoptosis and autophagy.
Yuta Hatori, Kohei Kawabata, Takanori Kubo, Takeo Kitazawa, Sae Kanai, Madoka Iwashita, Ami Hayashi, Hiroyuki Nishi, Mikihisa Takano   +8 more
wiley   +1 more source

Climate processes in the nival-glacial zone of Trans-Ili Alatau and their impact on mountain glaciation and runoff

Лëд и снег, 2015
On the basis of the latest monitoring data of a high-mountainous glaciological station of Institute of Geography, Republic of Kazakhstan on modern climate changes in the nival-glacial zone and their occurrences in the mode of river runoff are analyzed ...
E. N. Piven
doaj   +1 more source

Mudanças climáticas e impactos sócio-territoriais dos desastres glaciais na Cordilheira Branca, Peru

Confins, 2020
This article discusses the history of natural disasters in the Cordillera Blanca, Peru, during the 1970–2011 period. The study analyzed general disaster data over this timeframe and more broadly about glacial disasters from 1725 to 2010 AD. Historically,
Anderson Ribeiro de Figueiredo, Jefferson Cardia Simões, Álvaro Luiz Heidrich, Rualdo Menegat   +3 more
doaj   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Drying Meat Today as During the Late Glacial Period

EXARC Journal, 2013
Western Europe during the Upper Palaeolithic, between 42,000 years ago and 12,000 years ago, was sparsely wooded, but later there was an increase in the percentage of specimens of birch, abies, fagus and tilia hosting wildlife similar to that already ...
Edoardo Ratti and Valeria Cosma, Valeria Cosma   +1 more
doaj  

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

FEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li, Hiroko Ohmiya, Sou Sakamoto, Masato Yugami, Akiko Oki, Makoto Furusawa, Yan Ling   +6 more
wiley   +1 more source