Results 111 to 120 of about 81,769 (261)

A 3D‐Engineered Conformal Implant Releases DNA Nanocomplexs for Eradicating the Postsurgery Residual Glioblastoma

Advanced Science, 2017
Gene therapy has great promise for glioblastoma treatment; however, it remains a great challenge to efficiently deliver genes to the brain. The incomplete resection of glioblastoma always leads to poor prognosis.
Yuan Yang, Ting Du, Jiumeng Zhang, Tianyi Kang, Li Luo, Jie Tao, Zhiyuan Gou, Shaochen Chen, Yanan Du, Jiankang He, Shu Jiang, Qing Mao, Maling Gou   +12 more
doaj   +1 more source

The efficacy of the therapy of glioblastoma and future opportunities

, 2018
A glioblastoma a leggyakoribb primer központi idegrendszeri malignitás felnőttekben. A kórismézésben bevezetésre került az integrált diagnózis fogalma, amely a tumor szövettani jellemzői mellett a molekuláris biológiai vizsgálatokat is figyelembe veszi ...
Tóth, Péter
core  

3D Bioprinted Glioblastoma Multiforme Models: How the Extracellular Matrix Glycosignature Influences Drug Response

Advanced Functional Materials, EarlyView.
Aberrant glycosylation in the glioblastoma tumor microenvironment drives therapeutic resistance. Here, a 3D bioprinted model was engineered by incorporating α‐NeuNAc‐(2→3)‐β‐D‐Gal‐ and chondroitin sulfate. Combined multiplex immunofluorescence and synchrotron‐based nanoCT analysis revealed that glycan‐matrix interactions dictate specific drug‐escape ...
Francesca Cadamuro, Marco Piazzoni, Ilaria Borghi, Alberto Baeri, Alessandro Fumagalli, Federica Perillo, Hafiz Muhammad Fahad, Martina Ghizzi, Luca Crippa, Gabriella Nicolini, Angela Bentivegna, Daniele Ramazzotti, Valentina Zuliani, Mirko Rivara, Carlo Giorgio Giussani, Andrea Di Cristofori, Guido Cavaletti, Federica Facciotti, Sobhan Sheikhi, Claire Seydoux, Murielle Salome, Peter Cloetens, Alberto Bravin, Paola Coan, Francesco Nicotra, Laura Russo   +25 more
wiley   +1 more source

Molecular determinants of the interaction between glioblastoma CD133+ cancer stem cells and the extracellular matrix

, 2020
Glioblastoma multiforme (GBM) is the most common primary tumor of the human brain. It is characterized by invasive growth and strong resistance to treatment, and the median survival time of patients is 15 months. The invasive growth of this tumor type is
Sharma, Aruna,, Arnotskaya, Natalia,, Natalia Arnotskaya, Bryukhovetskiy, Igor,, Andrey Bryukhovetskiy, Pak, Oleg,, Oleg Pak, Hari Shanker Sharma, Valeriy Shevchenko, Aruna Sharma, Igor Bryukhovetskiy, Khotimchenko, Yuri,, Bryukhovetskiy, Andrey,, Yuri Khotimchenko, Shevchenko, Valeriy,, Sharma, Hari Shanker,   +15 more
core   +1 more source

Engineered Microvascular Model of the Blood–Brain–Tumor Barrier Reveals Endothelial Remodeling in Diffuse Midline Glioma

Advanced Healthcare Materials, EarlyView.
We developed a patient‐derived, functional microfluidic model of the diffuse midline glioma (DMG) blood–brain–tumor barrier (BBTB) comprised of endothelial cells, astrocytes, pericytes, and tumor cells. The system forms perfusable microvasculature, reveals the BBTB retains vascular integrity, identifies DMG‐specific transcriptomic changes distinct from
Kimberly R. Bennett, Yann S. Vanrobaeys, Tessy Teboh, Zakiya Smith, Anderson Scott, Cynthia Hajal, Paula T. Hammond, Joelle P. Straehla   +7 more
wiley   +1 more source

How is Nanoarchitectonics Shaping Extracellular Vesicle Research?

Advanced Healthcare Materials, EarlyView.
The convergence of nanoarchitectonics and extracellular vesicle biology is reshaping next‐generation nanomedicine by enabling rationally designed nanostructures for enhanced EVs detection, engineering, and therapy. ABSTRACT Extracellular vesicles (EVs) have gained recognition as crucial mediators of cell‐to‐cell communication, holding immense potential
Madushani Dahanayake, Md Shahriar A. Hossain, Chia‐Hung Liu, Carlos Salomon, Yusuke Yamauchi, Mostafa Kamal Masud   +5 more
wiley   +1 more source

Glioblastoma with extracranial parotid, lymph node, and pulmonary metastases: a case report

Radiology Case Reports, 2019
We present a rare case of an isocitrate dehydrogenase-wildtype glioblastoma with histologically proven parotid, cervical lymph node, and lung metastases.
Jeroen Swinnen, MD, Geert Gelin, MD, Sabine Fransis, MD, Jan Vandevenne, MD, PhD, Sofie Van Cauter, MD, PhD   +4 more
doaj   +1 more source

In vitro evaluation of two controlled drug delivery systems to restore the anti-tumor activity of the immune system of glioblastoma patients

, 2022
reservedIl glioblastoma multiforme è uno dei tumori cerebrali più comunemente diagnosticati e aggressivi, caratterizzato da prognosi infausta e mancanza di approcci terapeutici efficaci.
MURARO, NORMA
core  

From Cell‐Derived Vesicles to Hybrid Nanovectors: Biological Membranes as Functional Blueprints for Gene Delivery

Advanced Healthcare Materials, EarlyView.
Biologically derived and hybrid nonviral nanovectors are examined as distinct but convergent design approaches. Integrating synthetic components with biologically functionalized membranes allows efficient interactions with complex cellular environments.
Clara Baldari, Claudia Leone, Gabriella Leccese, Claudia De Stradis, Alessandra Invidia, Concetta Quintarelli, Biagio De Angelis, Franco Locatelli, Giuseppe Gigli, Gabriele Maiorano, Ilaria Elena Palamà   +10 more
wiley   +1 more source

Genetics and epigenetics of glioblastoma: applications and overall incidence of IDH1 mutation

Frontiers in Oncology, 2016
Glioblastoma is the most fatal brain cancer found in humans. Patients suffering from glioblastoma have a dismal prognosis, with a median survival of 15 months. The tumor may develop rapidly de novo in older patients or through progression from anaplastic
Xuan eZong, Aizhen eLiu, Chunfeng eHou, Hongfang eChen, Xuan eZong, Peijun eZong   +5 more
doaj   +1 more source