Results 81 to 90 of about 22,866 (307)
Advanced Science, EarlyView.An implantable hydrogel is designed to hold gene transfection agents engineered to turn early recurrent tumor cells into generators of synthetic EVs. These synthetic EVs can express engineered miR‐26a (E‐miR‐26a) for highly sensitive detection and PD‐1 (a PD‐L1‐blocking agent) for therapeutic intervention, thereby enabling early detection and ...
Junli Zhang +7 more
wiley +1 more source
Energy Absorption Comparison in GLARE-3 and GLARE-5 Composites
, 2022 International audienceToday, due to their much better properties than metals, composite materials are increasingly used in structural applications, especially in the aerospace and automotive industries. The innovations in composites have made it possible
Fahham, Hamidreza, Nikahd, Shahram
core +1 more source
Influence of external background optical radiation on the flat view angle of silicon photomultiplier
Весці Нацыянальнай акадэміі навук Беларусі: Серыя фізіка-тэхнічных навукThe article presents the results of a study of the influence of external background optical radiation on the flat angle of view of silicon photomultiplier tubes (SiPMs).
I. R. Gulakov +2 more
doaj +1 more source
Advanced Science, EarlyView.ARC3 levels are controlled by cytosolic and chloroplast proteolytic systems. PUB52 mediates ARC3 precursor ubiquitination and degradation in the cytosol, while CLPC1 promotes ARC3 degradation in chloroplasts, where ARC2 protects ARC3 from excessive breakdown. Disrupting these components causes chloroplast division defects, placing them upstream of ARC3.
Yang Yuan +5 more
wiley +1 more source
Glare recovery in age related maculopathy
, 1987 This study has investigated the dynamics of the glare recovery process in a group of subjects with age related maculopathy (ARM) and pre-aqe related maculopathy (PARM), and compared the results of these groups with a group of age-matched controls.
Collins, Michael J.
core
Advanced Science, EarlyView.Sepsis‐associated encephalopathy (SAE) lacks effective therapies. We developed ME@FDsi, a biomimetic nanodrug using a tetrahedral framework nucleic acid to deliver disulfiram and siTNFα. It crosses the blood‐brain barrier, targets M1 microglia, inhibits pyroptosis and inflammation, and scavenges ROS.
Huimin Shi +15 more
wiley +1 more source
Methods to Address Headlight Glare [PDF]
, 2009 The goal of this project was to design, implement, and validate a computerized Glare Meter Tool that could be used in the field to assess the level of glare from headlights of opposing vehicles in a variety of situations, without relying on subjective ...
Greenhouse, Daniel S. +3 more
core
Advanced Science, EarlyView.ABSTRACT Iron overload is a common metabolic disturbance in cancer and contributes to poor outcomes in renal cell carcinoma (RCC), yet its effects on the tumour immune microenvironment remain unclear. Here we identify a previously unrecognized immunosuppressive axis in which iron overload downregulates the palmitoyltransferase ZDHHC12 in CD8+ T cells ...
Xin Jin +16 more
wiley +1 more source
Advanced Science, EarlyView.Dysregulated TCA cycle contributes to Alzheimer's disease (AD) pathogenesis. Here, we show that microglial isocitrate dehydrogenase 1 (IDH1) is a critical driver. Elevated IDH1 disrupts citrate metabolism and mitochondrial function, exacerbating AD pathology.
Qianqian Li +13 more
wiley +1 more source
Population-based case–control study of the effect of sun glare on pedestrian fatalities in Taiwan
BMJ Open, 2019 Objectives Sun glare is a serious driving hazard and increases crash risks. Relatively few studies have examined the effects of sun glare on pedestrian fatalities, given that a crash has occurred.
Hon-Ping Ma +5 more
doaj +1 more source