Results 171 to 180 of about 81,769 (261)
F7 Drives Gastric Cancer Metastasis Through Anoikis Resistance and Tumor Microenvironment Remodeling
Advanced Science, EarlyView.ABSTRACT Coagulation factor VII (F7) has been implicated in tumor progression; however, its role in gastric cancer metastasis and immune evasion remains incompletely understood. In this study, we identified F7 as a clinically relevant driver of gastric cancer.
Lei Gao +9 more
wiley +1 more source
Design of a Drug Delivery System for the Localized Treatment of Resected Glioblastoma
reservedDesign of a Drug Delivery System for the Localized Treatment of Resected Glioblastoma Glioblastoma (GBM), a grade 4 glioma, is the most common primary malignant brain tumor in adults..
CAMDZIC, JELENA
core
Immunohistochemiczna metoda identyfikacji komórek CD133+ w glioblastoma
, 2013 Najczęstszym i jednocześnie najgorzej rokującym nowotworem pochodzenia astrocytarnego jest glioblastoma (IV stopień złośliwości według Światowej Organizacji Zdrowia).
Emil Zielonka
core
Advanced Science, EarlyView.Lactate accumulation in glioblastoma drives lactylation of STING at lysine 370, a primate‐conserved residue. K370 lactylation weakens STING‐TBK1 binding, destabilizes STING, and disrupts ER‐to‐Golgi trafficking, blunting type I interferon signaling. LDHA inhibition reverses K370 lactylation and improves the antitumor efficacy of STING agonism combined ...
Yueyao Wu +11 more
wiley +1 more source
Análisis de enriquecimiento de genes asociados a la heterogeneidad en Glioblastoma Multiforme
El Glioblastoma Multiforme (GBM) es un tumor cerebral agresivo y común en adultos, caracterizado por su heterogeneidad genómica y mal pronóstico, con una supervivencia media de aproximadamente un año tras el diagnóstico.
Balvoa Caguana, Susana Isabel
core +1 more source
Supramolecular Degraders: An Emerging Paradigm in Targeted Protein Degradation
Advanced Science, EarlyView.Dynamic supramolecular assembly reshapes targeted protein degradation by coordinating modular degrader construction, delivery, functional integration, and intracellular assembly or activation across proteasomal, endosomal–lysosomal, and autophagy–lysosomal pathways.
Kongjun Liu +8 more
wiley +1 more source
Advanced Science, EarlyView.SLC8A1 deficiency in colorectal cancer cells increases intracellular calcium signaling, promoting the secretion of ANXA2‐enriched small extracellular vesicles. These vesicles reprogram tumor‐associated macrophages towards an M2 phenotype, which in turn fosters a tumor microenvironment conducive to radioresistance and is associated with poor patient ...
Yimin Fang +18 more
wiley +1 more source
A Cascaded DNA Nanocircuit for Multi‐Signal‐Responsive Precision siRNA Delivery in Cancer Therapy
Advanced Science, EarlyView.A cascaded dual‐AND logic DNA nanocircuit is engineered to respond to three tumor‐specific signals in a sequential manner: extracellular acidic pH, membrane‐overexpressed nucleolin (NCL), and intracellular glutathione (GSH). This programmable system selectively releases siPARP1 in glioblastoma (GBM), effectively silencing PARP1 and reversing TMZ ...
Yan Zhao +14 more
wiley +1 more source
The multiforme of glioblastoma [PDF]
Neuro-Oncology, 2018 Farshad, Nassiri +2 more
openaire +2 more sources
Advanced Science, EarlyView.In this study, we identify a novel functional role of ZBTB18 in regulating trigeminal‐mediated neuropathic pain. Nerve injury reduces ZBTB18 in trigeminal ganglion neurons, impairing CHD4/NuRD recruitment and de‐repressing Clic1. Elevated CLIC1 enhances chloride channel activity and neuronal hyperexcitability, thereby driving pain.
Shoupeng Wang +11 more
wiley +1 more source