Results 181 to 190 of about 319,103 (346)

The TET3/GATA6 Axis Drives Lipid Metabolism and Therapeutic Vulnerabilities in Pancreatic Ductal Adenocarcinoma

Advanced Science, EarlyView.
The DNA demethylase TET3 drives lipid metabolic reprogramming in pancreatic ductal adenocarcinoma via a non‐catalytic mechanism. TET3 recruits histone deacetylases to repress GATA6, sustaining lipogenic enzyme expression and ferroptosis resistance.
Shuai Liu, Shaobo Kang, Na Lin, Wenqi Zhang, Shiwen Wang, Yuqing Ren, Xiaofan Ding, Jianxiu Yu, Ruiyu Xie   +8 more
wiley   +1 more source

Pharmacokinetics and Tolerance of Nicotinamide Combined with Radiation Therapy in Patients with Glioblastoma Multiforme [PDF]

, 1994
F. Cartei, Romano Danesi, Francesco Ducci, L. Fatigante, Pier G. Caciagli, Mario Del Tacca, M Laddaga   +6 more
openalex   +1 more source

Bispecific Antibody Targeting VEGF/TGF‐β Synergizes with Local Radiotherapy: Turning Tumors from Cold to Inflamed and Amplifying Abscopal Effects

Advanced Science, EarlyView.
Y332D, a bispecific antibody that simultaneously blockades VEGF and TGF‐β, counteracted negative RT effects that are attributed to the upregulation of TGF‐β and VEGF, as well as further enhanced the immunostimulatory effects of RT, thereby reprograming the TME from immune “cold” to inflamed state and forming an effective in‐situ vaccine that eradicate ...
Lijuan Lyu, Ming Yi, Ji Chen, Jing Zhang, Xiaobin Ma, Xiaojun Zhang, Liang Zeng, Yan Xue, Haimei Wen, Yujiao Deng, Pengfei Zhou, Kongming Wu, Huafeng Kang, Zhijun Dai   +13 more
wiley   +1 more source

Investigating the correlation between tea intake and glioblastoma: A Mendelian randomization study. [PDF]

Medicine (Baltimore)
Zhang C, Wang S, Shi D, Zhao W.
europepmc   +1 more source

Radiation Exposure Induced Blood–Brain Barrier Injury via Mitochondria‐Mediated Sterile Inflammation

Advanced Science, EarlyView.
This work describes a blood–brain barrier (BBB) microphysiological system (MPS) to explore the responses of BBB to radiation exposure. Following radiation exposure, obvious BBB comprise and brain endothelial injuries are detected. Mechanism study shows radiation induced significant sterile inflammation via mitochondrial dysfunction and cGAS‐STING ...
Peng Wang, Jiayue Liu, Min Zhang, Juan Yang, Peihan Lian, Xiu Cheng, Jianhua Qin   +6 more
wiley   +1 more source

Graphene Quantum Dots for Glioblastoma Treatment and Detection-Systematic Review. [PDF]

Molecules
Kregielewski K, Fraczek W, Grodzik M.
europepmc   +1 more source

Activation of expression of genes coding for extracellular matrix proteins in Tat-producing glioblastoma cells. [PDF]

, 1992
J. Paul Taylor, Crystina Cupp, Arturo Díaz, M Chowdhury, Kamel Khalili, Sergio A. Jiménez, Shohreh Amini   +6 more
openalex   +1 more source

What is a glioblastoma?

Neuro-Oncology, 2023
Andrew B Lassman, Martin J van den Bent
openaire   +3 more sources

Combining PIM‐2 and PARP1 Inhibitors Induces MICA Expression on Multiple Myeloma Cells to Activate NK Cells through NKG2D Binding

Advanced Science, EarlyView.
The findings suggest that the combination of PIM‐2 and PARP1 inhibitors can induce MICA expression on MM cells, thereby activating NK cells through NKG2D binding. This process may restore NK cell function and serve as a potential therapeutic approach for MM patients. Abstract While immunogenic death in tumor cells activates specific anti‐tumor T cells,
Zhaoyun Liu, Wenhui Lei, Xiaohan Liu, Hui Liu, Kai Ding, Jia Song, Rong Fu   +6 more
wiley   +1 more source

Molecular targets of vortioxetine mediating glioblastoma suppression revealed by gene and protein network analyses and molecular docking simulations. [PDF]

Int J Neuropsychopharmacol
Zhuo C, Li C, Zhang Q, Yang L, Zhang Y, Chen X, Ma X, Li R, Wang L, Tian H.   +9 more
europepmc   +1 more source