Results 131 to 140 of about 21,105,669 (168)

Glaucocalyxin A induces apoptosis and autophagy in tongue squamous cell carcinoma cells by regulating ROS

Cancer Chemotherapy and Pharmacology, 2021
Tongue squamous cell carcinoma (TSCC) is the most common highly invasive oral cancer. Glaucocalyxin A (GLA) is a diterpenoid component isolated from Rabdosia japonica var. with anti-bacterial and anti-cancer biological properties. However, the role of GLA in human TSCC remains uncertain.
Fanzhe Shi, Danfeng Xue, Q. Jiang, J. Qiu   +3 more
semanticscholar   +3 more sources

Interaction of glaucocalyxin a with glutathione and thioredoxin reductase for triple-negative breast cancer treatment.

Bioorganic Chemistry
Glaucocalyxin A (GLA) is a bioactive diterpenoid isolated from Rabdosia japonica var. that has been applied for centuries in traditional Chinese medicine. Although GLA exhibits potent anticancer activity against various human cancer cells, its cellular targets remain largely unidentified.
Dongzhu Duan, Xing Yang, Xiangyu Guo, Mi Li, Xiaojie Jin, Le Wang, Jian Xiao, Xiaoling Wang, Peng Song   +8 more
semanticscholar   +3 more sources

Glaucocalyxin A impairs tumor growth via amplification of the ATF4/CHOP/CHAC1 cascade in human oral squamous cell carcinoma.

Journal of Ethnopharmacology, 2022
ETHNOPHARMACOLOGICAL RELEVANCE The natural extract glaucocalyxin A (GLA), purified from the aboveground sections of the Chinese traditional medicinal herb Rabdosia japonica (Burm. f.) Hara var.
Xin Wang, Ming He, Xiao-Jie Chen, Yuding Bai, Gang Zhou   +4 more
semanticscholar   +1 more source

Glycosylation of Glaucocalyxin a and Evaluation of Its Cytotoxic Activity

Chemistry of Natural Compounds, 2020
The 7,14-diglucoside of glaucocalyxin A was prepared by a five-step reaction. Its structure was confirmed by spectroscopic methods, and its cytotoxic activity was tested by the MTT method.
Zhaobao Xiang, Yan Zhang, Yongsheng Jin, Bin Sun, Gang Chen   +4 more
semanticscholar   +2 more sources

Glaucocalyxin A induces apoptosis of non–small cell lung carcinoma cells by inhibiting the PI3K/Akt/GSK3β pathway

Clinical and Experimental Pharmacology and Physiology, 2022
Lung cancer is one of the fastest growing malignancies in morbidity and mortality, and current therapies are in general not sufficiently effective for this deadly disease.
De Zhang, Ting Deng, Wa Yuan, Tongqian Chen, Shuping Jiang   +4 more
semanticscholar   +1 more source

Glaucocalyxin A: a review

Natural Product Research, 2014
Glaucocalyxin A is a natural ent-Kaurane diterpenoid. It has been widely studied for some important biological activities like cytotoxicity and anti-tumour, anti-bacterial, anti-oxidative, anti-coagulative, anti-thrombotic, immune and anti-neuroinflammatory activities.
Zhaobao, Xiang, Xiaoling, Wu, Xingyu, Liu, Yongsheng, Jin   +3 more
openaire   +2 more sources

Transcriptomic and Metabolomic Analysis of Isodon suzhouensis Reveals a Potentially IsCPS1 Gene for Glaucocalyxin A Biosynthesis

Russian Journal of Plant Physiology
F. Liu
semanticscholar   +2 more sources

Glaucocalyxin A alleviates LPS-mediated septic shock and inflammation via inhibiting NLRP3 inflammasome activation.

International Immunopharmacology, 2020
Glaucocalyxin A (GLA) is a bioactive ent-kauranoid diterpenoid derived from the herbal medicine, Rabdosia japonica var. glaucocalyx, and it has been reported to possess marked anti-inflammatory properties. However, the underlying mechanisms are not fully understood.
Xiaorong Hou, Guang Xu, Zhilei Wang, Xiaoyan Zhan, Hui-fang Li, Rui-sheng Li, Wei Shi, Chunyu Wang, Yuanyuan Chen, Yongqiang Ai, Xiaohe Xiao, Zhaofang Bai   +11 more
semanticscholar   +3 more sources

Synthesis and Cytotoxic Activity of Hydroxy-Substituted Glaucocalyxin A

Pharmaceutical Chemistry Journal, 2019
Six new glaucocalyxin A derivatives were synthesized by hydroxy substitution, their structures were elucidated on the basis of spectral analysis, and cytotoxic activity was tested by MTT method. Not all of the obtained glaucocalyxin A derivatives have their cytotoxicity enhanced as a result of this substitution.
Zhaobao Xiang, Xiaoling Wu, Xuxu Zheng
openaire   +1 more source

Glaucocalyxin A improves survival in bleomycin-induced pulmonary fibrosis in mice

Biochemical and Biophysical Research Communications, 2017
Idiopathic pulmonary fibrosis (IPF) is a progressive interstitial lung disease with unclear etiology and poor prognosis. Despite numerous studies on the pathogenesis of IPF, only scant treatment options are available for the management of IPF. Glaucocalyxin A (GLA), an ent-Kaurane diterpenoid, has been demonstrated to exert anti-inflammatory, anti ...
Fei, Yang, Yiren, Cao, Jian, Zhang, Tao, You, Li, Zhu   +4 more
openaire   +2 more sources