Results 61 to 70 of about 3,398 (259)

A nanoplatform that induces dual‐amino acid deprivation to reverse tumor immunosuppression and enhance metabolic immunotherapy

BMEMat, EarlyView.
ZIF‐8‐based nanoparticles co‐delivering CB‐839 (glutaminase inhibitor) and 1‐MT (IDO1 inhibitor), dual‐targeting glutamine/tryptophan metabolism to induce immunogenic cell death, activate STING, block kynurenine production, reverse immunosuppression, and enhance cancer immunotherapy to suppress primary/distant tumors.
Wenli Ning, Yunhan Sun, Mingyang Li, Shilu Liu, Fangjie Yi, Hongfei Wang, Ruibing Bai, Dongdong Liu, Fen Zhao, Guiqiang Zhang, Xiao Fu   +10 more
wiley   +1 more source

Tailoring drug‐to‐lipid ratio in redox‐responsive lipid‐mimetic prodrug liposomes for superior cabazitaxel delivery and antitumor efficacy

BMEMat, EarlyView.
Redox‐responsive lipid‐mimetic prodrug liposomes with high drug‐to‐lipid ratios enhance cabazitaxel delivery, prolong circulation, and enable tumor‐selective drug release for superior antitumor efficacy and safety. Abstract Liposomes represent one of the most extensively investigated nanocarriers in drug delivery.
Shengyao Xu, Danping Wang, Si Zheng, Zhiyu Kuang, Ya Gao, Haiyu Zhao, Lurong Zhang, Jiayu Guo, Jingyi Zhang, Weiyao Li, Anhua Wang, Hongrui Lei, Zhonggui He, Ken‐ichiro Kamei, Jianzhao Niu, Lingyun Ma, Bingjun Sun   +16 more
wiley   +1 more source

A New Method for Automatic Glacier Extraction by Building Decision Trees Based on Pixel Statistics

Remote Sensing
Automatic glacier extraction from remote sensing images is the most important approach for large scale glacier monitoring. Commonly used band calculation indices to enhance glacier information are not effective in identifying shadowed glaciers and debris-
Xiao Liu, Hongyi Cheng, Jiang Liu, Xianbao Su, Yuchen Wang, Bin Qiao, Yipeng Wang, Nai’ang Wang   +7 more
doaj   +1 more source

Nacre‐inspired layered composite with excellent mechanical support and osteogenic potential for cervical interbody cage

BMEMat, EarlyView.
The cervical interbody cage needs to take both biomechanical and biological requirements into account. Here, a new‐style degradable, multicomponent, and bioinspired nacre‐like cervical interbody cage composite, which exhibits promising mechanical‐support‐related behavior and osteogenesis‐related potential, is designed and prepared.
Xiu‐Wu Guo, Shao‐Meng Wen, Tian‐Yu Xing, Yang Zhou, Chun‐Xin Wang, Chang Ge, Si‐Ming Chen, Wen‐Zhi Zhang, Shu‐Hong Yu   +8 more
wiley   +1 more source

Glacier speed-up as a possible precursor to volcanic eruptions at Mount Veniaminof, Alaska

Journal of Glaciology
Identifying early indicators of volcanic eruptions is a fundamental part of natural hazard management but is notoriously difficult. Here we consider whether monitoring changes in glacier velocity can help.
Michael Dieter Martin, Iestyn Barr, Benjamin Edwards, Matteo Spagnolo, Elias Symeonakis, Joseph Mallalieu, Kathryn Adamson, Donal Mullan, Maximillian Van Wyk de Vries   +8 more
doaj   +1 more source

Does Climate Risk Affect Employment Decisions? International Evidence

Business Strategy and the Environment, EarlyView.
ABSTRACT This study investigates the effect of climate risk on corporate employment decisions. Using a large sample from 41 countries, we find a positive association between climate risk and underinvestment in labor, notably manifesting as excessive employee layoffs.
Claude Francoeur, Faten Lakhal, Hamza Nizar, Zvi Singer   +3 more
wiley   +1 more source

Synthesis and Functional Properties of Fluorinated Phosphonate‐Substituted Porphyrins: Excellent Photosensitizers and Robust Precursors for Photoactive Langmuir–Schaefer Films

Chemistry – A European Journal, EarlyView.
This is a comprehensive study of new family of high functionalized meso‐tetraarylporphyrins. A synthetic approach to phosphonate‐substituted fluorinated porphyrins was developed. These compounds were investigated with respect to singlet oxygen generation and photostability.
Azhar Kechiche, Cyrille Monnereau, Chantal Andraud, Alla Bessmertnykh‐Lemeune, Yoann Rousselin, Andrey V. Cheprakov, Elizaveta V. Ermakova, Alexandra I. Zvyagina, Habib Nasri   +8 more
wiley   +1 more source

Utilising seismic station internal GPS for tracking surging glacier sliding velocity

Journal of Glaciology
Glacier ice flux is a key indicator of mass balance; therefore, accurate monitoring of ice dynamics is essential. Satellite-based methods are widely used for glacier velocity measurements but are limited by satellite revisit frequency.
Wojciech Gajek, Adrian Luckman, William D. Harcourt, Danni Mei Pearce, Richard Hann   +4 more
doaj   +1 more source

Surge of the Bivachny Glacier in 2012–2015

Лëд и снег, 2015
The surge of the Bivachny Glacier that occurred in 2012–2015 is analyzed with the use of photographing performed from International Space Station in 2001–2015 together with data of the satellite monitoring of 1972–2000.
V. M. Kotlyakov, L. V. Desinov, V. A. Rudakov   +2 more
doaj   +1 more source

Synthesis and characterization of amphiphilic nitroxide 1,1,3,3–tetraethylisoindoline–2–oxyl–5–sodium sulfonate (TEIOSNa)

The Canadian Journal of Chemical Engineering, EarlyView.
Abstract The synthesis and characterization of an amphiphilic nitroxide to be used as a controlling agent in a nitroxide‐mediated living radical polymerization in aqueous dispersion media is presented. In the first stage of nitroxide synthesis (phthalimide protection), two reaction methods were employed: traditional and microwave.
Enrique García‐Leal, Martha Eugenia Albores Velasco, René O. Vargas, Rubén Mil‐Martínez   +3 more
wiley   +1 more source