Results 101 to 110 of about 1,232,545 (297)

Recent glacier decline in the Kerguelen Islands (49°S, 69°E) derived from modeling, field observations, and satellite data [PDF]

, 2015
Date of Acceptance: 28/02/2015The retreat of glaciers in the Kerguelen Islands (49°S, 69°E) and their associated climatic causes have been analyzed using field data and Moderate Resolution Imaging Spectroradiometer (MODIS) satellite images to validate a ...
Gilbert, A., Jomelli, Vincent, Deborah Verfaillie, Vincent Jomelli, Hubert Gallée, Frenot, Y., Rinterknecht, Vincent, Dumont, Marie, Gallée, Hubert, Gallée, H., Rinterknecht, V., Menegoz, Martin, Frenot, Yves, Brunstein, D., Gilbert, Adrien, Gilbert, Vincent Favier, Verfaillie, D., Menegoz, M., Martin Menegoz, Dumont, M., Adrien Gilbert, Brunstein, Daniel, Jomelli, V., Daniel Brunstein, Favier, V., Favier, Vincent, Marie Dumont, Verfaillie, Deborah, Yves Frenot, Gilbert, Adrien,, Vincent Rinterknecht   +30 more
core   +1 more source

Mitochondria‐Targeted Multimodal Nanotherapeutics Suppress Oxidized mtDNA‐Driven Inflammation at the Source

Advanced Science, EarlyView.
Ox‐mtDNA fragments escaping from mitochondria drive robust inflammatory responses. A targeted nanoplatform simultaneously inhibits mitochondrial FEN1‐mediated mtDNA cleavage and scavenges ROS, preventing the generation of immunogenic Ox‐mtDNA fragments. The released SeNPs further promote autophagic clearance of cytosolic mtDNA. Consequently, cGAS‐STING,
Wen‐Ling Li, Juan Cao, Yu‐Lin Wang, Yu‐Han Fan, Jia‐Qi Xu, Xian Wu Cheng, Lei Xing, Hu‐Lin Jiang   +7 more
wiley   +1 more source

Global mapping of lake-terminating glaciers

Earth System Science Data
Abstract. Proglacial lakes at glacier termini have received widespread attention in the literature for their role in accelerating melt, velocity and contributing to cryospheric hazards. Although global and regional inventories for both glaciers and lakes exist, lake-terminating glaciers have not been consistently identified at the global scale.
Steiner, Jakob, Armstrong, William, Kochtitzky, Will, McNabb, Robert, Aguayo, Rodrigo, Bolch, Tobias, Maussion, Fabien, Agarwal, Vibhor, Barr, Iestyn, Baurley, Nathaniel R, Cloutier, Mike, DeWater, Katelyn, Donachie, Frank, Drocourt, Yoann, Garg, Siddhi, Joshi, Gunjan, Guzman, Byron, Kutuzov, Stanislav, Loriaux, Thomas, Mathias, Caleb, Menounos, Brian, Miles, Evan, Osika, Aleksandra, Potter, Kaleigh, Racoviteanu, Adina, Rick, Brianna, Sterner, Miles, Tallentire, Guy D, Tielidze, Levan, White, Rebecca, Wu, Kunpeng, Zheng, Whyjay   +31 more
openaire   +4 more sources

TNAP and PHOSPHO1 Function Synergistically to Afford Critical Control Over the Mineralization of the Postnatal Murine Skeleton

Advanced Science, EarlyView.
Biomineralization underpins skeletal development, yet its molecular control remains incompletely understood. Using a novel murine knockout model, this study reveals the essential and complementary roles of PHOSPHO1 and TNAP in postnatal skeletal development.
Lucie E. Bourne, Aikta Sharma, Scott Dillon, Jacob Keen, Soher N. Jayash, Natalie Crump, Lucinda A.E. Evans, Maya Karmali, Worachet Promruk, Claire E. Clarkin, Sonoko Narisawa, Louise Stephen, Brian L. Foster, José Luis Millán, Colin Farquharson, Katherine A. Staines   +15 more
wiley   +1 more source

TP53 Loss Elevates NF‐κB‐IFN‐β‐MHC‐Ia Signaling to Promote NK Cell Resistance in Osteosarcoma

Advanced Science, EarlyView.
TP53 loss in a transforming or osteosarcoma cell promotes cytosolic DNA accumulation, activating NF‐κB‐dependent IFN‐β production. Autocrine IFN‐β signaling increases cell‐surface HLA‐Ia expression, strengthens inhibitory KIR signaling in natural killer cells, and thereby enables the affected cell to evade NK cell‐mediated cytotoxicity.
Guihui Qin, Cheung Kwan Yeung, Ye Yi, Dejin Zheng, Miaoman Ye, Chi‐Chong Chio, Jinjie Wu, Siyi Fu, Chu‐Xia Deng, Ren‐He Xu   +9 more
wiley   +1 more source

A comparison of glacier melt on debris-covered glaciers in the northern and southern Caucasus [PDF]

, 2011
The glacier coverage in the Caucasus Mountains underwent considerable changes during the last decades. In some regions, the observed reduction in glacier area is comparable to those in the European Alps and the extent of supra-glacial debris increased on
W. Hagg, A. Lambrecht, Popovnin, V., Lambrecht, A., A. Rezepkin, Hagg, Wilfried, Svanadze, D., C. Mayer, Rezepkin, A., N. Lomidze, D. Svanadze, Lomidze, N., V. Popovnin, Mayer, C.   +13 more
core   +2 more sources

A New Ordered Transformation‐Induced Plasticity Enables Exceptional Strength and Ductility in a B2 Medium‐Entropy Alloy

Advanced Science, EarlyView.
A novel B2‐ordered Ti‐Zr‐V‐Al medium‐entropy intermetallic is developed through controlled metastability engineering, which activates an ordered TRIP effect via a new B2→D019‐α2 transformation with a distinctive {0001}α2//{110}B2, <11‐20>α2//<100>B2 orientation relationship. This alloy achieves an elongation of ∼7%, a strength of ∼1.1 GPa, and superior
Chaohua Li, Yidong Wu, Boyuan Zheng, Xu Zhang, Xiongjun Liu, Wenli Song, Ning An, Chengbo Xiao, Xidong Hui   +8 more
wiley   +1 more source

Magneto‐Sono‐Enhanced Nanozyme Catalysis Drives ROS‐Mediated Pathogen Killing and Mitophagy‐Linked Inflammation Control in Bacterial Pneumonia

Advanced Science, EarlyView.
Nebulized BN@NF nanozymes integrate boron nanosheets with Nd‐doped iron phosphide to form a sono‐magneto‐responsive Z‐scheme heterostructure. Under ultrasound and magnetic activation, BN@NF amplifies ROS generation, eradicates bacteria, disrupts biofilms, and reshapes pulmonary inflammation through NF‐κB suppression, mitophagy promotion, and M1‐to‐M2 ...
Xiaofeng Luo, Yundi Wu, Shuai Zhang, Huanran Qu, Shiyang Shao, Jianqiang Chen, Xilong Wu   +6 more
wiley   +1 more source

Response of a marine-terminating Greenland outlet glacier to abrupt cooling 8200 and 9300 years ago [PDF]

, 2011
Long-term records of Greenland outlet-glacier change extending beyond the satellite era can inform future predictions of Greenland Ice Sheet behavior. Of particular relevance is elucidating the Greenland Ice Sheet's response to decadal- and centennial ...
Greg S. Babonis, Nicolás E. Young, Babonis, G.S., Robert C. Finkel, Rood, D.H., Csatho, B., Beata Csatho, Young, N.E., Axford, Y., Briner, J.P., Dylan H. Rood, Jason P. Briner, Yarrow Axford, Finkel, R.C.   +13 more
core   +1 more source

ROS/pH‐Responsive Phenylboronic Acid–Chitosan Nanoparticles Improve Silymarin‐Mediated Hepatoprotection After Hepatectomy With Gut‐Liver Axis‐Associated Responses

Advanced Science, EarlyView.
Bioactive phenylboronic acid–chitosan nanoparticles enable responsive silymarin delivery for post‐hepatectomy liver protection. The nanoplatform integrates antioxidant and antibacterial functions, improves hepatic recovery, and is associated with coordinated shifts in gut microbiota, metabolites, cytokines, and hepatic proteomic pathways, suggesting a ...
Jinjin Tong, Chaochao Luo, Zezheng Liu, Xinyan Zhang, Daixu Jia, Yang Sun, Zhaonan Zhang, Haoran Shi, Jianfang Wang, Hua Zhang   +9 more
wiley   +1 more source