Results 261 to 270 of about 437,642 (362)

Precision therapies for genetic epilepsies in 2025: Promises and pitfalls

Epilepsia Open, EarlyView.
Abstract By targeting the underlying etiology, precision therapies offer an exciting paradigm shift to improve the stagnant outcomes of drug‐resistant epilepsies, including developmental and epileptic encephalopathies. Unlike conventional antiseizure medications (ASMs) which only treat the symptoms (seizures) but have no effect on the underlying ...
Shuyu Wang, Emilio Perucca, Samuel F. Berkovic, Piero Perucca   +3 more
wiley   +1 more source

Enterohepatic recirculation model of irinotecan (CPT-11) and metabolite pharmacokinetics in patients with glioma

, 2008
Islam R. Younis, Samuel A. Malone, Henry S. Friedman, Larry J. Schaaf, William P. Petros   +4 more
openalex   +2 more sources

NOD1/RIP2 Pathway Promotes Glioma Progression Through Microglial M2 Polarization. [PDF]

CNS Neurosci Ther
Luan Y, Yu M, Zhang H, Zhang X, Xiao P, Zhou F, Zhao T, Wang X, Wang X.   +8 more
europepmc   +1 more source

Targeting MGAT4A‐Mediated N‐Glycosylation as a Therapeutic Strategy to Inhibit Glioblastoma Stem Cell Invasion

Exploration, EarlyView.
ABSTRACT Glioblastoma (GBM) is the most aggressive type of primary brain tumor, and its invasive properties contribute significantly to incomplete surgical resection and tumor recurrence. Despite extensive clinical efforts to mitigate GBM invasion, targeted therapies against GBM stem cells (GSCs), which drive invasion, remain incompletely understood ...
Rui Niu, Meichen Liu, Qingshan Yang, Jinlong Yin   +3 more
wiley   +1 more source

Glycoprotein M6B suppresses the maintenance of glioma stem cell stemness and proliferation via the integrin β1/β-catenin pathway. [PDF]

Front Mol Biosci
Chen Y, Fan Y, Run X, Liu M, Jiang S, Miao Z, Tian W.   +6 more
europepmc   +1 more source

Gliomas: da epidemiologia ao tratamento

, 2012
Barbosa
openalex   +1 more source

Advanced extracellular vesicle immunotherapy

FlexMat, EarlyView.
A diagrammatic depiction of the therapeutic applicability of extracellular vesicles (EVs) in immunotherapy. This review explores the dual roles of tumor‐derived and immune cell‐derived EVs in cancer immunotherapy, discusses recent progress in EV engineering that improve their clinical utility, and evaluates their potential to augment existing ...
Jingjing Zhang, Yunfei Mu, Xianyue Ji, Xiaoting Jiang, Ruiheng Wang, Xianguang Ding, Lianhui Wang   +6 more
wiley   +1 more source

Recent advances in immunotherapy for gliomas: overcoming barriers and advancing precision strategies. [PDF]

Front Immunol
Jabri A, Mhannayeh A, Taftafa B, Alsharif M, Sibai D, Alsharif R, Abbad T, Elsalti A, Ahmed Z, Salma J, Khan MI, Yaqinuddin A.   +11 more
europepmc   +1 more source

Chloride Intracellular Channel 2 Can Function as a Malignant Factor in Head and Neck Squamous Cell Carcinoma

Head &Neck, EarlyView.
ABSTRACT Background The association of chloride intracellular channel 2 (CLIC2) with tumors has remained unclear. However, recently, CLIC2 was found to exhibit antitumor properties in some tumors. In this study, we aimed to evaluate the clinical relevance of CLIC2 expression in head and neck squamous cell carcinoma (HNSCC) to determine whether it ...
Yuki Hosokawa, Shoko Miyoshi, Yuji Hayashi, Yuki Irifune, Eriko Sato, Sohei Mitani, Mohammed Choudhury, Hajime Yano, Junya Tanaka, Naohito Hato   +9 more
wiley   +1 more source

A single-cell atlas of RNA alternative splicing in the glioma-immune ecosystem. [PDF]

Genome Biol
Song X, Tiek D, Lu M, Yu X, Wu R, Walker M, He Q, Sisbarro D, Hu B, Cheng SY.   +9 more
europepmc   +1 more source