Results 91 to 100 of about 28,309 (292)
Advanced Science, EarlyView.Ox‐mtDNA fragments escaping from mitochondria drive robust inflammatory responses. A targeted nanoplatform simultaneously inhibits mitochondrial FEN1‐mediated mtDNA cleavage and scavenges ROS, preventing the generation of immunogenic Ox‐mtDNA fragments. The released SeNPs further promote autophagic clearance of cytosolic mtDNA. Consequently, cGAS‐STING,
Wen‐Ling Li +7 more
wiley +1 more source
Carnets de Géologie, 2005 The Hirnantian is an important time in Earth history as it includes one of the major episodes of continental glaciation and marine mass extinction (e.g. Brenchley et alii, 1994).
Grassineau Nathalie +4 more
doaj
Advanced Science, EarlyView.Biomineralization underpins skeletal development, yet its molecular control remains incompletely understood. Using a novel murine knockout model, this study reveals the essential and complementary roles of PHOSPHO1 and TNAP in postnatal skeletal development.
Lucie E. Bourne +15 more
wiley +1 more source
Angewandte Chemie, EarlyView.Modular access to underexplored C5‐sulfenyl thiazoles via an intermolecular Pummerer rearrangement is reported. The methodology exhibits a broad functional group tolerance enabling the seamless design of trisubstituted thiazole cores bearing a sulfur handle for further elaboration.
Joe L. Smy +5 more
wiley +2 more sources
Present-day changes of mountain glaciers on the southern slope of the Dzhungarian Alatau range
Лëд и снег, 2015 Glacierization of southern slope of the Dzhungarian (Zhetysu) Alatau range was estimated by means of data obtained by operational satellite Landsat 7 surveys on August 19 and September 2011 (sensors ETM+) with the use of digital relief models (ASTER GDEM)
A. L. Kokarev, I. N. Shesterova
doaj +1 more source
TP53 Loss Elevates NF‐κB‐IFN‐β‐MHC‐Ia Signaling to Promote NK Cell Resistance in Osteosarcoma
Advanced Science, EarlyView.TP53 loss in a transforming or osteosarcoma cell promotes cytosolic DNA accumulation, activating NF‐κB‐dependent IFN‐β production. Autocrine IFN‐β signaling increases cell‐surface HLA‐Ia expression, strengthens inhibitory KIR signaling in natural killer cells, and thereby enables the affected cell to evade NK cell‐mediated cytotoxicity.
Guihui Qin +9 more
wiley +1 more source
Polar Research, 2014 We report on 10Be and optically stimulated luminescence ages from moraines and glaciolacustrine sediments on eastern Jameson Land, East Greenland. Sampled landforms and sediment are associated with advances of outlet glaciers from the local Liverpool ...
Helena Alexanderson, Lena Håkansson
doaj +1 more source
Glaciation of Siberia and the problem of massive ice beddings
Лëд и снег, 2017 As a result of many years of the author’s studies of glaciers and ground ices, a great amount of factual material has been collected for a purpose to analyze a possibility of burying the glaciers in the permafrost zone and to esti‑ mate a time of their ...
V. S. Sheinkman
doaj +1 more source
Advanced Science, EarlyView.A novel B2‐ordered Ti‐Zr‐V‐Al medium‐entropy intermetallic is developed through controlled metastability engineering, which activates an ordered TRIP effect via a new B2→D019‐α2 transformation with a distinctive {0001}α2//{110}B2, <11‐20>α2//<100>B2 orientation relationship. This alloy achieves an elongation of ∼7%, a strength of ∼1.1 GPa, and superior
Chaohua Li +8 more
wiley +1 more source