Results 71 to 80 of about 81,769 (261)
Arquivos de Neuro-Psiquiatria, 2007 Brain stem gliomas are a heterogeneous group of neoplasms arising mostly in paediatric patients. Tectal plate gliomas represent a particular type of brain stem tumours usually with a benign, indolent clinical course, presenting with signs of raised intracranial hipertension due to supra-tentorialhydrocephalous caused by aqueductal stenosis. Seldom high-
Chaddad Neto, Feres +5 more
openaire +4 more sources
, 2023 reservedIl glioblastoma o glioblastoma multiforme (GBM) è il cancro cerebrale primario più comune ed aggressivo negli adulti. Nonostante le tecniche di trattamento multimodale, come la resezione chirurgica, la radioterapia e la chemioterapia con l ...
TESSARI, JESSICA
core
Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
A novel circular RNA circENTPD7 contributes to glioblastoma progression by targeting ROS1
Cancer Cell International, 2020 Background Circular RNAs (circRNAs) are identified to play an important role in many human cancers, such as glioblastoma. However, the potential mechanisms underlying the relationship between circRNAs and glioblastoma pathogenesis are still elusive. This
Fei Zhu +4 more
doaj +1 more source
Journal of Translational Medicine, 2021 Background Epidermal growth factor receptor (EGFR) and lanthionine synthetase C-like 2 (LanCL2) genes locate in the same amplicon, and co-amplification of EGFR and LANCL2 is frequent in glioblastoma.
Hua-fu Zhao +14 more
doaj +1 more source
Role of lncRNA expression in glioblastoma
, 2021 Glioblastoma (GBM) is amongst the most frequently identified malignant brain tumors, it has a high mortality rate and a poor prognosis. The overall survival rate remains poor despite the multimodal therapies including acute resection, radiotherapy and ...
Erdenesanaa, Angiraa
core
Molecular Oncology, EarlyView.This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu +3 more
wiley +1 more source
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
Rhabdoid Glioblastoma: An Aggressive Variety of Astrocytic Tumor [PDF]
, 2015 2015-02Rhabdoid glioblastoma (RGBM) is rare, but the most malignant among astrocytic tumors. Accumulating evidence indicates its highly aggressive nature and distinct histopathological features.
TAKAHASHI, AKIRA +4 more
core +1 more source
Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk
Molecular Oncology, EarlyView.Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley +1 more source