Results 71 to 80 of about 28,309 (292)
Advanced Science, EarlyView.During renal fibrosis, SMAD3 acts as a transcription factor for CRLF1, promoting its expression and secretion. CRLF1 then binds to ITGB1 via an autocrine mechanism, activating the PI3K‐AKT signaling pathway to mediate renal fibrosis. This accelerates the progression from AKI to CKD, highlighting the therapeutic potential of targeting CRLF1 for ...
Chunjie Wang +8 more
wiley +1 more source
Advanced Science, EarlyView.FES‐derived MGE spheroids exhibit progenitor‐stage alterations in developmental trajectory and hypoxia‐responsive transcriptional programs, followed by functional disruption. Gestational hypoxia recapitulates impaired progenitor proliferation, shortened cell‐cycle progression, interneuron developmental abnormalities, and schizophrenia‐like behaviors in
Peiyan Ni +17 more
wiley +1 more source
Working Hypotheses for Glaciation/Deglaciation Mechanisms
, 1992 Observations of a set of climatic and environmental parameters in ice cores indicate oscillations of the Earth system between a cold and a mild climatic state during the Wisconsin glaciation. The two states are determined by ocean circulation patterns: a
H. Oeschger, Oeschger, H.
core +1 more source
Groundwater Rise Sustains the World's Largest Alpine Water System Under Global Warming
Advanced Science, EarlyView.Shallow groundwater depth (SGWD) across the non‐permafrost plains of the Qinghai–Xizang Plateau decreased at averagely 0.02 m year−1, adding 31.44 Gt of freshwater storage from 2000 to 2020 and sustaining ∼53 500 km2 of alpine ecosystems. A vadose‐zone capacity of 426.6 Gt reveals these aquifers as promising reservoirs, highlighting groundwater's ...
Jianqing Du +15 more
wiley +1 more source
Advanced Science, EarlyView.A rare de novo IFT122‐A773E variant is identified in idiopathic pediatric uveitis and shown to exacerbate retinal inflammation and barrier dysfunction. Mechanistically, the variant enhances IFT43 interaction, elevates calcium signaling, and activates the MEK/ERK/FRA1 axis, revealing a previously unrecognized cilia‐associated pathway that may increase ...
Qian Zhou +18 more
wiley +1 more source
Grain Boundary Structure Ordering via Electroshock Treatment Enhances Strength‐Ductility Synergy
Advanced Science, EarlyView.Electroshock treatment triggers atomic rearrangement, transforming disordered grain boundaries into ordered states without inducing recrystallization. This grain boundary ordering effectively relieves strain concentration and strengthens boundaries, enabling a simultaneous improvement in both strength and ductility.
Jiancheng Chen +6 more
wiley +1 more source
THE GLACIATION OF NORTH CLEVELAND [PDF]
Proceedings of the Yorkshire Geological Society, 1908 Read 26th September, 1908. Manuscript received 5th December, 1908. Thanks to the great work of Professor Kendall in the Cleveland area, glacial geologists are now furnished with a key which will enable them to trace the history of the decline of the glaciers which debouched on to the plains of England during the Ice Age.
openaire +2 more sources
Air pollution sources leading to anthropogenic glaciation of supercooled liquid-water clouds
This dataset lists the air pollution sources leading to anthropogenic glaciation of supercooled liquid-water clouds.
Keernik, Hannes +2 more
core +1 more source
Covalently Linked Peptides and Membrane Potential Enable CyaA Segment Translocation
Advanced Science, EarlyView.Using a newly developed Droplet Interface Bilayer‐Pipette assay, the authors show that two segments of the CyaA toxin cross membranes by distinct mechanisms. One segment translocates spontaneously, whereas the translocation of the other depends on membrane potential.
Gaia Scilironi +9 more
wiley +1 more source