Advanced Science, EarlyView.A cascade recognition of activatable probe ANG‐hCy‐MC is used for high‐precision depiction of glioblastoma (GBM) margin. This probe crosses the blood‐brain barrier (BBB) through LRP1 receptor‐mediated transport and provides excellent fluorescence signal contrast between the tumor and normal tissues, thereby enabling ultra‐selective imaging and precise ...
Xinru An +8 more
wiley +1 more source
The regenerative period of somatosensory nerves is closed by a DCC signaling axis. [PDF]
PLoS GenetHammer J, Smith CJ.
europepmc +1 more source
Advanced Science, EarlyView.Resident myonuclei are the molecular “control centers” for large multinuclear muscle fibers. It is presumed that, with aging, these control centers become compromised and contribute to delayed or blunted muscle adaptive potential. This study is a detailed roadmap that exposes how young versus aged myonuclei respond to a hypertrophic loading stimulus ...
Pieter J. Koopmans +8 more
wiley +1 more source
Extracellular Vesicles in Autoimmune Diseases: From Diagnostic Biomarkers to Engineered Therapeutics
Advanced Science, EarlyView.This review provides a systematic comparison of extracellular vesicles (EVs) from both mammalian and plant sources in the context of autoimmune diseases. It highlights their emerging roles as precision biomarkers and engineered therapeutic platforms.
Yufei Wu +6 more
wiley +1 more source
Single-cell RNA sequencing suggests different progenitor lineages between <i>IDH</i> mutant and <i>IDH</i>wt glioma. [PDF]
Neurooncol AdvAlnahhas I, Kayne A, Khan MM, Shi W.
europepmc +1 more source
Advanced Science, EarlyView.A biomimetic Prussian White nanoparticle (PW) is engineered to achieve long‐term local retention and orchestrate immunometabolic‐epigenetic remodeling for sciatic nerve regeneration. PW directly targets hexokinase 2 to suppress glycolysis, thereby elevating α‐ketoglutarate and driving Kdm4a/b‐mediated demethylation of H3K9me3.
Wenying Xu +6 more
wiley +1 more source
Radial glial cells and glioblastoma: how developmental neurobiology can inform our understanding of brain cancer initiation, treatment resistance, and resilience. [PDF]
Transl OncolLove CA +4 more
europepmc +1 more source
ALKBH3 m1A Demethylase Deficiency Reduces Alzheimer's Amyloid‐β Pathology
Advanced Science, EarlyView.This study identifies that ALKBH3‐driven m1A demethylation orchestrates Alzheimer's disease progression by disrupting mitochondrial and synaptic homeostasis. This epitranscriptomic mechanism suppresses PINK1‐mediated mitophagy via m1A erasure, leading to mitochondrial dysfunction, oxidative stress, elevated Aβ production, and impaired microglial ...
Yueyang Li +25 more
wiley +1 more source
Conservation of glial density and cell-type ratios within a brain region across mammals. [PDF]
PNAS NexusPinto-Duarte A +3 more
europepmc +1 more source
An ultrastructural map of a spinal sensorimotor circuit reveals the potential of astroglia modulation. [PDF]
Cell RepKoh ZM +8 more
europepmc +1 more source