Results 101 to 110 of about 81,769 (261)

Tumour Heterogeneity and Disease Infiltration as Paradigms of Glioblastoma Treatment Resistance [PDF]

Isocitrate dehydrogenase wild-type glioblastoma, a Grade 4 malignant brain neoplasm, remains resistant to multimodal treatment, with a median survival of 16 months from diagnosis with no geographical bias.
Pulkit Malhotra, Ruman Rahman, Malhotra, Pulkit, Rahman, Ruman   +3 more
core   +1 more source

The Price of Precision: A Critical Review of Molecular Diagnostics in Glioma, From Guidelines to Global Disparities

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Gliomas have undergone a profound redefinition over the past decade, transitioning from morphology‐based entities to biologically coherent diseases defined by molecular alterations. The 2021 WHO Classification of Tumors of the Central Nervous System and its 2022 update formalize this shift, establishing integrated diagnosis as the global ...
Maria Guarnaccia, Sebastiano Cavallaro
wiley   +1 more source

The molecular role of non-canonical Notch signaling via Deltex-1 in high grade glioma [PDF]

, 2011
Glioblastoma Multiforme is a WHO grade IV brain tumor with glial characteristics leading to more years of life lost than any other cancer. A better understanding of GBM biology and valid animal models are the two key elements to improved therapeutic ...
Huber, Roland Martin
core   +1 more source

Clinical Impact of MGMT Promoter Methylation in IDH‐Mutant Gliomas: Influence of Threshold Selection and Clinical Confounding

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background The clinical relevance of MGMT promoter methylation in IDH‐mutant gliomas remains controversial in the era of molecular classification. We aimed to systematically evaluate its clinical relevance by integrating quantitative assessment, cutoff exploration, and adjustment for clinical confounding.
Haihui Jiang, Linxi Cao, Xiaodong Chen, Siqi Tong, Qinghui Zhu, Jun Yang, Song Lin, Yong Cui   +7 more
wiley   +1 more source

Implantable Ionic Memristors Based on Natural Polymer Heterojunctions

Advanced Functional Materials, EarlyView.
We report an implantable natural polymer‐based ionic memristor composed of hyaluronic acid, chitosan, and PDMS. The device achieved 98.94% accuracy in MNIST classification while reducing training time by 36.8% compared with a conventional artificial neural network (ANN).
Dong‐yup Lee, Byung Ik Park, Gihyeon Yim, Hyunjae Yoo, Sangjun Ma, Jundong Park, Jeong‐Yun Sun   +6 more
wiley   +1 more source

Tectal glioblastoma Glioblastoma tetal

Arquivos de Neuro-Psiquiatria, 2007
Brain stem gliomas are a heterogeneous group of neoplasms arising mostly in paediatric patients. Tectal plate gliomas represent a particular type of brain stem tumours usually with a benign, indolent clinical course, presenting with signs of raised intracranial hipertension due to supra-tentorialhydrocephalous caused by aqueductal stenosis. Seldom high-
Feres Chaddad Neto, Armando Lopes, Mario Alberto Filho, Aguinaldo Catanoce, Andrei Fernandes Joaquim, Evandro de Oliveira   +5 more
openaire   +1 more source

Immunopathology of Glioblastoma

Annual Review of Pathology: Mechanisms of Disease
Glioblastoma (GBM), the most frequent and malignant primary brain tumor, is characterized by a highly diverse and profoundly immunosuppressive tumor microenvironment (TME) that provides an unconstrained environment for tumor progression and significantly complicates therapeutic interventions.
Jiabo, Li, James L, Ross, Dolores, Hambardzumyan, Daniel J, Brat   +3 more
openaire   +2 more sources

Nanotechnology-based cancer chemoprevention in glioblastoma

, 2023
Brain tumours are heterogeneous and are classified comprehensively into molecular subtypes based on genetic alterations. Glioblastoma rapid progression, drug resistance, and recurrence have been scientifically linked to several factors, including its ...
Gulnara Kapanova, Aima Adylova, Karlygash Raganina, Gulnur Tanbayeva, Zaure Datkhayeva, Kaini Baigonova   +5 more
core   +1 more source

3D Hydrodynamic Flow Lithography

Advanced Functional Materials, EarlyView.
ABSTRACT Continuous‐ and stop‐flow lithography are widely used to fabricate multi‐dimensional microstructures whose cross‐sectional morphology is dictated by the flow profile of multiple co‐flowing streams. Here, we introduce three‐dimensional hydrodynamic flow lithography (3D HFL), a platform for programmable generation of multi‐layered flow profiles ...
Yiying Zou, Mehmet Akif Sahin, Muhammad Zia Ullah Khan, Muhammad Usman Akhtar, Daniel Stoecklein, Ghulam Destgeer   +5 more
wiley   +1 more source

EphA3 CAR T cells are effective against glioblastoma in preclinical models

Journal for ImmunoTherapy of Cancer
Background Adoptive T-cell therapy targeting antigens expressed in glioblastoma has emerged as a potential therapeutic strategy to prevent or delay recurrence and prolong overall survival in this aggressive disease setting.
Xiang Li, Lea Lekieffre, Corey Smith, Rajiv Khanna, Fiona Smith, Paulo Martins, Bryan W Day, Rochelle C J D’Souza, Niclas Skarne, Shane Horsefield, Madusha Ranjankumar, Thuy T Le, Jacqueline Burrows   +12 more
doaj   +1 more source