Results 131 to 140 of about 252,843 (247)

Harnessing ferroptosis to transform glioblastoma therapy and surmount treatment resistance. [PDF]

open access: yesCell Death Discov
Singh S   +7 more
europepmc   +1 more source

Fusidic Acid Reverses Chemoresistance in Breast Cancer via Targeting DDX6 to Downregulate GSK‐3β/β‐Catenin Signaling

open access: yesAdvanced Science, EarlyView.
FA directly binds to residue H378 of DDX6 and promotes its interaction with HSC70, leading to CMA degradation of DDX6, thereby impairing GSK‐3β/β‐catenin signaling, inhibiting ABC transporter proteins, and enhancing chemosensitivity. Abstract ABC transporter protein‐mediated drug efflux is a significant contributor to induced resistance in breast ...
Xiaxia Fan   +5 more
wiley   +1 more source

Expression of Glial Cell Line-derived Neurotrophic Factor and Its Receptors in Glioblastoma. [PDF]

open access: yesJ Histochem Cytochem
Ewald JD   +6 more
europepmc   +1 more source

GSK461364 Inhibits NLRP3 Inflammasome by Targeting NEK7 Phosphorylation

open access: yesAdvanced Science, EarlyView.
Schematic diagram of the mechanism by which GSK461364 inhibits NLRP3 inflammasome activation. GSK461364 inhibits the phosphorylation of NEK7 likely at serine 221 and serine 260 by suppressing the activity of PLK1, thereby restraining the formation of the NLRP3 inflammasome.
Ruiheng Luo   +13 more
wiley   +1 more source

From Bench to Bedside: Emerging Paradigms in CAR‐T Cell Therapy for Solid Malignancies

open access: yesAdvanced Science, EarlyView.
This review discusses emerging paradigms in CAR‐T cell therapy for solid tumors, emphasizing strategies to overcome therapeutic barriers through synthetic biology, immune engineering, and combinatorial approaches. It highlights advancements in logic gating, modulation of the immune microenvironment, and innovative cell designs, providing valuable ...
Yang Chen   +7 more
wiley   +1 more source

Uncertainty-aware ensemble of foundation models differentiates glioblastoma from its mimics. [PDF]

open access: yesNat Commun
Zhao J   +26 more
europepmc   +1 more source

Pharmacokinetics and Tolerance of Nicotinamide Combined with Radiation Therapy in Patients with Glioblastoma Multiforme [PDF]

open access: bronze, 1994
F. Cartei   +6 more
openalex   +1 more source

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