Results 71 to 80 of about 2,990,046 (310)
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
EPJ Web of Conferences, 2017 In this paper we introduce and apply the method for determination of the glass transition temperature of the sub-100 nm thick freestanding and supported polymer films based on thermally assisted atomic force microscopy (AFM). In proposed approach changes
Chernykh Elena +4 more
doaj +1 more source
Journal of Materials Research and Technology, 2016 The present work reports the results of non-isothermal DSC measurements on some Se-based ternary glasses for evaluation of activation of glass transition.
Shipra Saraswat +2 more
doaj +1 more source
Double glass transition in polyethylene naphthalate by MDSC, BDS, and TSDC [PDF]
In this work, we present an experimental study of the primary and secondary relaxations of the semi-crystalline polymer polyethylene naphthalate by modulated differential scanning calorimetry, Thermally Stimulated Depolarization Currents (TSDCs), and ...
Diego Vives, José Antonio +6 more
core +1 more source
Editorial Challenging Glass Conference 8
, 2022 We gradually emerge from two difficult years of the covid-19 pandemic raging through the world in waves of constantly changing intensities. The associated uncertainties really put the ‘challenging’ into Challenging Glass this time.
Bos, Freek (author) +2 more
core +1 more source
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
Dynamics and thermodynamics of the glass transition [PDF]
Physical Review E, 2006 The principal theme of this paper is that anomalously slow, super-Arrhenius relaxations in glassy materials may be activated processes involving chains of molecular displacements. As pointed out in a preceding paper with A. Lemaitre, the entropy of critically long excitation chains can enable them to grow without bound, thus activating stable thermal ...
openaire +3 more sources
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
Nanomechanical thermal analysis of the glass transition of polymers using silicon cantilevers
, 2012 1
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