Results 21 to 30 of about 114,625,331 (143)

Melatonin Promotes BMSCs Osteoblastic Differentiation and Relieves Inflammation by Suppressing the NF‐κB Pathways

Stem Cells International, Volume 2023, Issue 1, 2023., 2023
Bone mesenchymal stem cells (BMSCs) play an important role in maintaining the dynamic balance of bone metabolism. Recent studies have reported that a decrease in the osteogenic function of MSCs is strongly associated with osteoporosis. Melatonin is a neuroendocrine hormone produced in the pineal gland and is essential in the physiological regulation ...
Yiqiang Hu, Yuan Xiong, Kangkang Zha, Rangyang Tao, Lang Chen, Hang Xue, Chenchen Yan, Ze Lin, Yori Endo, Faqi Cao, Wu Zhou, Guohui Liu, Zhaoji Pan   +12 more
wiley   +1 more source

Glaucocalyxin A exerts anticancer effect on osteosarcoma by inhibiting GLI1 nuclear translocation via regulating PI3K/Akt pathway. [PDF]

Cell Death Dis, 2018
Osteosarcoma, the most common malignant bone tumor with recurring disease or lung metastases, has become one of the leading causes of death in humans. In the current study, we made an investigation on the anticancer effect of glaucocalyxin A, a bioactive
Zhu J, Sun Y, Lu Y, Jiang X, Ma B, Yu L, Zhang J, Dong X, Zhang Q.   +8 more
europepmc   +2 more sources

Regulatory Mechanism of M1/M2 Macrophage Polarization in the Development of Autoimmune Diseases

Mediators of Inflammation, Volume 2023, Issue 1, 2023., 2023
Macrophages are innate immune cells in the organism and can be found in almost tissues and organs. They are highly plastic and heterogeneous cells and can participate in the immune response, thereby playing a crucial role in maintaining the immune homeostasis of the body.
Yuan Peng, Mengxian Zhou, Hong Yang, Ruyi Qu, Yan Qiu, Jiawen Hao, Hongsheng Bi, Dadong Guo, Paola Migliorini   +8 more
wiley   +1 more source

Identifying the Effect of COVID‐19 Infection in Multiple Myeloma and Diffuse Large B‐Cell Lymphoma Patients Using Bioinformatics and System Biology

Computational and Mathematical Methods in Medicine, Volume 2022, Issue 1, 2022., 2022
The severe acute respiratory syndrome coronavirus type 2 (SARS‐CoV‐2), also referred to as COVID‐19, has spread to several countries and caused a serious threat to human health worldwide. Patients with confirmed COVID‐19 infection spread the disease rapidly throughout the region.
Chengcheng Li, Ying Zhang, Yingying Xiao, Yun Luo, Giulia Fiscon   +4 more
wiley   +1 more source

Liensinine Inhibits Osteosarcoma Growth by ROS‐Mediated Suppression of the JAK2/STAT3 Signaling Pathway

Oxidative Medicine and Cellular Longevity, Volume 2022, Issue 1, 2022., 2022
Osteosarcoma (OS) is the most common malignancy of bone. Liensinine exerts antitumor effects on cancers of the colon, breast, and gallbladder. However, its antitumor activity in OS remains unclear. This study is aimed at investigating the efficacy of liensinine against OS and the underlying mechanism of action.
Fei Jia, Yu Liu, Xinyu Dou, Chuanchao Du, Tianli Mao, Xiaoguang Liu, Peichao Chen   +6 more
wiley   +1 more source

STAT3 and its targeting inhibitors in osteosarcoma

Cell Proliferation, Volume 54, Issue 2, February 2021., 2021
Signal transducer and activator of transcription 3 (STAT3) is a member of the STAT protein family, vitally important for eukaryotic cells. We review the molecular structure and function of STAT3 and its isoforms, highlighting signalling pathways for the regulation of gene transcription. A critical appraisal of STAT3 in cancers, such as osteosarcoma, is
Yun Liu, Shijie Liao, Samuel Bennett, Haijun Tang, Dezhi Song, David Wood, Xinli Zhan, Jiake Xu   +7 more
wiley   +1 more source

Anti-Hepatoma Activity of a Novel Compound Glaucocalyxin H In Vivo and In Vitro [PDF]

AAPS PharmSciTech, 2014
Glaucocalyxin H (GLH) is a new compound isolated from a traditional Chinese medical herb Isodon japonica var. glaucocalyx which has been used for folk medicine. This study was carried out for the first time to investigate the potential role of GLH in anti-hepatoma activity and underlying mechanisms in it.
Guangfan, Hai, Chong, Zhang, Yanlong, Jia, Suping, Bai, Jinfen, Han, Lanqing, Guo, Taizhen, Cui, Bingxuan, Niu, Feng, Huang, Yu, Song   +9 more
openaire   +2 more sources

An Up-to-Date Review of Traditional Chinese Medicine in the Treatment of Atherosclerosis: Components, Mechanisms, and Therapeutic Potentials. [PDF]

Phytother Res
Traditional Chinese medicine in atherosclerosis: multi‐target modulation of pathogenesis. ABSTRACT Atherosclerosis is a chronic inflammatory disease and a major global health concern. In recent years, traditional Chinese medicines (TCMs) have demonstrated multi‐target therapeutic potential against atherosclerosis by modulating inflammatory responses ...
Nijat D, Zhao Q, Abdurixit G, He J, Liu H, Li J.   +5 more
europepmc   +2 more sources

Glaucocalyxin a protect liver function via inhibiting platelet over-activation during sepsis

Phytomedicine, 2022
Rabdosia japonica (Burm. f.) var. glaucocalyx (Maxim.) is a perennial herb, and is traditionally used as folk medicine for treating inflammatory diseases and cancer. Gaucocalyxin A (GLA) is an ent‑kaurane diterpenoid that is isolated from the aerial parts of R. japonica (Burm. f.) var. glaucocalyx (Maxim.). In a recent study, we found that GLA protects
Jiang Jiang, Dengping Liu, Yuanyuan Wang, Wei Li, Zhihui Hong, Jianzhong An, Shigang Qiao, Zhanli Xie   +7 more
openaire   +4 more sources

Comparative transcriptome analysis of roots, stems and leaves of Isodon amethystoides reveals candidate genes involved in Wangzaozins biosynthesis

BMC Plant Biology, 2018
Background Isodon amethystoides (Ben-th) Cy Wu et Hsuan is an important traditional medicinal plant endowed with pharmacological properties effective in the treatment of various diseases, including pulmonary tuberculosis.
Fenglan Zhao, Mengchu Sun, Wanjun Zhang, Chunli Jiang, Jingtong Teng, Wei Sheng, Mingzhi Li, Aimin Zhang, Yongbo Duan, Jianping Xue   +9 more
doaj   +1 more source