Results 121 to 130 of about 4,434 (254)

Expression, Purification, and Microscopy‐Based Assays for Engineered Recombinant Tyrosinated, Detyrosinated, and Δ2 Human Tubulin

Cytoskeleton, EarlyView.
ABSTRACT Microtubules are noncovalent polymers assembled from α/β tubulin dimers. Their structure, dynamics and interaction with effectors are regulated through the expression of diverse tubulin isotypes and chemically diverse posttranslational modifications, also known as the “tubulin code.” Understanding the biophysical correlates between tubulin ...
Jiayi Chen, Agnieska Szyk, Antonina Roll‐Mecak   +2 more
wiley   +1 more source

Talin1 Adhesion Morphology and Colocalization With Tensin3 Are Largely Unaffected by Polyacrylamide Substrate Stiffness

Cytoskeleton, EarlyView.
ABSTRACT Cells sense the stiffness of their extracellular matrix (ECM) and adapt their behavior accordingly. We investigated how ECM stiffness affects the spatial organization of talin1, a key mechanosensitive focal adhesion protein. Using polyacrylamide (PA) hydrogels with tunable stiffnesses (0.2–188 kPa), we analyzed cell morphology, migration ...
Joanna Hajduk, Patrycja Twardawa, Sylwia Bobis‐Wozowicz, Marta Szewczyk, Zenon Rajfur, Zbigniew Baster   +5 more
wiley   +1 more source

Scottish late-glacial moraines: debris supply, genesis and significance

, 2012
A variety of moraine forms were deposited by glaciers during the Loch Lomond Stadial. Study of such moraines and related landforms provides a valuable source of data on patterns of landscape evolution and climatic change. This thesis presents detailed
Benn, Douglas I.
core  

Detection of the GH Analogue Redalsomatropin Alfa in Sports Drug Testing: Immunological Approaches and LC‐HRMS/MS

Drug Testing and Analysis, EarlyView.
After evaluating the compatibility of the GH analogue redalsomatropin alfa with approved doping control immunoassays for rhGH, it was implemented into the existing detection method for somatrogon employing affinity purification with GHR‐Fc‐conjugated magnetic beads, tryptic digestion, and LC‐HRMS/MS to allow for a specific and sensitive detection ...
Katja Walpurgis, Andreas Thomas, Jasmin Thelen, Bettina Majer, Maneera Al‐Jaber, Wadha Abushareeda, Mario Thevis   +6 more
wiley   +1 more source

GAMDAM glacier inventory for High Mountain Asia

, 2018
First version of GAMDAM (Glacier Area Mapping for Discharge from the Asian Mountains) glacier inventory are the first glacier inventory covering the HMA (High Mountain Asia), and underestimated glacier area because they did not include steep slopes ...
Sakai, Akiko, Akiko Sakai (6966359)
core   +1 more source

Heterozygous Med13l mice recapitulate a developmental growth delay and craniofacial anomalies seen in MED13L syndrome

Developmental Dynamics, EarlyView.
Abstract Background Gene transcription is crucial for embryo and postnatal development and is regulated by the Mediator complex. Mediator is comprised of four submodules, including the kinase submodule (CKM). The CKM consists of MED13, MED12, CDK8, and CCNC.
Anna K. Leinheiser, Timothy T. Nguyen, Kayla M. Henry, Mariela Rosales, Eric Van Otterloo, Chad E. Grueter   +5 more
wiley   +1 more source

Glacial and periglacial geomorphology of the Drang Drung, Haskira, and Pensilungpa glaciers, Trans-Himalayan Ladakh, India

Journal of Maps
Glacial geomorphological mapping is vital for understanding the role of glaciers in shaping landscapes, as well as glacier response to climate change.
Shahid Younis Bhat, Emma-Louise Cooper, Levan G. Tielidze, Irfan Rashid, Andrew N. Mackintosh   +4 more
doaj   +1 more source

Age‐related trends in niche position and specialization in Neotropical vertebrates

Ecography, EarlyView.
Species' niche positions and breadths within a region's environmental space, measured through ecological niche factor analysis (ENFA) as marginality and specialization, can reflect evolutionary constraints related to lineage age. The ‘internal incumbency' hypothesis predicts that older species, due to competitive preemption, occupy more central niche ...
Carlos Calderón del Cid, Fabricio Villalobos, Ricardo Dobrovolski, Bruno Vilela   +3 more
wiley   +1 more source

Glacio-limnological interactions at lake-calving glaciers

, 2012
Iceberg calving is an efficient ablation process which introduces mechanical instability to glacier systems and can cause non-linear climatic response.
Haresign, Eleanor C.
core  

RaineyAbe/glacier-snow-cover-mapping: Second release

<p>Fixed AOI coverage filtering functions, added the "aoi_coverage" parameter as a user option.</p ...
Aberle, Rainey, Enderlin, Ellyn, Liu, Jukes   +2 more
core   +1 more source