Results 141 to 150 of about 70,938 (290)

Updating Traumatic Brain Injury Classification for Surgeons: Integrating the CBI‐M Framework Into Trauma and Acute Care Practice

World Journal of Surgery, EarlyView.
Traumatic brain injury (TBI) remains a major cause of death and disability worldwide. Traditional classification based on the Glasgow Coma Scale (GCS) provides a shared clinical language but insufficiently captures the biological heterogeneity, imaging variability, and contextual modifiers that influence outcomes.
Ruben Peralta, Santiago Cardona‐Collazos, Ali Msheik, Wendy D. Gonzalez, Andrés Salazar Restrepo, Laura M. Loaiza‐Cardona, Andres M. Rubiano   +6 more
wiley   +1 more source

Minocycline and bone marrow–derived mononuclear cells as potential therapeutics for hereditary retinal degenerations

Acta Ophthalmologica, EarlyView.
Abstract Purpose To assess in Royal College of Surgeons (RCS) rats if the combination of two previously documented neuroprotective strategies: minocycline administration and bone marrow–derived mononuclear cells (BM‐MNCs) intravitreal transplantation, offers enhanced neuroprotection compared with each treatment alone.
Alba Videla‐Ristol, Ana Martínez‐Vacas, David García‐Bernal, Manuel Vidal‐Sanz, María Paz Villegas‐Pérez, Diego García‐Ayuso, Johnny Di Pierdomenico   +6 more
wiley   +1 more source

Efeito do ácido fólico e da homocisteína sobre os processos de proliferação e diferenciação celular no telencéfalo de embriões de Gallus domesticus [PDF]

, 2013
TCC(graduação) - Universidade Federal de Santa Catarina. Centro de Ciências Biológicas. Biologia.Micronutrientes são vitaminas e minerais obtidos da dieta, necessários para o crescimento, manutenção e reprodução dos indivíduos.
Cecchini, Manuela Sozo
core  

Elevated Serum Neurofilament Light Chain Is Associated With Systemic Inflammation in Very Preterm Infants

Acta Paediatrica, EarlyView.
ABSTRACT Aim Neurofilament light chain (NFL) and glial fibrillary acidic protein (GFAP) are known biomarkers of brain injury in adults, but their significance in very preterm (VPT) infants remains unclear. Given the strong link between inflammation, oxidative stress, and brain injury in this population, we investigated associations between NFL, GFAP ...
E.‐V. Kivivuori, S.‐K. Herukka, S. Kärkkäinen, T. Kokkola, J. Kirjavainen, U. Sankilampi   +5 more
wiley   +1 more source

Serum glial fibrillary acidic protein predicts disease progression in multiple sclerosis

Annals of Clinical and Translational Neurology
Objective Glial fibrillary acidic protein (GFAP) is expressed in astrocytes and may be a useful marker of non‐active progressive multiple sclerosis (MS).
Evan Madill, Brian C. Healy, Negar Molazadeh, Mariann Polgar‐Turcsanyi, Bonnie I. Glanz, Howard L. Weiner, Tanuja Chitnis   +6 more
doaj   +1 more source

Increased expression of inflammasome signaling genes and proteins in selective brain regions in the intermediate stage of Alzheimer's disease

Brain Pathology, EarlyView.
Neuritic plaques increase in the intermediate stage of Alzheimer's neuropathological change. The intermediate stage of Alzheimer's disease was investigated by transcriptomics and immunohistochemistry. This revealed that inflammasome sensors NLRP1, NLRP3, and AIM2 oligomerize with ASC speck to form the inflammasome complex and initiate the downstream ...
Juan Pablo de Rivero Vaccari, David A. Davis, Andrew P. Sawaya, Susanna P. Garamszegi, Xiaoyan Sun, Ayled Barreda, Helen M. Bramlett, Sakir Humayun Gultekin, W. Dalton Dietrich, Robert W. Keane, Regina T. Vontell   +10 more
wiley   +1 more source

Glial fibrillary acidic protein in fibromyalgia: its serum levels and antibodies

Advances in Rheumatology
Background Fibromyalgia is a stress-related disorder in which dorsal root ganglia (DRG) may play an important pathogenic role. DRG exhibit unique stress-induced, pro-algesic physio-anatomy, where each pain-sensing nerve fiber soma is encased and ...
Felipe Massó, Laura-Aline Martínez-Martínez, Luis M. Amezcua-Guerra, Francisco Mercado, Angélica Almanza, Manuel Martínez-Lavín   +5 more
doaj   +1 more source

Proteomic profile of CSF obtained at the time of diagnosis determines amyotrophic lateral sclerosis progression and survival: CXCL7 levels in disease prognosis and survival

Brain Pathology, EarlyView.
Untargeted multiomic profiling of cerebrospinal fluid reveals that proteomic, but not lipidomic, signatures robustly distinguish ALS patients from controls and stratify individuals by survival, highlighting marked molecular differences between short survival and long survival disease.
Sergio Roca‐Pereira, Yaiza López‐Sampere, Pol Mengod‐Soler, Mario Peña‐Fonteboa, Carla Marco, Alejandro Caravaca‐Puchades, Raúl Domínguez, Juan Francisco Vázquez‐Costa, Enrique Santamaría, Joaquín Fernández‐Irigoyen, María J. Colomina, Isabel León Moreno, Antonio Martínez Yélamos, Sergio Martínez Yélamos, Gabriel Santpere, Elia Obis, Manuel Portero‐Otín, Gerard Piñol‐Ripoll, Mónica Povedano, Pol Andrés‐Benito   +19 more
wiley   +1 more source

GLIAL FIBRILLARY ACIDIC PROTEIN SEBAGAI PREDIKTOR KEMATIAN CIDERA KEPALA

, 2013
The incidence of head injury due to trauma increases the morbidity and mortality is relatively high, thus requiring a fast and precise handling to get a good clinical output.
, dr. Usi Sukorini, M.Kes, Sp.PK-K, , Wahid Syamsul Hadi   +1 more
core  

Clinical and molecular features of primary gliosarcoma with digital spatial whole‐transcriptome analysis of glial and mesenchymal components

Brain Pathology, EarlyView.
We report the clinical and genetic features of an institutional cohort of primary adult gliosarcomas compared to glioblastoma. We performed spatial whole‐transcriptome analysis on glial and sarcomatous regions of four cases to compare gene expression profiles and validated differential protein expression for two markers in tissue sections.
Matthew D. Wood, Gabriel Zangirolani, Jinho Lee, Melanie H. Hakar, Tanaya Neff, Kevin Y. Zhang, Christopher L. Corless   +6 more
wiley   +1 more source