Results 171 to 180 of about 358,441 (297)

AI‐Driven Cancer Multi‐Omics: A Review From the Data Pipeline Perspective

Advanced Intelligent Discovery, EarlyView.
The exponential growth of cancer multi‐omics data brings opportunities and challenges for precision oncology. This review systematically examines AI's role in addressing these challenges, covering generative models, integration architectures, Explainable AI for clinical trust, clinical applications, and key directions for clinical translation.
Shilong Liu, Shunxiang Li, Kun Qian
wiley   +1 more source

Stimuli‐Responsive Silsesquioxane Nanozymes for Organocatalysis in Water and Prodrug Activation in Cells

Angewandte Chemie, EarlyView.
Amino‐bearing silsesquioxanes are water‐stable nanozymes that exhibit aggregation‐ and disaggregation‐dependent catalysis and can be applied to intracellular prodrug activation for cancer therapy. ABSTRACT Synthetic nanozymes have emerged as promising alternatives to natural enzymes for catalytic and therapeutic applications, yet their limited ...
Rabia Zahid, Ariadna Lázaro, Guillermo Moreno‐Alcántar, María Sancho‐Albero, Pierre Picchetti   +4 more
wiley   +2 more sources

Basal ganglia glioblastoma with lung adenocarcinoma tumor-to-tumor metastasis and atypical early imaging presentation: illustrative case. [PDF]

J Neurosurg Case Lessons
Badra R, Ravina K, Emanuel AJ, Cuoco JA, Marvin EA, Rogers CM.   +5 more
europepmc   +1 more source

KDLM: Lightweight Brain Tumor Segmentation via Knowledge Distillation

Advanced Intelligent Systems, EarlyView.
A lightweight student network is designed, which is based on multiscale and multilevel feature fusion and combined with the residual channel attention mechanism to achieve efficient feature extraction and fusion with very few parameters. A dual‐teacher collaborative knowledge distillation framework is proposed.
Baotian Li, Haoyu Tang, Jun Zhu, Fang Fang Gou, Jia Wu   +4 more
wiley   +1 more source

Circulating EV miRNA Cargo in Glioblastoma Patients Is Associated with Distinct Gene Expression Signatures in Peripheral Immune Cells, Suggesting an Early, Compartment-Specific Immune Priming State. [PDF]

Biomedicines
Popovic-Vukovic M, Kolic I, Stankovic A, Zivkovic M, Milicevic M, Bogdanovic I, Srbljak I, Petrovic N, Stanojkovic T, Nikitovic M, Jovanovic I.   +10 more
europepmc   +1 more source

Therapeutic Applications of Stimuli‐Based Release and Engineering of Extracellular Vesicles

Advanced NanoBiomed Research, EarlyView.
This review summarizes the effects of endogenous and exogenous stimuli, their effects on the natural release of extracellular vesicles, as well as their uptake and release. It also gives an overview of stimuli‐responsive EVs and their therapeutic applications. Extracellular vesicles (EVs), nano‐ to microsized lipid bilayer membrane‐bound particles, are
Gloria Kemunto, Kristen Dellinger
wiley   +1 more source

Glioblastoma and PARP inhibitors: the importance of patient selection to maximize therapeutic benefits. A critical review. [PDF]

Front Oncol
Dima G, Di Nunno V, Aprile M, Gatto L, Tosoni A, Argento CM, Margotti M, Bartolini S, Franceschi E.   +8 more
europepmc   +1 more source

Nonviral Gold Nanoparticle‐Mediated Delivery of CRISPR‐Cas9 Ribonucleoprotein and Long DNA Transgenes Into Primary Blood Cells

Advanced NanoBiomed Research, EarlyView.
CRISPR/Cas9 has revolutionized the field of gene therapy, but delivery remains an outstanding issue. We propose a nonviral gold‐nanoparticle platform for co‐delivery of CRISPR/Cas9 ribonucleoprotein and long 2.1 kilobase dsDNA transgene constructs. This CRISPR‐AuNP is inexpensive to produce and mediate gene editing and DNA delivery in T cells and CD34+
Rachel A. Cunningham, Karthikeya S. V. Gottimukkala, Daniel D. Lane, Katrina Poljakov, Patricia Lipson, Mark R. Enstrom, Alessandro Rizzi, Aude G. Chapuis, Jennifer E. Adair   +8 more
wiley   +1 more source

Molecularly distinct collision tumor consisting of meningothelial meningioma and glioblastoma, IDH-wildtype: illustrative case. [PDF]

J Neurosurg Case Lessons
Ueno A, Tsukamoto Y, Sakai K, Takahashi A, Saito T, Nozawa T, Shibuma S, Shibuya K, Nakayama Y, Shimizu H, Okamoto K, Natsumeda M, Kakita A, Oishi M.   +13 more
europepmc   +1 more source

Heterogenous Model of Temozolomide Resistance in Glioblastoma Reveals Phenotypic Shifts in Drug Response and Migratory Potential

Advanced NanoBiomed Research, EarlyView.
Glioblastoma mortality is driven by cell invasion and therapeutic resistance. We report a cancer engineering approach to evaluate the behavior of heterogeneous cohorts of temozolomide resistant and responsive GBM cells. We show the effect of physiologically‐relevant metronomic dosing on ensemble drug response and invasion.
Victoria A. Kriuchkovskaia, Ela K. Eames, Sydney A. McKee, Paul J. Hergenrother, Rebecca B. Riggins, Brendan A. C. Harley   +5 more
wiley   +1 more source