Results 111 to 120 of about 28,257 (311)

H4K12 Lactylation Regulates NDUFS7 to Drive Microglia Reverse Electron Transport in Spinal Cord Injury

open access: yesAdvanced Science, EarlyView.
Lactate accumulation after SCI promotes H4K12la lactylation, which upregulates NDUFS7, triggering mitochondrial RET and ROS, enforcing pro‐inflammatory microglial polarization. MM@mPTC, a biomimetic nanotherapeutic, degrades LDHA in activated microglia, reducing H4K12la lactylation and blocking RET, thus curbing ROS, fostering a reparative phenotype ...
Chenglong Hong   +13 more
wiley   +1 more source

Eccentricity Paces Late Pleistocene Glaciations

open access: yesGeophysical Research Letters
Late Pleistocene glacial terminations are caused by rising atmospheric CO2 occurring in response to atmospheric and ocean circulation changes induced by increased discharge from Northern Hemisphere ice sheets.
T. Blackburn, S. Kodama, G. Piccione
doaj   +1 more source

Tri-dimensional Model of the Radovna Glacier from the Last Glacial Period

open access: yesGeologija, 2016
The Radovna River Valley is located in the northwest of Slovenia, in the Julian Alps, and bounded by two plateaus – Pokljuka in the south and Mežakla in the north.
Luka Serianz
doaj   +1 more source

The Fraser Glaciation in the Cascade Mountains, southwestern British Columbia

open access: yes, 2005
The objective of this study is to reconstruct the history of glaciation from the start of Fraser (Late Wisconsinan) Glaciation to the end of deglaciation, for three areas in the Cascade Mountains.
Waddington, Betsy Anne
core  

Diatom boron isotope data from ODP Site 882 over the intensification of Northern Hemisphere Glaciation

open access: yes
Diatom boron and boron isotope data from ODP Site 882 in the subarctic Pacific Ocean over the intensification of Northern Hemisphere glaciation (iNHG) at 2.73 ...
Rae, James W B   +3 more
core   +1 more source

SEC Mediates m6A Deposition and Transcription Pause Release to Drive Cell Identity Transition

open access: yesAdvanced Science, EarlyView.
The SEC promotes cell identity transitions by facilitating transcription pause release at key identity‐associated genes, including Klf4 and Myc during iPSC reprogramming and Nes and Tubb3 during ESC‐to‐neuroectodermal differentiation. During early iPSC reprogramming, this function additionally involves cooperation with METTL3‐associated m6A regulation.
Zhijing Zhang   +9 more
wiley   +1 more source

Geodynamic evolution of the Earth over the Phanerozoic: Plate tectonic activity and palaeoclimatic indicators

open access: yesJournal of Palaeogeography, 2015
During the last decades, numerous local reconstructions based on field geology were developed at the University of Lausanne (UNIL). Team members of the UNIL participated in the elaboration of a 600 Ma to present global plate tectonic model deeply rooted ...
Christian Vérard   +3 more
doaj   +1 more source

The Droseraceae during the glaciations

open access: yesCarnivorous Plant Newsletter, 1989
(Uploaded by Plazi from the Biodiversity Heritage Library) No abstract provided.
openaire   +1 more source

Duration and nature of the end-Cryogenian (Marinoan) glaciation [PDF]

open access: yes, 2016
The end-Cryogenian glaciation (Marinoan) is portrayed commonly as the archetype of snowball Earth, yet its duration and character remain uncertain.
Anthony R. Prave   +12 more
core   +1 more source

Engineering Spatially Localized Bioactive Microenvironments in Assembly Implants for Spatially Extended Bone Ingrowth

open access: yesAdvanced Science, EarlyView.
An assembly porous titanium/β‐TCP implant is developed to establish a spatially programmable osteogenic microenvironment for enhanced osseointegration. By decoupling mechanical support from bioactive ion release, localized ionic gradients generated from the β‐TCP module direct osteogenic activity and bone ingrowth toward the porous titanium framework ...
Heng Zhang   +5 more
wiley   +1 more source

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