Results 51 to 60 of about 2,990,046 (310)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Kinetics of Glass Transition and Crystallization in Carbon Nanotube Reinforced Mg-Cu-Gd Bulk Metallic Glass

, 2006
Mg65 Cu25 Gdlo bulk metallic glass and its carbon nanotube reinforced composite were prepared. Differential scanning calorimeter (DSC) was used to investigate the kinetics of glass transition and crystallization processes.
王育人, 孙玉峰, 李维火, 魏炳忱, Wang, YR (reprint author), Chinese Acad Sci, Inst Mech, Beijing 100080, Peoples R China., 王银春   +5 more
core   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Stress Dependency of Creep Response for Glass/Epoxy Composite at Nonlinear and Linear Viscoelastic Behavior

International Journal of Polymer Science, 2022
This research is aimed at comparing the stress dependency of creep viscoelastic behavior for glass/epoxy composite and neat epoxy close to the glass transition temperature and room temperature.
N. Nosrati, A. Zabett, S. Sahebian
doaj   +1 more source

Simulation procedures for glass transition temperatures and thermal expansion coefficients of BaO-B2O3 glasses

, 2016
In order to reflect the so-called boron anomaly, three types of B-O structural units, namely, BO3/2, BO4/2- and BO2/2O-, were considered for the BaO-B2O3 glass.
Zhu, QS, Zhu, Qingshan, Xie, Zhaohui, Peng, Lian   +3 more
core   +1 more source

Joint Research Project (in progress): Draft Standard for Determining the Thermal Stress of Glass and Glass-Glass PV Modules (BIPV) in the Construction Industry

, 2022
For the design of façade and roof glazing, loads due to dead weight, climatic loads (IGU - pressure differences), wind and snow are well investigated and are considered in engineering practice.
Schwind, Gregor, Erban, Christof, Ensslen, Frank, Beinert, Andreas, Michael, Elstner, Schneider, Jens, Röhner, Joachim, Mahfoudi, Achor, Schäfer, Steffen, Polakova, Michaela, Herzberg, Wiebke, Lorenz, Elke, Sommer, Robert, Mahfoudi, Achour   +13 more
core   +1 more source

Polymer Relaxation Time Enhancement at Temperatures above Glass Transition Temperatures Predicted by Idealized Mode-Coupling Theory [PDF]

, 2022
The mode-coupling theory of glass transition predicts the relaxation time divergence of glass-forming materials at the crossover temperature, which is approximately 1.2 times the calorimetric glass transition temperature. However, this divergence has not
Risa, Fukase, Mitsuru, Ishikawa, Keita, Matsumoto, Tomoya, Yamazaki, Yutaka, Ichikawa, Takayuki, Uwada   +5 more
core   +2 more sources

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Accessing ultrastable glass via a bulk transformation

Nature Communications
As a medium to understand the nature of glass transition, ultrastable glasses have garnered increasing attention for their significance in fundamental science and technological applications.
Hengtong Bu, Hengwei Luan, Jingyi Kang, Jili Jia, Wenhui Guo, Yunshuai Su, Huaping Ding, Hsiang-Shun Chang, Ranbin Wang, You Wu, Lingxiang Shi, Pan Gong, Qiaoshi Zeng, Yang Shao, Kefu Yao   +14 more
doaj   +1 more source