Glaucocalyxin A Protects H9c2 Cells Against Hypoxia/Reoxygenation-Induced Injury Through the Activation of Akt/Nrf2/HO-1 Pathway [PDF]
Cell Transplantation, 2020 Myocardial infarction (MI) is one of the most serious cardiovascular diseases associated with myocardial ischemia/reperfusion (I/R) injury. Glaucocalyxin A (GLA) is a biologically active ent-kauranoid diterpenoid that has been found to ameliorate ...
Hai Wang, Xiaoyan Dang, Longfei Pan
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Glaucocalyxin A suppresses multiple myeloma progression in vitro and in vivo through inhibiting the activation of STAT3 signaling pathway [PDF]
Cancer Cell International, 2021 Background Multiple myeloma (MM) is the most common malignant hematological disease in the people worldwide. Glaucocalyxin A (GLA) is a bioactive ent-kauranoid diterpenoid, that is derived from Rabdosia japonica var. GLA has been demonstrated that it had
Mei Li +7 more
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Glaucocalyxin A Inhibits the Malignancies of Gastric Cancer Cells by Downregulating MDM2 and RNF6 via MiR-3658 and the SMG1-UPF mRNA Decay Pathway [PDF]
Frontiers in Oncology, 2022 Gastric cancer (GC) ranks as the most common gastrointestinal cancer and is among the leading causes of cancer death worldwide. Glaucocalyxin A (GLA), an entkauranoid diterpene isolated from Rab-dosia japonica var., possesses various bioactivities.
Yanqi Liu +3 more
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Protective effects of glaucocalyxin A on the airway of asthmatic mice [PDF]
Open Medicine, 2022 The aim of this study is to investigate the protective effects of glaucocalyxin A (GLA) on airways in mouse models of asthma, concerning the inflammatory mediators, Th1/Th2 subgroup imbalance, and Toll-like receptor 4 (TLR4)/NF-κB signaling pathway ...
Chen Si +11 more
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Glaucocalyxin A Inhibits the Malignant Progression of Epithelial Ovarian Cancer by Affecting the MicroRNA-374b-5p/HMGB3/Wnt-β-Catenin Pathway Axis [PDF]
Frontiers in Oncology, 2022 ObjectiveGlaucocalyxin A (GLA) is an ent-kaurene diterpenoid from Rabdosia japonica var possessing anti-tumor activity. This study aimed to investigate effects of GLA on epithelial ovarian cancer (EOC) and elucidate underlying mechanisms.MethodsThe ...
Feng Chen +6 more
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Glaucocalyxin A enhances colonic anastomotic healing after ischemia–reperfusion: experimental findings [PDF]
Acta Cirúrgica BrasileiraPurpose: Glaucocalyxin A (GLA), a diterpenoid with antioxidative and anti-inflammatory properties, has shown vascular protective effects in preclinical models.
Mehmet Algül +5 more
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Glaucocalyxin A alleviates ulcerative colitis by inhibiting PI3K/AKT/mTOR signaling [PDF]
Scientific ReportsIsodon japonicus (Burm.f.) Hara var. glaucocalyx (Maxim.) Hara is a herbaceous perennial plant. Historically, it has often been used to treat dysentery and other diseases, indicating its potential efficacy in the treatment of inflammatory conditions ...
Tongtong Zhou +9 more
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Glaucocalyxin A delays the progression of OA by inhibiting NF-κB and MAPK signaling pathways [PDF]
Journal of Orthopaedic Surgery and ResearchBackground Osteoarthritis (OA) is a common degenerative joint condition marked by inflammation and cartilage breakdown. Currently, there is a dearth of treatment medications that can clearly slow the course of OA.
Xin Hong +8 more
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Drug Delivery, 2019 Glaucocalyxin A (GLA), is a diterpenoid extracted from Hara and has been studied for decades for its diverse bioactivities. However, GLA presents poor solubility in water and low bioavailability through oral administration which has hindered its ...
Lili Ren, Jingjing Wang
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Glaucocalyxin A inhibits platelet activation and thrombus formation preferentially via GPVI signaling pathway. [PDF]
PLoS ONE, 2013 Platelets play a pivotal role in atherothrombosis and the antiplatelet agents have been proved to be useful in preventing onset of acute clinical events including myocardial infarction and stroke.
Wei Li +9 more
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