Computational and Mathematical Methods in Medicine, Volume 2022, Issue 1, 2022., 2022 The severe acute respiratory syndrome coronavirus type 2 (SARS‐CoV‐2), also referred to as COVID‐19, has spread to several countries and caused a serious threat to human health worldwide. Patients with confirmed COVID‐19 infection spread the disease rapidly throughout the region.
Chengcheng Li +4 more
wiley +1 more source
Oxidative Medicine and Cellular Longevity, Volume 2022, Issue 1, 2022., 2022 Osteosarcoma (OS) is the most common malignancy of bone. Liensinine exerts antitumor effects on cancers of the colon, breast, and gallbladder. However, its antitumor activity in OS remains unclear. This study is aimed at investigating the efficacy of liensinine against OS and the underlying mechanism of action.
Fei Jia +6 more
wiley +1 more source
STAT3 and its targeting inhibitors in osteosarcoma
Cell Proliferation, Volume 54, Issue 2, February 2021., 2021 Signal transducer and activator of transcription 3 (STAT3) is a member of the STAT protein family, vitally important for eukaryotic cells. We review the molecular structure and function of STAT3 and its isoforms, highlighting signalling pathways for the regulation of gene transcription. A critical appraisal of STAT3 in cancers, such as osteosarcoma, is
Yun Liu +7 more
wiley +1 more source
Histamine induced high mobility group box-1 release from vascular endothelial cells through H-1 receptor [PDF]
, 2022 BackgroundSystemic allergic reaction is characterized by vasodilation and vascular leakage, which causes a rapid, precipitous and sustained decrease in arterial blood pressure with a concomitant decrease of cardiac output.
Gao, Shangze +7 more
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nutraceuticals an integrative approach to starve parkinson s disease [PDF]
, 2020 The therapeutic approach of multifactorial complex diseases is always a challenge; Parkinson's disease (PD) is a heterogeneous neurodegenerative disorder triggered by genetic and environmental factors, contributing to its etiology.
Adriano Lama +7 more
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Development of novel herbal compound formulations targeting neuroinflammation : network pharmacology, molecular docking, and experimental verification [PDF]
, 2023 Neuroinfammation plays an important role in the onset and progression of neurodegenerative diseases. Te multicomponent and multitarget approach may provide a practical strategy to address the complex pathological mechanisms of neuroinfammation. Tis study
Chang, Dennis Hsu-Tung (R7407) +2 more
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Regulation of microglia activity by glaucocalyxin-A: attenuation of lipopolysaccharide-stimulated neuroinflammation through NF-κB and p38 MAPK signaling pathways. [PDF]
PLoS ONE, 2013 Microglial cells are the resident macrophages and intrinsic arm of the central nervous system innate immune defense. Microglial cells become activated in response to injury, infection, environmental toxins, and other stimuli that threaten neuronal ...
Byung-Wook Kim +7 more
doaj +1 more source
Inhibition Peroxiredoxin-2 by Capsaicin Ameliorates Rheumatoid Arthritis via ROS-Mediated Apoptosis in Fibroblast-Like Synoviocytes. [PDF]
MedComm (2020)Capsaicin attenuating arthritis by inhibiting AKT phosphorylation and activating the NRF2–HO‐1 axis via targeting PRDX2 ABSTRACT Rheumatoid arthritis (RA), a prevalent and incurable autoimmune disease globally, is characterized by the immune system attacking the body's own tissues, leading to joint inflammation and damage.
He H +9 more
europepmc +2 more sources
Phytochemical Omics in Medicinal Plants [PDF]
, 2022 Medicinal plants are used to treat diseases and provide health benefits, and their applications are increasing around the world. A huge array of phytochemicals have been identified from medicinal plants, belonging to carotenoids, flavonoids, lignans, and
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Identification of Anti-Neuroinflammatory Bioactive Compounds in Essential Oils and Aqueous Distillation Residues Obtained from Commercial Varieties of Cannabis sativa L [PDF]
, 2023 Neuroinflammation, which is mainly triggered by microglia, is a key contributor to multiple neurodegenerative diseases. Natural products, and in particular Cannabis sativa L., due to its richness in phytochemical components, represent ideal candidates to
Angeloni, Cristina +10 more
core +2 more sources