Results 81 to 90 of about 2,551 (122)

Impact of Gliclazide Modified Release or Glimepiride as Add-on Therapy to Metformin on Glycemic and Oxidative Stress Parameters in Type 2 Diabetic Patients

Iraqi Journal of Pharmaceutical Sciences
Background: Type 2 diabetes mellitus is a condition characterized by an elevation of oxidative stress, which has been implicated in diabetic progression and its vascular complications.
Fadhel A. Shehab, Ali L. Jasim2, Adel Gh. Mohammed   +2 more
doaj   +1 more source

Comparison between the therapeutic effect of metformin, glimepiride and their combination as an add-on treatment to insulin glargine in uncontrolled patients with type 2 diabetes.

PLoS ONE, 2014
AimsTo compare the commonly prescribed oral anti-diabetic drug (OAD) combinations to use as an add-on therapy with insulin glargine in patients with uncontrolled type 2 diabetes despite submaximal doses of OADs.MethodsPeople with inadequately controlled ...
Cheol-Young Park, Jun Goo Kang, Suk Chon, Junghyun Noh, Seung Joon Oh, Chang Beom Lee, Sung Woo Park   +6 more
doaj   +1 more source

Andrographolide Pretreatment Enhances the Bioavailability and Hypoglycemic Action of Glimepiride and Metformin

, 2015
Herbal antidiabetic preparations are often used as an add-on therapy in diabetes. Hence, in the present investigation the effect of andrographolide (AD) on the pharmacokinetics and pharmacodynamics of glimepiride and metformin in normal as well as in STZ
Samala, Sujatha; University college of Pharmaceutical Sciences,Kakatiya University, Warangal TS 506009, Veeresham, Ciddi; University College of Pharmaceutical Sciences, Kakatiya University, Warangal, Telangana State - 506009, India   +1 more
core   +3 more sources

Bioequivalence assessment of the two brands of glimepiride tablets

, 2006
Background/Aim. Glimepiride, as an antidiabetic from the group of sulfonylurea, is administered perorally in the treatment of diabetes mellitus. The aim of this study was to compare pharmacokinetic profiles and relative bioavailabilities of the two oral ...
Milica Zlatkovic, Dusan Jovanovic, Miodrag Jovanovic, Jasmina Jovic-Stosic, Dragan Stojsic   +4 more
core   +1 more source

Development and Validation of UV Spectrophotometric methods for simultaneous estimation of Lobeglitazone Sulfate and Glimepiride in combined dosage form

Drug Analytical Research
Two UV spectrophotometric methods have been developed for accurately analyzing Lobeglitazone Sulfate and Glimepiride in combined dosage form, used in the treatment of type 2 diabetes mellitus. Method I, known as the simultaneous equation method (Vierodt’
Dhara Patel, Jeel Dobariya, Prasanna Pradhan, Grishma Patel, Dhananjay Meshram   +4 more
doaj   +1 more source

Effects of Metformin &/or Glimepiride on Resistin Level and Related Biochemical Markers in Type 2 Diabetes Mellitus

Al-Mustansiriyah Journal of Pharmaceutical Sciences, 2014
Resistin is a novel adipocyte-secreted hormone proposed to link obesity with diabetes in mice and may play a similar role in human. The aim of our study was to examine the relationship of serum resistin level to insulin resistance, and related ...
Hadeel Delman Najim, Ibrahim Adham Majeed, Abbas Mahdi Rahmah   +2 more
doaj   +1 more source

Effect of Metformin and Glimepiride on Liver and Kidney Functions in Alloxan-Induced Diabetic Rats

Journal of High Institute of Public Health, 2011
: Metformin and glimepiride have been marked as potential hypoglycemic agents for the treatment of type 2 diabetes. The purpose of this study was to investigate the effect of daily oral administration of metformin (500 mg/kg) or glimepiride (0.5 mg/kg)
Soheir E.M. Khadre, Hania M. lbrahim, Mahmoud B. Shabana, Nagwa A.A. EL-Seady   +3 more
doaj   +1 more source

Stimulation of a glycosyl-phosphatidylinositol-specific phospholipase by insulin and the sulfonylurea, glimepiride, in rat adipocytes depends on increased glucose transport [PDF]

, 1994
Korndörfer, Andrea, Bandlow, Wolfhard, Dearey, Elisabeth Ann, Müller, Günter   +3 more
core   +2 more sources

Glimepiride as insulin sensitizer: increased liver and muscle responses to insulin

, 2008
Aim: Glimepiride, a low-potency insulin secretagogue, is as efficient on glycaemic control as other sulphonylureas, suggesting an additional insulin-sensitizer role.
MACHADO, U. F., MORI, R. C. T., OKAMOTO, M. M., HIRABARA, S. M., HIRATA, A. E., Hirata, A. E. [UNIFESP]   +5 more
core   +1 more source

Mechanistic analysis of Zein nanoparticles/PLGA triblock in situ forming implants for glimepiride

International Journal of Nanomedicine, 2016
Osama Abdelhakim Aly Ahmed,1,2 Ahmed Samir Zidan,1,3 Maan Khayat4 1Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia; 2Department of Pharmaceutics and Industrial Pharmacy, Faculty ...
Ahmed OAA, Zidan AS, Khayat M
doaj