Results 71 to 80 of about 18,941 (313)

UDP‐Glucose‐6‐Dehydrogenase Mediated O‐GlcNAcylation of Tight Junction Protein 1 Suppresses Metastasis in Renal Cell Carcinoma

Advanced Science, EarlyView.
Our research unveiled a regulatory paradigm wherein TRIM25 orchestrates the ubiquitin‐mediated degradation of UGDH. UGDH modulates the protein stability of TJP1 by regulating O‐GlcNAcylation levels, effectively impeding the metastasis of ccRCC. Our insights elevate UGDH to a pivotal biomarker and tumor suppressor, marking the first demonstration that ...
Xiaolin Chen, Yuhang Bao, Tao Liu, Jianhui Qiu, Yuanyuan Ma, Zedan Zhang, Chuandong Wang, Ruiyi Deng, Zheng Song, Tianyi He, Haode Liu, Jingcheng Zhou, Yizhou Wang, Kan Gong   +13 more
wiley   +1 more source

Microglial Deubiquitinase OTUD7B Stabilizes STAT3 to Promote Neuroinflammation and Cognitive Decline in Alzheimer's Disease

Advanced Science, EarlyView.
. ABSTRACT Neuroinflammation driven by microglial activation is a defining feature of Alzheimer's disease (AD), yet the molecular mechanisms sustaining this proinflammatory state remain unclear. Here, we identify the deubiquitinase OTUD7B as a critical regulator of microglial activation and AD pathology.
Luyao Li, Hao Tang, Qin Yu, Yuyang Zhang, Binglu Shi, Ying Kong, Leiyu Xu, Jingjing Shao, Chenghong Hu, Lingyu She, Zhe Wang, Haiyi Chen, Aleksandr V. Samorodov, Gang Cao, Xia Zhao, Yi Wang   +15 more
wiley   +1 more source

Optimisation of Passive Solar Design Strategies in Side-lit Offices: Maximising Daylight Penetration While Reducing the Risk of Glare in Different Chilean Climate Contexts [PDF]

, 2020
Cecilia Palarino-Vico, María Beatriz Piderit   +1 more
openalex   +1 more source

Astrocytic Phenotypic Switching in Posterior Piriform Cortex Orchestrates Bone Cancer Pain–Depression Comorbidity via Purinergic–Noradrenergic Signaling

Advanced Science, EarlyView.
Bone cancer pain and depression share a common origin: astrocytic A2‐to‐A1 transition in the posterior piriform cortex. This phenotypic shift disrupts the ATP–adenosine–A2AR–norepinephrine axis, simultaneously driving nociceptive and affective dysfunction.
Jiang‐Ping Liu, Jun‐Han Zhang, Zhi‐Xuan Tan, Wei‐Bing Yan, Ya‐Ru Yuan, Yao Liu, Bing‐Di Wei, Meng‐Qi Ding, Zhuo‐Min Fu, Ying Liu, An‐Qi Wang, Lin Ma, Yong‐Hong Li, Er‐Qing Chai, Chao‐Jun Wei   +14 more
wiley   +1 more source

Population-based case–control study of the effect of sun glare on pedestrian fatalities in Taiwan

BMJ Open, 2019
Objectives Sun glare is a serious driving hazard and increases crash risks. Relatively few studies have examined the effects of sun glare on pedestrian fatalities, given that a crash has occurred.
Hon-Ping Ma, Ping-Ling Chen, Shang-Ku Chen, Liang-Hao Chen, Vaclav Linkov, Chih-Wei Pai   +5 more
doaj   +1 more source

Noise, Glare, and Dirt [PDF]

, 1992
William C. Beck
openalex   +1 more source

The Relationship between Solid Angle, Eccentric Angle, and Luminance of Glare Source Under the BCD Condition to Understand the Effect of Visual Characteristics on Discomfort Glare

, 2021
Kazuto Takase, Naoya Hara
openalex   +2 more sources

Fatigue Life Estimation with Mean Stress Effect Compensation for Lightweight Structures—The Case of GLARE 2 Composite [PDF]

, 2020
Michał Böhm, Karolina Głowacka
openalex   +1 more source

Sustainable Fabrication of Tailored Bone Substitutes: From High‐Throughput Scaffold Manufacturing, Scaled‐Up HMSC Expansion to Dynamic Cultivation in a Perfusion Bioreactor

Advanced Science, EarlyView.
ABSTRACT The demand for off‐the‐shelf biocompatible bone substitutes has driven the development of numerous independent in vitro technologies to generate products resembling physiological tissues. Due to technical challenges and overly simplified cultivation approaches/niches, the end‐products are often uniformly shaped and inferior to native bone ...
Franziska Braun, Anna Paříková, Sandra Rother, Martin Kantor, Salman Muhammad Ilyas, Ricardo Bernhardt, Pavel Ndjawa Yomi, Jaromír Havlica, Revathi Appali, Benjamin Kruppke, Poh Soo Lee   +10 more
wiley   +1 more source

An Enhanced NSGA-II Algorithm with Parameter Categorization for Computational-Efficient Multi-Objective Optimization of Active Glass Curtain Wall Shading Systems

Energies
To address the limitations of the Non-Dominated Sorting Genetic Algorithm (NSGA-II) in optimizing active glass curtain wall shading systems—particularly its suboptimal convergence efficiency and high computational demands—this study proposes an improved ...
Dezhao Tang, Zhiyong Wang
doaj   +1 more source