Results 41 to 50 of about 21,105,669 (168)
Anti-Hepatoma Activity of a Novel Compound Glaucocalyxin H In Vivo and In Vitro [PDF]
AAPS PharmSciTech, 2014 Glaucocalyxin H (GLH) is a new compound isolated from a traditional Chinese medical herb Isodon japonica var. glaucocalyx which has been used for folk medicine. This study was carried out for the first time to investigate the potential role of GLH in anti-hepatoma activity and underlying mechanisms in it.
Guangfan, Hai +9 more
openaire +2 more sources
Functional role of MicroRNA/PI3K/AKT axis in osteosarcoma [PDF]
, 2023 Osteosarcoma (OS) is a primary malignant bone tumor that occurs in children and adolescents, and the PI3K/AKT pathway is overactivated in most OS patients.
Jia Liu +3 more
core +1 more source
Glaucocalyxin A, a negative Akt regulator, specifically induces apoptosis in human brain glioblastoma U87MG cells [PDF]
Acta Biochimica et Biophysica Sinica, 2013 Akt is becoming an attractive target in the development of anti-tumor agents. In the present study, we aimed to discover novel negative Akt regulators against malignant glioma. An Akt regulator screening platform performed in an Akt-GFP overexpression cell line was developed, and natural product library was screened and evaluated using this platform ...
Xian, Xiao +9 more
openaire +2 more sources
Journal of Cellular and Molecular Medicine, Volume 24, Issue 16, Page 9446-9456, August 2020., 2020 Abstract Parkinson's disease (PD) is the second most prevalent central nervous system (CNS) degenerative disease. Oxidative stress is one of key contributors to PD. Nuclear factor erythroid‐2‐related factor 2 (Nrf2) is considered to be a master regulator of many genes involved in anti‐oxidant stress to attenuate cell death.
Yi‐zheng Wei +7 more
wiley +1 more source
, 2023 Ent-kaurenes consist of an ABC-ring based on a trans-anti-hydrophenanthrene skeleton and a D ring with an exomethylene. Highly oxygen-functionalized ent-kauren-15-ones have promising antiinflammatory pharmacological activity.
Ikeda, Wataru +4 more
core +2 more sources
Neural Plasticity, Volume 2020, Issue 1, 2020., 2020 Astrocytes are a major constituent of the central nervous system (CNS). Astrocytic oxidative stress contributes to the development of Parkinson’s disease (PD). Maintaining production of antioxidant and detoxification of reactive oxygen and nitrogen species (ROS/RNS) in astrocytes is critical to prevent PD.
Xiaokang Zeng +5 more
wiley +1 more source
An ent-kaurane diterpenoid from Isodon japonica var. glaucocalyx
Acta Crystallographica Section E, 2009 The title compound, 14β-acetoxy-7α-hydroxy-ent-kaur-16-ene-3,15-dione or glaucocalyxin B, C22H30O5, a natural ent-kaurane diterpenoid, is composed of four rings with the expected cis and trans ring junctions.
Su-Ping Bai +3 more
doaj +1 more source
Síntese de derivados do diterpeno ent-3β-hidróxi-caur-16-eno com promissoras atividades biológicas [PDF]
, 2023 Medicines are becoming increasingly obsolete with the rise of increasingly resistant pathogens, being a real challenge in the treatment and prevention of infections, what requires a constant search for new and more active antimicrobial drugs.
Auzier, Jéssica Fernandes
core
Development of three dimensional and in vivo modelling systems for the overexpression of Active-β-catenin in osteosarcoma [PDF]
, 2023 Introduction: Osteosarcoma (OS) is a primary bone malignancy most commonly found in children and adolescents. The 5-year survival rate for OS is 60%, which decreases to 27% when distant metastases are present.
Hinton, Kristin M
core +2 more sources
Plant-derived natural products as leads to antitumor drugs [PDF]
, 2014 Cancer is the main cause of death worldwide. Chemotherapeutic agents used for disease treatments have shown limited antitumor activity, with a high recurrence rate. It has prompted the research efforts to identify anti-tumor compounds.
Sun, Hui +4 more
core +2 more sources