Results 61 to 70 of about 2,551 (122)

Dipeptidyl Peptidase‐4 Inhibitors Associated Heart Failure Events in Adult Patients With Type‐2 Diabetes Mellitus Treated With Dipeptidyl Peptidase‐4 Inhibitors: A Systematic Review and Meta‐Analysis

Endocrinology, Diabetes &Metabolism, Volume 9, Issue 5, September 2026.
DPP‐4 Inhibitors associated withheart failure events in patients with type‐2 diabetes. This study found statistically insignificant summary effect for all DPP‐4 inhibitors combined but found asignificant association of saxagliptin with heart failure events (RR = 1.24, 95% CI 1.05–1.47). Results are to be interpreted with caution.
Shishir Nepal, Shiva Prasad Nepal
wiley   +1 more source

Impact of Semaglutide, Liraglutide and Tirzepatide on Cardiometabolic Outcomes: A Comparative Narrative Review

Endocrinology, Diabetes &Metabolism, Volume 9, Issue 5, September 2026.
The comparative pharmacology and cardiometabolic outcomes of semaglutide, liraglutide and tirzepatide, integrating evidence from major clinical trial programs and meta‐analyses. ABSTRACT Background Cardiometabolic disorders such as type 2 diabetes mellitus (T2DM), obesity and cardiovascular disease (CVD) remain major global health challenges.
Hiba Bawadi, Haya Abuhijleh, Mamon Nofal, Zain Z. Zakaria, Maha Al‐Asmakh   +4 more
wiley   +1 more source

Advantages of the combined therapy with metformin and glimepiride in patients with type 2 diabetes mellitus

Mìžnarodnij Endokrinologìčnij Žurnal, 2017
Background. The use of glimepiride in the therapy of type 2 diabetes mellitus (DM) fewer stimulates the pancreas, keeping its resource, and does not result in hyperinsulinemia, and also provides the highest profile of safety at the lowest stimulation ...
V.I. Pankiv
doaj   +1 more source

Personalized 3D‐Printed Affinisol‐Based Pharmaceutical Delivery Systems: The Case Study for Alternative Sulfonamides for Alzheimer's Disease

Macromolecular Bioscience, Volume 26, Issue 9, September 2026.
Personalized dosage forms engineered via hot‐melt extrusion and FDM 3D‐printing enable the evaluation of novel anti‐Alzheimer's compounds. The study integrates dissolution testing, thermo‐analytical profiling, physico‐chemical characterization, cytotoxicity, and stability to advance personalized medicine in drug development.
Marie Nevyhoštěná, Alena Komersová, Roman Svoboda, Vladimír Pejchal, Adéla Pospíšilová, Jan Muselík, Aleksandra Łapa, Paulina Koczurkiewicz‐Adamczyk   +7 more
wiley   +1 more source

Effects of glimepiride on the proliferation and differentiation of rat osteoblasts.

, 2014
A, Effect of glimepiride on proliferation of rat mandibular osteoblasts incubated with two different glucose concentrations (MTT assay).
Wei Xiong (58411), Jun Li (6494), Baosheng Tan (659133), Wei Geng (197192), Pan Ma (400070), Bin Gu (223694), Hongchen Liu (500623)   +6 more
core   +1 more source

Bioequivalence Study of a New Generic Fixed-Dose Combination of Sitagliptin (100 mg) and Glimepiride (2 mg) in Healthy Adult Volunteers under Fasting Condition

Chronicle of Diabetes Research and Practice
Introduction: The present study evaluated the bioequivalence of a fixed-dose combination (FDC) of sitagliptin and glimepiride with the originator reference product.
Prashant Kumthekar, Mihir Upadhyay, Koripalli S. Reddy, Sambasiva R. Puram, Basava S. Nallamekala   +4 more
doaj   +1 more source

A rapid hydrophilic interaction liquid chromatographic determination of glimepiride in pharmaceutical formulations

Saudi Pharmaceutical Journal, 2017
Glimepiride is one of the most widely prescribed antidiabetic drugs and contains both hydrophobic and hydrophilic functional groups in its molecules, and thus could be analyzed by either reversed-phase high performance liquid chromatography (HPLC) or ...
Si Zhou, Pengxiao Zuo, Yuegang Zuo, Yiwei Deng   +3 more
doaj   +1 more source

Sexual Safety Signals of Common Antidiabetic Drugs: Insights From FAERS Disproportionality Analysis

Andrology, Volume 14, Issue 6, Page 1627-1635, September 2026.
ABSTRACT Background Erectile dysfunction is a prevalent and distressing complication of diabetes mellitus that markedly affects quality of life in male patients. Although the role of diabetes in erectile dysfunction is well‐established, potential drug‐induced sexual dysfunction associated with commonly prescribed antidiabetic medications remains ...
Shan Lin, Xuefeng Ding, Xin Dang, Qingyuan Zhan   +3 more
wiley   +1 more source

Differential interaction of glimepiride and glibenclamide with the β-cell sulfonylurea receptor II [PDF]

, 1994
Glimepiride is a novel sulfonylurea for the treatment of type II-diabetic patients exhibiting different receptor binding kinetics to β-cell membranes with 8–9-fold higher koff rate and 2.5–3-fold higher kon rate compared to glibenclamide (see ...
Kramer, Werner, Kowalewski, Simone, Hartz, Detlev, Gutjahr, Ulrike, Summ, Hans-Dieter, Müller, Günter, Girbig, Frank, Werner Kramer, Hans-Dieter Summ, Frank Girbig, Ulrike Gutjahr, Detlev Hartz, Simone Kowalewski, Günter Müller   +13 more
core   +1 more source

Influence of type-4 dipeptidyl peptidase inhibition on endothelium-dependent relaxation of aortae from a db/db mouse model of type 2 diabetes: a comparison with the effect of glimepiride

Diabetes, Metabolic Syndrome and Obesity, 2019
Owen L Woodman,1 Jacinta M Ortega,1 Joanne L Hart,1 Thomas Klein,2 Simon Potocnik11School of Health and Biomedical Sciences, RMIT University, Bundoora, VIC, Australia; 2Department of Cardiometabolic Diseases Research, Boehringer Ingelheim Pharma ...
Woodman OL, Ortega JM, Hart JL, Klein T, Potocnik S   +4 more
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