Results 41 to 50 of about 8,017 (310)

Cyclic nucleotide signaling as a drug target in retinitis pigmentosa

FEBS Letters, EarlyView.
Disruptions in cGMP and cAMP signaling can contribute to retinal dysfunction and photoreceptor loss in retinitis pigmentosa. This perspective examines the mechanisms and evaluates emerging evidence on targeting these pathways as a potential therapeutic strategy to slow or prevent retinal degeneration.
Katri Vainionpää, Ahmed B. Montaser, Henri Leinonen   +2 more
wiley   +1 more source

On Global Attractors for a Class of Reaction-Diffusion Equations on Unbounded Domains with Some Strongly Nonlinear Weighted Term

Discrete Dynamics in Nature and Society, 2015
We consider the existence and properties of the global attractor for a class of reaction-diffusion equation ∂u/∂t-Δu-u+κ(x)|u|p-2u+f(u)=0,  in  Rn×R+;  u(x,0)=u0(x),  in  Rn.
Jin Zhang, Chengkui Zhong
doaj   +1 more source

Dynamic of the nonclassical diffusion equation with memory

Boundary Value Problems, 2023
In this paper, we consider the nonclassical diffusion equation with memory and the nonlinearity of the polynomial growth condition of arbitrary order in the time-dependent space.
Jing Wang, Qiaozhen Ma, Wenxue Zhou, Xiaobin Yao   +3 more
doaj   +1 more source

Pointed shape and global attractors for metrizable spaces [PDF]

Topology and its Applications, 2011
In this paper we consider two notions of attractors for semidynamical systems de ned in metric spaces. We show that Borsuk's weak and strong shape theories are a convenient framework to study the global properties which the attractor inherits from the phase space.
Romero Ruiz Del Portal, Francisco, Giraldo, A., Jiménez, R., Alonso Morón, Manuel, Rodríguez Sanjurjo, José Manuel   +4 more
openaire   +3 more sources

Cell‐free DNA aneuploidy score as a dynamic early response marker in prostate cancer

Molecular Oncology, EarlyView.
mFast‐SeqS‐based genome‐wide aneuploidy scores are concordant with aneuploidy scores obtained by whole genome sequencing from tumor tissue and can predict response to ARSI treatment at baseline and, at an early time point, to ARSI and taxanes. This assay can be easily performed at low cost and requires little input of cfDNA. Cell‐free circulating tumor
Khrystany T. Isebia, Anouk C. de Jong, Lisanne F. van Dessel, Vanja de Weerd, Corine Beaufort, Jean Helmijr, José Alberto Nakauma‐González, Job van Riet, Paul Hamberg, Daniel Vis, Michiel S. van der Heijden, Nick Beije, Martijn P. Lolkema, Teoman Deger, Saskia M. Wilting, Ronald de Wit, Maurice P. H. M. Jansen, John W. M. Martens   +17 more
wiley   +1 more source

MET variants with activating N‐lobe mutations identified in hereditary papillary renal cell carcinomas still require ligand stimulation

Molecular Oncology, EarlyView.
MET variants in the N‐lobe of the kinase domain, found in hereditary papillary renal cell carcinoma, require ligand stimulation to promote cell transformation, in contrast to other RTK variants. This suggests that HGF expression in the microenvironment is important for tumor growth in such patients. Their sensitivity to MET inhibitors opens the way for
Célia Guérin, Audrey Vinchent, Marie Fernandes, Isabelle Damour, Agathe Laratte, Rémi Tellier, Gabriella O. Estevam, Jean‐Pascal Meneboo, Céline Villenet, Clotilde Descarpentries, James S. Fraser, Martin Figeac, Alexis B. Cortot, Etienne Rouleau, David Tulasne   +14 more
wiley   +1 more source

Stability of limit regimes in general reaction-diffusion type systems

Науковий вісник Ужгородського університету. Серія: Математика і інформатика, 2022
In this paper, we consider the stability of limit regimes for a general class of nonlinear distributed mathematical models named Reaction-Diffusion models. RD systems naturally arise in many applications.
О. В. Капустян, Т. В. Юсипів   +1 more
doaj   +1 more source

Global Attractor for Sectorial Evolutionary Equation

Journal of Differential Equations, 1996
AbstractAn abstract differential equation with sectorial operator is shown to generate a dissipative semigroup whenever an appropriate introductory estimate for solutions is known. Based on Hale's theory ofdissipative systemssuch ana prioriestimate is then shown to be sufficient for existence of a global attractor.
Tomasz Dlotko, Jan W. Cholewa
openaire   +2 more sources

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

Molecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes, Mario Ortega Duran, Solon Karapanagiotis, Alistair Martin, Meiling Gao, Riccardo Masina, Ramona Woitek, James Tanner, Fleur Tippin, Justine Kane, Jonathan Lay, Anja Brouwer, Stephen‐John Sammut, Suet‐Feung Chin, Davina Gale, Dana W. Y. Tsui, Sarah‐Jane Dawson, Nitzan Rosenfeld, Maurizio Callari, Oscar M. Rueda, Carlos Caldas   +20 more
wiley   +1 more source

Global Attractors and Asymptotic Gain Property for Non-Autonomous Inclusion of Reaction–Diffusion Type

Journal of Optimization, Differential Equations and Their Applications
We investigate global resolvability and stability of attractors for parabolic inclusion with multi-valued interaction function of reaction-diffusion type and non-autonomous disturbances.
Oleksiy V. Kapustyan, Taras V. Yusypiv, M. Ospanov, M. Alday   +3 more
doaj   +1 more source