Results 61 to 70 of about 6,795 (265)
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Simplicial Models for the Global Dynamics of Attractors
Journal of Differential Equations, 2000 The author considers a flow \(\phi\) on a compact metric space \(\mathcal{A}\) which has a Morse decomposition \(\{S_p\}_{p\in P}\) indexed by the partially ordered set \((P,
openaire +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source
Time-Dependent Global Attractor for a Class of Nonclassical Parabolic Equations
Journal of Applied Mathematics, 2014 Based on the recent theory of time-dependent global attractors in the works of Conti et al. (2013) and di Plinio et al. (2011), we prove the existence of time-dependent global attractors as well as the regularity of the time-dependent global attractor ...
Fang-hong Zhang
doaj +1 more source
Global dynamics of a fourth-order parabolic equation describing crystal surface growth
Nonlinear Analysis, 2019 In this paper, we study the global dynamics for the solution semiflow of a fourth-order parabolic equation describing crystal surface growth. We show that the equation has a global attractor in H4per(Ω) when the initial value belongs to H1per(Ω).
Ning Duan, Xianyun Xu
doaj +1 more source
Viral Infection Model with Diffusion and Distributed Delay: Finite-Dimensional Global Attractor. [PDF]
Qual Theory Dyn Syst, 2023 Rezounenko A.
europepmc +1 more source
Molecular Oncology, EarlyView.Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi +14 more
wiley +1 more source
Existence and regularity of a global attractor for doubly nonlinear parabolic equations
Electronic Journal of Differential Equations, 2002 In this paper we consider a doubly nonlinear parabolic partial differential equation $$ frac{partial eta (u)}{partial t}-Delta _{p}u+f(x,t,u)=0 quad hbox{in }Omega imesmathbb{R}^{+}, $$ with Dirichlet boundary condition and initial data given.
Abderrahmane El Hachimi, Hamid El Ouardi
doaj
Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source