Results 111 to 120 of about 1,232,545 (297)

Developing Metal–Polyphenol Network‐Based Single‐Protein Particle Encapsulation System for Sustained Release of Whey Protein to Mitigate Sarcopenia

Advanced Science, EarlyView.
Sarcopenia has emerged as a major health challenge in the aging population. Developing a sustained‐release system for whey protein may enhance its effectiveness in mitigating sarcopenia. Herein, a novel “single‐protein particle encapsulation” (SPPE) system is developed to protect whey protein and control its release.
Yafei Zhang, Yuning Zhang, Yongjian Ai, Yao Lu, Heng Quan, Zhen Zhang, Yuqi Wang, Yujia Luo, Xiaoxu Zhang, Yingying Lin, Sijia Song, Huiyuan Guo   +11 more
wiley   +1 more source

H4K12 Lactylation Regulates NDUFS7 to Drive Microglia Reverse Electron Transport in Spinal Cord Injury

Advanced Science, EarlyView.
Lactate accumulation after SCI promotes H4K12la lactylation, which upregulates NDUFS7, triggering mitochondrial RET and ROS, enforcing pro‐inflammatory microglial polarization. MM@mPTC, a biomimetic nanotherapeutic, degrades LDHA in activated microglia, reducing H4K12la lactylation and blocking RET, thus curbing ROS, fostering a reparative phenotype ...
Chenglong Hong, Zhichen Jiang, Zhouwei Wu, Chenyu Wu, Jiang Liu, Kaijie Guo, Yihui Liang, Shaobo Xu, Yuchen Jin, Yong Xiao, Lei Guo, Hui Xu, Sunren Sheng, Chenggui Wang   +13 more
wiley   +1 more source

SEC Mediates m6A Deposition and Transcription Pause Release to Drive Cell Identity Transition

Advanced Science, EarlyView.
The SEC promotes cell identity transitions by facilitating transcription pause release at key identity‐associated genes, including Klf4 and Myc during iPSC reprogramming and Nes and Tubb3 during ESC‐to‐neuroectodermal differentiation. During early iPSC reprogramming, this function additionally involves cooperation with METTL3‐associated m6A regulation.
Zhijing Zhang, Jingyi Xu, Yonghong Wu, Yitong Qu, Xinglin Hu, Yuchen Sun, Yanshuang Wu, Zhonghua Liu, Jiaqiang Wang, Lei Lei   +9 more
wiley   +1 more source

Global glacier changes

, 2008
Changes in glaciers and ice caps provide some of the clearest evidence of climate change, and as such they constitute key variables for early detection strategies in global climate-related observations.
World Glacier Monitoring Service
core   +1 more source

Engineering Spatially Localized Bioactive Microenvironments in Assembly Implants for Spatially Extended Bone Ingrowth

Advanced Science, EarlyView.
An assembly porous titanium/β‐TCP implant is developed to establish a spatially programmable osteogenic microenvironment for enhanced osseointegration. By decoupling mechanical support from bioactive ion release, localized ionic gradients generated from the β‐TCP module direct osteogenic activity and bone ingrowth toward the porous titanium framework ...
Heng Zhang, Jingjing Diao, Junhua Ke, Naru Zhao, Yudi Kuang, Yingjun Wang   +5 more
wiley   +1 more source

Tracking extinct glaciers in GLIMS

Annals of Glaciology
Global Land Ice Measurements from Space (GLIMS), an initiative to build and distribute a database of global glacier data, has recently begun to track glaciers that have recently disappeared.
Bruce H. Raup, Liss Marie Andreassen, Dominic Boyer, Cymene Howe, Mauri Pelto, Antoine Rabatel   +5 more
doaj   +1 more source

LigHTS: Biomimetic Hydrogel Photo‐Fabrication for Imaging‐Based Ultra‐High‐Throughput Screening

Advanced Science, EarlyView.
LigHTS removes a key bottleneck for ultra‐high‐throughput screening (UHTS) by enabling biomimetic hydrogel microenvironments to be manufactured directly in standard multiwell plates. A single, collimated UV exposure with formulation‐tuned light penetration patterns an entire plate with UHTS‐grade uniformity (<20% CV), producing structured GelMA films ...
Alessandro Enrico, Sara Rigolli, Julius Zimmermann, Melissa Pezzotti, Eloisa Torchia, Moises Di Sante, Ferdinando Auricchio, Francesco S. Pasqualini   +7 more
wiley   +1 more source

Rock glaciers in the Hindu Kush Himalaya: A regional synthesis

Arctic, Antarctic, and Alpine Research
Rock glaciers are cryospheric landforms in high-mountain regions and indicators of permafrost occurrence and change under accelerating climate warming. This review synthesizes 67 peer-reviewed studies on rock glaciers across the Hindu Kush Himalaya (HKH)
Prashant Baral, Mohd. Farooq Azam, Sonam Wangchuk, Gh Jeelani, Suraj Mal, A. P. Dimri   +5 more
doaj   +1 more source

Toward Sustainable Separation and Recovery of Critical Metals From Discarded Industrial Perovskite Solar Modules

Advanced Science, EarlyView.
An architecture‐guided recycling process enables selective metal recovery from end‐of‐life perovskite solar modules by exploiting interfacial accessibility and calcination‐induced phase transformation. The process achieves >99.8% Pb removal, >99.7% In recovery, and >96.1% Cu recovery, while selectively retaining Sn in leaching residue.
Guang Hu, Zhaoyang Li, Shifa Zhou, Jie Qin, Sha Liang, Huabo Duan, Liang Huang, Jingping Hu, Huijie Hou, Hongjie Zhou, Ling Xu, Chao Chen, Jiang Tang, Jiakuan Yang   +13 more
wiley   +1 more source

Biotic Acceleration of Glacier Melting in Yala Glacier 9 Langtang Region, Nepal Himalaya

, 2020
In some Himalayan glaciers, the microbial production on the glacier surface is so large during the monsoon season that the surface of the ablation area is covered with a dark coloured mud-like material which mainly consists of algae and bacteria.
Hydrology, Glacier Snow
core