Results 31 to 40 of about 114,625,331 (143)

Ellagic acid protects dopamine neurons from rotenone‐induced neurotoxicity via activation of Nrf2 signalling

Journal of Cellular and Molecular Medicine, Volume 24, Issue 16, Page 9446-9456, August 2020., 2020
Abstract Parkinson's disease (PD) is the second most prevalent central nervous system (CNS) degenerative disease. Oxidative stress is one of key contributors to PD. Nuclear factor erythroid‐2‐related factor 2 (Nrf2) is considered to be a master regulator of many genes involved in anti‐oxidant stress to attenuate cell death.
Yi‐zheng Wei, Guo‐fu Zhu, Chang‐qing Zheng, Jing‐jie Li, Shuo Sheng, Dai‐di Li, Guo‐qing Wang, Feng Zhang   +7 more
wiley   +1 more source

An ent-kaurane diterpenoid from Isodon japonica var. glaucocalyx

Acta Crystallographica Section E, 2009
The title compound, 14β-acetoxy-7α-hydroxy-ent-kaur-16-ene-3,15-dione or glaucocalyxin B, C22H30O5, a natural ent-kaurane diterpenoid, is composed of four rings with the expected cis and trans ring junctions.
Su-Ping Bai, Guo-Sheng Luo, Xiao-Yi Zhang, Wei Liu   +3 more
doaj   +1 more source

Pretreatment of Ascorbic Acid Inhibits MPTP‐Induced Astrocytic Oxidative Stress through Suppressing NF‐κB Signaling

Neural Plasticity, Volume 2020, Issue 1, 2020., 2020
Astrocytes are a major constituent of the central nervous system (CNS). Astrocytic oxidative stress contributes to the development of Parkinson’s disease (PD). Maintaining production of antioxidant and detoxification of reactive oxygen and nitrogen species (ROS/RNS) in astrocytes is critical to prevent PD.
Xiaokang Zeng, Kai Xu, Ji Wang, Yunqi Xu, Shaogang Qu, Fushun Wang   +5 more
wiley   +1 more source

Synthesis and in vitro anticancer activities of biotinylated derivatives of glaucocalyxin A and oridonin

Journal of Asian Natural Products Research, 2020
Fourteen glaucocalyxin A biotinylated derivatives, one glaucocalyxin C biotinylated derivative, and two oridonin biotinylated derivatives were designed and synthesized. Their structures were confirmed from 1H NMR, 13C NMR and HRMS data. The derivatives were evaluated for cytotoxic activities against lung (A549), cervical cancer cell line HeLa ...
Xiao-Lei, Huang, Jing-Lei, Chen, Xian-Lun, Li, Lei, Zhao, Ya-Dong, Cui, Jiang-Yun, Liu, Susan L, Morris-Natschke, Goto, Masuo, Yung-Yi, Cheng, Kuo-Hsiung, Lee, Dao-Feng, Chen, Jian, Zhang   +11 more
openaire   +2 more sources

Glaucocalyxin B induces apoptosis and autophagy in human cervical cancer cells

Molecular Medicine Reports, 2016
Glaucocalyxin (Gln), an ent‑kaurane diterpenoid isolated from the Chinese traditional medicine, Rabdosia japonica, represents a novel class of anticancer drugs. GlnA is one of the three major forms of Gln and has demonstrated potent anticancer effects in a variety of cancer types.
Ying, Pan, Jieyu, Bai, Fangfang, Shen, Li, Sun, Quanzhong, He, Bing, Su   +5 more
openaire   +3 more sources

Advanced Role of Neutrophils in Common Respiratory Diseases

Journal of Immunology Research, Volume 2017, Issue 1, 2017., 2017
Respiratory diseases, always being a threat towards the health of people all over the world, are most tightly associated with immune system. Neutrophils serve as an important component of immune defense barrier linking innate and adaptive immunity. They participate in the clearance of exogenous pathogens and endogenous cell debris and play an essential
Jinping Liu, Zhiqiang Pang, Guoqiang Wang, Xuewa Guan, Keyong Fang, Ziyan Wang, Fang Wang, Michael Schnoor   +7 more
wiley   +1 more source

Transforming Growth Factor‐Beta Signaling in Cancer: Therapeutic Implications, Challenges, and Pathways to Progress

MedComm – Oncology, Volume 4, Issue 3, September 2025.
TGF‐β inhibition is emerging as a promising cancer therapy, yet translating laboratory success to bedside implementation has suffered significant setbacks. The associated challenges include adverse drug reactions, inadequate predictive models, and activation of alternative signaling pathways.
Faizah A. Alabi, Izuchukwu F. Okpalanwaka, Adenike Oyegbesan, Ebenezar Okoyeocha, Mariam Oladejo, Sikiru O. Imodoye   +5 more
wiley   +1 more source

Natural Products for Antithrombosis

Evidence-Based Complementary and Alternative Medicine, Volume 2015, Issue 1, 2015., 2015
Thrombosis is considered to be closely related to several diseases such as atherosclerosis, ischemic heart disease and stroke, as well as rheumatoid arthritis, hyperuricemia, and various inflammatory conditions. More and more studies have been focused on understanding the mechanism of molecular and cellular basis of thrombus formation as well as ...
Cen Chen, Feng-Qing Yang, Qian Zhang, Feng-Qin Wang, Yuan-Jia Hu, Zhi-Ning Xia, Angelo A. Izzo   +6 more
wiley   +1 more source

Rabdosia japonica var. glaucocalyx Flavonoids Fraction Attenuates Lipopolysaccharide‐Induced Acute Lung Injury in Mice

Evidence-Based Complementary and Alternative Medicine, Volume 2014, Issue 1, 2014., 2014
Rabdosia japonica var. glaucocalyx (Maxim.) Hara, belonging to the Labiatae family, is widely used as an anti‐inflammatory and antitumor drug for the treatment of different inflammations and cancers. Aim of the Study. To investigate therapeutic effects and possible mechanism of the flavonoids fraction of Rabdosia japonica var. glaucocalyx (Maxim.) Hara
Chun-jun Chu, Nai-yu Xu, Xian-lun Li, Long Xia, Jian Zhang, Zhi-tao Liang, Zhong-zhen Zhao, Dao-feng Chen, Shi-Biao Wu   +8 more
wiley   +1 more source

Inhibition Peroxiredoxin‐2 by Capsaicin Ameliorates Rheumatoid Arthritis via ROS‐Mediated Apoptosis in Fibroblast‐Like Synoviocytes

MedComm, Volume 6, Issue 6, June 2025.
Capsaicin attenuating arthritis by inhibiting AKT phosphorylation and activating the NRF2–HO‐1 axis via targeting PRDX2 ABSTRACT Rheumatoid arthritis (RA), a prevalent and incurable autoimmune disease globally, is characterized by the immune system attacking the body's own tissues, leading to joint inflammation and damage.
Hengkai He, Mingjing Hao, Piao Luo, Junhui Chen, Yehai An, Jingnan Huang, Ruiyi He, Qingfeng Du, Qian Zhang, Jigang Wang   +9 more
wiley   +1 more source