Results 121 to 130 of about 21,105,669 (168)

Glutathione‑degrading enzymes in the complex landscape of tumors (Review). [PDF]

Int J Oncol
Zhang T, Yao C, Zhou X, Liu S, Qi L, Zhu S, Zhao C, Hu D, Shen W.   +8 more
europepmc   +1 more source

Cardioprotective strategies in myocardial ischemia-reperfusion injury: Implications for improving clinical translation. [PDF]

J Mol Cell Cardiol Plus
Tong C, Zhou B.
europepmc   +1 more source

Autophagy in oral cancer: Promises and challenges (Review). [PDF]

Int J Mol Med
Li Z, Zhang Y, Lei J, Wu Y.
europepmc   +1 more source

Total Synthesis of (-)-Glaucocalyxin A. [PDF]

Angewandte Chemie, 2020
A practically useful method for the formation of the highly oxygenated bicyclo[3.2.1]octane ring system by Mn(OAc) 3 -mediated radical cyclization of alkynyl ketones has been developed, which opens up a new avenue to the total synthesis of a number of ...
Yanxing Jia, Jiuzhou Guo, Bo Li, Wei-yong Ma, Mallesham Pitchakuntla   +4 more
semanticscholar   +4 more sources

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Chemoproteomics Reveals Glaucocalyxin A Induces Mitochondria‐Dependent Apoptosis of Leukemia Cells via Covalently Binding to VDAC1

Advanced Biology, 2023
Chronic myelogenous leukemia (CML) that is resistant to tyrosine kinase inhibitors is one of the deadliest hematologic malignancies, and the T315I mutation in the breakpoint cluster region‐Abelson (BCR‐ABL) kinase domain is the most prominent point ...
Yehai An, Qian Zhang, Yu Chen, Fei Xia, Y. Wong, Hengkai He, Mingjing Hao, Jiahang Tian, Xiaoyong Zhang, Piao Luo, Jigang Wang   +10 more
semanticscholar   +3 more sources

Glaucocalyxin A attenuates carbon tetrachloride‐induced liver fibrosis and improves the associated gut microbiota imbalance

Chemical Biology & Drug Design, 2023
Liver fibrosis refers to the pathophysiological process of dysplasia on the connective tissue of the liver, caused by a variety of pathogenic factors. Glaucocalyxin A (GLA) has anticoagulation, antibacterial, anti‐inflammation, antioxidant and antitumour
Ru Qu, Wang Zhang, Zhuang Ma, Qianwen Ma, Mingju Chen, Tian Lan, Lin Zhou, Xu-guang Hu   +7 more
semanticscholar   +3 more sources

New 3-acyl derivatives of glaucocalyxin A: designed, synthesis and in vitro antibacterial activities

Journal of Asian Natural Products Research
To discover novel antimicrobial drug, 22 novel acylated derivatives were synthesized by A-ring modification of glaucocalyxin A. The structures of these derivatives were confirmed by NMR and MS data.
Wei Yang, Wei-Qing Zhang, Mei-Qi Wei, Mei-Hui Duan, Xian-Ji Liu, Chen Yan   +5 more
semanticscholar   +3 more sources

Synthesis and in vitro anticancer activities of biotinylated derivatives of glaucocalyxin A and oridonin

Journal of Asian Natural Products Research, 2020
Fourteen glaucocalyxin A biotinylated derivatives, one glaucocalyxin C biotinylated derivative, and two oridonin biotinylated derivatives were designed and synthesized. Their structures were confirmed from 1H NMR, 13C NMR and HRMS data.
Xiaolei Huang, Jing-Lei Chen, Xian-Lun Li, Lei Zhao, Yadong Cui, Jiang-yun Liu, S. Morris-Natschke, Goto Masuo, Yung-Yi Cheng, K. Lee, Dao-feng Chen, Jian Zhang   +11 more
semanticscholar   +3 more sources

Synthesis and Cytotoxicity Assessment of Novel 7-O- and 14-O-Derivatives of Glaucocalyxin A.

Anti-Cancer Agents in Medicinal Chemistry, 2020
BACKGROUND Rabdosia japonica has been historically used in China as a popular folk medicine for the treatment of cancer, hepatitis, and gastricism. Glaucocalyxin A (GLA), an ent-kaurene diterpene isolated from Rabdosia japonica, is one of the main active
Hong-chuan Liu, Li-Ming Qiao, Wei Zheng, Z. Xiang, H. Chen, Shi-chong Yu, Dazhi Zhang, Ting Wang, Yue Zhang, Yong-Sheng Jin   +9 more
semanticscholar   +3 more sources

Glaucocalyxin A inhibits hydrogen peroxide‐induced oxidative stress and inflammatory response in coronary artery smooth muscle cells

Clinical and Experimental Pharmacology and Physiology, 2020
Atherosclerosis is a complex chronic inflammatory disease that remains one of the leading causes of death and disability worldwide. A previous study reported that glaucocalyxin A (GLA), a natural ent‐Kaurane diterpenoid triptolide, exhibits anti ...
Shunming Zhu, Junbo Zhang, Ying Lv
semanticscholar   +3 more sources