Results 281 to 290 of about 382,034 (365)

Molecular Tumor Boards in Malignant Melanoma: Uncovering Challenges and Opportunities in a Bicenter Retrospective Analysis in Germany

International Journal of Cancer, EarlyView.
Molecular tumor boards (MTB), interdisciplinary teams that use tumor genomic data to guide personalized treatment decisions, have emerged as a promising strategy in melanoma care, although their real‐world clinical impact remains uncertain. This retrospective study evaluated advanced melanoma patients to assess molecularly guided treatment ...
Glenn Geidel, Theresa Lowinus, Patrick Metzger, Rebecca Czurda, Vincent Schipperges, Ulrike Paul, Alessandra Rünger, Julian Kött, Isabel Heidrich, Saskia Lehr, Julia Kühn, Heiko Becker, Cornelius Miething, Martin Werner, Silke Laßmann, Justus Duyster, Tilman Brummer, Ronald Simon, Winfried Alsdorf, Maximilian Christopeit, Carsten Bokemeyer, Kilian Eyerich, Stefan W. Schneider, David Rafei, Melanie Börries, Frank Meiss, Christoffer Gebhardt   +26 more
wiley   +1 more source

Beyond synapses non-synaptic neural microenvironment interactions remodel circuits and drive glioma progression. [PDF]

Front Oncol
Zhang S, Wang H, Wang B, Chi N, He Q, Sun Y, Zhang H.   +6 more
europepmc   +1 more source

Closing the Loop in Precision Oncology: A Digital Twin‐Driven Paradigm for Dynamic Decision‐Making

iMetaMed, EarlyView.
This review introduces the Closed‐Loop Intelligent Oncology System (CIOS), a five‐layer framework integrating digital twins and AI to enable adaptive, data‐driven cancer treatment. By synthesizing advances in multimodal perception, mechanistic simulation, and safe reinforcement learning, CIOS charts a roadmap toward dynamic, personalized oncology ...
Junye Zhu, Mengqi Yang, Chenxi Ouyang, Lin Zhang   +3 more
wiley   +1 more source

Targeting the tumor microenvironment: reprogramming macrophages as a novel therapeutic strategy in FUOM-deficient glioblastoma. [PDF]

Cell Death Dis
Lu B, Xu M, Zhang H, Zhang X, Sun P, Yang L, Shi J, Huang J.   +7 more
europepmc   +1 more source

Hypervision Proton Surgery: The Future Direction of Proton Therapy

iNew Medicine, EarlyView.
ABSTRACT Proton beams provide unique physical advantages characterized by a low entrance dose, negligible exit dose, and a sharp Bragg peak, which enable superior sparing of normal tissues and support safe dose escalation for improved tumor control. However, conventional photon‐based fractionation remains widely used in proton therapy, where prolonged ...
Li Li, Shuanghu Yuan
wiley   +1 more source

ASLNet: an explainable deep learning framework for glioma grading and survival prediction. [PDF]

Front Oncol
Christodoulou RC, Vamvouras G, Papageorgiou PS, Vassiliou E, Papageorgiou SG, Kalogeropoulou C, Zampakis P, Solomou EE, Georgiou MF.   +8 more
europepmc   +1 more source

Implantable drug delivery system: Frontiers of medicine‐engineering interdisciplinary

Interdisciplinary Medicine, EarlyView.
This review systematically summarizes the driving mechanisms of implantable on‐demand drug delivery systems (IDDS), including endogenous, exogenous, and closed‐loop strategies. It highlights the pivotal roles of flexible electronics and miniaturization in enhancing the tissue conformity and spatial adaptability.
Yu Zeng, Rongtai Su, Manyu Zhao, Xin Song, Ran Liu, Yuhao Zhou, Chaojuan Yang, Yanli Jiao, Xiao‐Wei Xiang, Lingqian Chang   +9 more
wiley   +1 more source

<i>DLG2</i>-<i>DLG4</i> Expression Is Associated with Improved Survival and a Synaptic Gene Signature in Lower-Grade Glioma. [PDF]

Cancers (Basel)
Gaia F, Dal-Pizzol HR, Malafaia O, Roesler R, Isolan GR.   +4 more
europepmc   +1 more source

A compendium of extracellular vesicle biogenesis inhibitors: From bench to bedside

Interdisciplinary Medicine, EarlyView.
This review explores a decade of research on extracellular vesicles (EVs), detailing their biogenesis and roles in health and disease. It emphasizes EVs' relevance for potential medical applications covering various conditions such as cancer, neurodegeneration, inflammation, and infectious diseases, bridging experimental findings with clinical ...
Stefano Vecchione, Ana Talamillo, Juan M. Falcón‐Pérez   +2 more
wiley   +1 more source

Cross-species transcriptomic integration reveals a MIRO1-mediated macrophage-T cell axis in glioma. [PDF]

Life Sci Alliance
Du Z, Li M, Bergsneider BH, Tsai AP, Cho KB, Kim LH, Choi J, Li G, Wyss-Coray T, Lim M, Wang X.   +10 more
europepmc   +1 more source