Results 81 to 90 of about 258,291 (316)

The efficacy of the therapy of glioblastoma and future opportunities [PDF]

, 2018
A glioblastoma a leggyakoribb primer központi idegrendszeri malignitás felnőttekben. A kórismézésben bevezetésre került az integrált diagnózis fogalma, amely a tumor szövettani jellemzői mellett a molekuláris biológiai vizsgálatokat is figyelembe veszi ...
Tóth, Péter
core  

In vitro evaluation of two controlled drug delivery systems to restore the anti-tumor activity of the immune system of glioblastoma patients [PDF]

, 2022
reservedIl glioblastoma multiforme è uno dei tumori cerebrali più comunemente diagnosticati e aggressivi, caratterizzato da prognosi infausta e mancanza di approcci terapeutici efficaci.
MURARO, NORMA
core  

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Role of cytomegalovirus in glioblastoma development: promoter or culprit?

Virology Journal
Glioblastoma is the most common primary malignant tumor of the central nervous system, with a median survival of less than two years. While the etiology of glioblastoma is unclear, viral infection has emerged as a potential contributing factor ...
Xiaoxin Wu, Zhengyu Zhang, Liang Zhang, David J Daniels   +3 more
doaj   +1 more source

The translatome of glioblastoma

Molecular Oncology
Glioblastoma (GB), the most common and aggressive brain tumor, demonstrates intrinsic resistance to current therapies, resulting in poor clinical outcomes. Cancer progression can be partially attributed to the deregulation of protein translation mechanisms that drive cancer cell growth.
Fleur M. G. Cornelissen, Zhaoren He, Edward Ciputra, Richard R. de Haas, Ammarina Beumer‐Chuwonpad, David Noske, W. Peter Vandertop, Sander R. Piersma, Connie R. Jiménez, Cornelis Murre, Bart A. Westerman   +10 more
openaire   +3 more sources

From tumor‐centric to ecosystem‐based hypotheses in brain tumor research and care

Molecular Oncology, EarlyView.
Primary brain tumors, whether in adults or children, present a major challenge because of their dramatic prognosis and the ongoing lack of efficient therapeutic approaches. In recent years, a shift has occurred from tumor‐centric concepts to a more holistic view of these tumors as dynamic ecosystems.
Julie Gavard, Flavie Bénard, Eva Billat, Margaux Le Guyon, Victoria Maltret, Laura Merlet, Chloé Astrid Walter, Tony Avril, Eric Chevet   +8 more
wiley   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Rhabdoid Glioblastoma: An Aggressive Variety of Astrocytic Tumor [PDF]

, 2015
2015-02Rhabdoid glioblastoma (RGBM) is rare, but the most malignant among astrocytic tumors. Accumulating evidence indicates its highly aggressive nature and distinct histopathological features.
TAKAHASHI, AKIRA, HASEGAWA, TADASHI, MOMOTA, HIROYUKI, OGINO, JIRO, WAKABAYASHI, TOSHIHIKO   +4 more
core   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

New advances in the treatment of glioblastoma [PDF]

, 2019
Glioblastoma (GB) is a refractory malignancy with limited treatment option. Despite current standard of care, GB still has a dismal prognosis. Although GBs are highly malignant and incurable, significant advances in the understanding of the molecular ...
Yi-Ning, Li
core