Results 91 to 100 of about 228,673 (302)
Molecular Oncology, EarlyView.Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani +9 more
wiley +1 more source
Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source
Structural studies of metal doped phosphate glasses and computational developments in diffraction analysis [PDF]
, 2009 The thesis focuses on the analysis and determination of the structure of various metal doped phosphate glasses, which are of interest for their potential biomedical properties.
Moss, Rob M.
core
, 2010 Efficient thermal poling of electronically conducting glass is prevented by the inherent difficulty to record a large electrostatic field within such glasses.
Kazansky, P.G. +14 more
core +1 more source
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source
The Journal of the Society of Chemical Industry, Japan, 1958 今日,pHの測定には,ほとんどガラス電極が使用されている現状であり,また,このガラス電極の進歩によって,更に,pH自動制御の可能性が生まれてきた。本研究ではガラス電極用ガラスの性能改良化を目的として,リチウム・ガラス(Li2O含量を26～28mol%に固定)の組成を系統的に変化させ,各ガラス成分のガラス電極特性に及ぼす影響を検討してみた。その結果,ZrO2,CeO2,Al2O3,V2O5,B2O3等の成分で,BaOを置換していくと,いずれもアルカリ誤差の大きくなることがわかった。また,アルカリ誤差の小さいガラスの組成は,SiO259～64mo1%,Li2O26～28mol%,La2O3+ BaO10～13mo1%であった。
Shinzo Okada +2 more
openaire +2 more sources
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy
Molecular Oncology, EarlyView.We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley +1 more source
Quantum-Chemistry Study of the Hydrolysis Reaction Profile in Borate Networks: A Benchmark
MoleculesThis investigation involved an ab initio and Density Functional Theory (DFT) analysis of the hydrolysis mechanism and energetics in a borate network. The focus was on understanding how water molecules interact with and disrupt the borate network, an area
Francesco Muniz-Miranda +4 more
doaj +1 more source
FEBS Open Bio, EarlyView.RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz +6 more
wiley +1 more source