Anti-inflammatory effects of glaucocalyxin B in microglia cells [PDF]
Journal of Pharmacological Sciences, 2015 Over-activated microglia is involved in various kinds of neurodegenerative process including Parkinson, Alzheimer and HIV dementia. Suppression of microglial over activation has emerged as a novel strategy for treatment of neuroinflammation-based ...
Ping Gan +10 more
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Glaucocalyxin A alleviates inflammatory response in rats with traumatic fracture [PDF]
Jichu yixue yu linchuangObjective To investigate whether glaucocalyxin A can reduce inflammatory response in rats with traumatic fracture. Methods The rats were randomly divided into control group, model group, low GLA (GLA-L), high GLA dose group (GLA-H) and GLA-H+YC-1 (HIF ...
JIANG Bowen, MA Rui, WANG Peng, QU Zhe, LI Aiqun
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Total Synthesis of (−)‐Glaucocalyxin A [PDF]
Angewandte Chemie, 2020 AbstractA practically useful method for the formation of the highly oxygenated bicyclo[3.2.1]octane ring system through Mn(OAc)3‐mediated radical cyclization of alkynyl ketones was developed, which opens up a new avenue for the total synthesis of a number of highly oxidized diterpenoids. Application of this method enabled the first total synthesis of (−
Jiuzhou Guo +4 more
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Food Frontiers, 2023 Chronic obstructive pulmonary disease (COPD) is an irreversible disease with the leading causes of morbidity, mortality, and several physical limitations. Isodon Suzhouensis is a unique Chinese medicinal plant used for both medicine and food.
Kefeng Zhai +10 more
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Glaucocalyxin B Alleviates Lipopolysaccharide-Induced Parkinson’s Disease by Inhibiting TLR/NF-κB and Activating Nrf2/HO-1 Pathway [PDF]
Cellular Physiology and Biochemistry, 2017 Background/Aims: Parkinson’s disease (PD) is a common neurodegenerative disease in the old population, characterized by dopaminergic neuron loss, inflammation and oxidative stress injury in the substantia nigra.
Wei Xu +5 more
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PLoS ONE, 2013 Microglial cells are the resident macrophages and intrinsic arm of the central nervous system innate immune defense. Microglial cells become activated in response to injury, infection, environmental toxins, and other stimuli that threaten neuronal ...
Byung-Wook Kim +7 more
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Glaucocalyxin A Attenuates IL-1β-Induced Inflammatory Response and Cartilage Degradation in Osteoarthritis Chondrocytes via Inhibiting the Activation of NF-κB Signaling Pathway. [PDF]
Dis Markers, 2022 Glaucocalyxin A (GLA) is a bioactive natural compound with anti‐inflammatory activity. Herein, the role of GLA in osteoarthritis (OA) was evaluated. Our results demonstrated that the IL‐1β‐induced inducible nitric oxide synthase (iNOS) and cyclooygenase‐2 (COX‐2) expression, two enzymes resulting in the release of nitric oxide (NO) and PGE2, were also ...
Zhu W, Zhang Y, Li Y, Wu H.
europepmc +2 more sources
Glaucocalyxin B Attenuates Ovarian Cancer Cell Growth and Cisplatin Resistance In Vitro via Activating Oxidative Stress. [PDF]
Oxid Med Cell Longev, 2022 Ovarian cancer is one of the fatal gynecological cancers around the world. Cisplatin is the first‐line chemotherapy drug for the clinical treatment of ovarian cancer. However, many patients with ovarian cancer are still suffering from resistance to cisplatin.
Zhang T +11 more
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Glaucocalyxin A Attenuates Allergic Responses by Inhibiting Mast Cell Degranulation through p38MAPK/NrF2/HO-1 and HMGB1/TLR4/NF-κB Signaling Pathways. [PDF]
Evid Based Complement Alternat Med, 2021 Glaucocalyxin A (GLA) has various pharmacological effects like antioxidation, immune regulation, and antiatherosclerosis. Here, in this study, the effect and mechanism of GLA on mast cell degranulation were studied. The results of the anti‐DNP IgE‐mediated passive cutaneous anaphylaxis (PCA) showed that GLA dramatically inhibited PCA in vivo, as ...
Piao Y +10 more
europepmc +2 more sources
Effect of glaucocalyxin B on the protein expressions of PTEN, Beclin1 and LC3 in a mouse model of transplanted cervical cancer, and its significance [PDF]
, 2022 Purpose: To determine the effect of glaucocalyxin B (GLB) on the protein expressions of PTEN, Beclin1 and LC3 in a mouse model of transplanted cervical cancer, and its significance.Methods: A mouse model of transplanted cervical cancer was established in
Yang, Feixiang +3 more
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