Results 241 to 250 of about 1,750,541 (324)

Cross‐Modal Denoising and Integration of Spatial Multi‐Omics Data with CANDIES

Advanced Science, EarlyView.
In this paper, we introduce CANDIES, which leverages a conditional diffusion model and contrastive learning to effectively denoise and integrate spatial multi‐omics data. We conduct extensive evaluations on diverse synthetic and real datasets, CANDIES shows superior performance on various downstream tasks, including denoising, spatial domain ...
Ye Liu, Wanpeng Zou, Yuekai Li, Jiayi Wang, Mingxuan Cai, Hongmin Cai   +5 more
wiley   +1 more source

Efficacy of dolutegravir-based therapy in achieving virological suppression in PLHIV in low- and middle-income countries: real-world evidence from a large clinical cohort in Cameroon. [PDF]

BMC Infect Dis
Tadenfok C, Fokam J, Semengue ENJ, Mossiang L, Oyie S, Noumo P, Ngia J, Beloumou GA, Djupsa Ndjeyep SC, Nka AD, Chenwi Ambe C, Ka'e AC, Takou D, Ngwese DTA, Anim-Keng TT, Forgwei L, Kengne A, Yagai B, Elong Lobe E, Feukeng A, Awoh RA, Bissek AZ, Vouking M, Ndjolo A, Ndembi N, Perno CF, Kouanfack C, Nkenfou C.   +27 more
europepmc   +1 more source

INB3P: A Multi‐Modal and Interpretable Co‐Attention Framework Integrating Property‐Aware Explanations and Memory‐Bank Contrastive Fusion for Blood–Brain Barrier Penetrating Peptide Discovery

Advanced Science, EarlyView.
INB3P is a multimodal framework for blood–brain barrier‐penetrating peptide prediction under extreme data scarcity and class imbalance. By combining physicochemical‐guided augmentation, sequence–structure co‐attention, and imbalance‐aware optimization, it improves predictive performance and interpretability.
Jingwei Lv, Qianyang Wu, Jian Liu, Binlu Yang, Yuanhao Li, Junlin Xu, Yajie Meng, Leyi Wei, Zilong Zhang, Quan Zou, Xiulai Li, Feifei Cui   +11 more
wiley   +1 more source

Importance of Humanities and Compassionate Care in the Age of Artificial Intelligence. [PDF]

JNMA J Nepal Med Assoc
Subedi M.
europepmc   +1 more source

Ethical Precision in Nanoscale Brain Interfacing

Advanced Science, EarlyView.
As brain interfaces approach the nanoscale, precision no longer only measures—it knows, predicts, and potentially reshapes the mind. This work argues that traditional ethics fails under such conditions and proposes a shift toward continuous, operation‐based governance using the recovery–discovery framework to track, constrain, and responsibly steer ...
Guilherme Wood
wiley   +1 more source

Characterizing multimorbidity and the risk for hospitalization among people living with HIV from the African Cohort Study. [PDF]

BMC Glob Public Health
Scott R, Olsen CH, Crowell TA, Mancuso JD, Kibuuka H, Maswai J, Owuoth J, Sing'oei V, Bahemana E, Parker Z, Ake JA, Shah N, Lee EH.   +12 more
europepmc   +1 more source

Discovering Interpretable Semantics from Radio Signals for Contactless Cardiac Monitoring

Advanced Science, EarlyView.
This study presents a semantic representation framework for clinically interpretable cardiac monitoring from contactless radio signals. It formulates radio semantic learning as an information‐bottleneck problem and approximates the objective via intra‐modal compression and cross‐modal alignment, structuring radio measurements into meaningful semantic ...
Jinbo Chen, Haoyu Wang, Guixin Xu, Yuqin Yuan, Xinmeng Cai, Zhengwu Wei, Dongheng Zhang, Qibin Sun, Tianwei Zhang, Cuntai Guan, Yan Chen   +10 more
wiley   +1 more source

Long-Acting Injectable HIV Therapy Outcomes Among Persons With HIV Who Have Adherence Challenges to Oral Antiretroviral Therapy. [PDF]

Clin Infect Dis
Hastie E, Hill L, Bamford L, Karim A, Martin TCS.   +4 more
europepmc   +1 more source

Approaches to the Management of Virologic Failure on Dolutegravir-Based Antiretroviral Therapy in the 50 Countries With the Highest Adult HIV Prevalence. [PDF]

Clin Infect Dis
Nutt CT, Lessells RJ, Muyindike WR, Johnson LS, Kouyos RD, Loosli T, Ombajo LA, Brijkumar J, Hyle EP, Moosa MS, Gandhi M, Vitoria MAA, Jordan MR, Siedner MJ, McCluskey SM.   +14 more
europepmc   +1 more source