Results 71 to 80 of about 10,151,897 (282)

CLRe: A Synergistic Dual‐Engine Framework for One‐Step Retrosynthesis Prediction

Advanced Science, EarlyView.
CLRe uses a contrastive difficulty score to order pretrained seq2seq fine‐tuning for retrosynthesis. Reaction embeddings define the ranking score, and a cumulative easy‐to‐hard schedule expands from the easiest subset to the full training set while earlier examples remain active.
Tianhao Su, Xitao Wang, Musen Li, Guanhua Qin, Shunbo Hu, Tong‐Yi Zhang   +5 more
wiley   +1 more source

An Industrial Organization Theory of Risk Sharing [PDF]

Examining the global reinsurance market for catastrophic losses, we propose a new theory of optimal risk sharing that finds its inspiration in the economic theory of the firm.
M. Martin Boyer, Charles M. Nyce
core  

Stress Hyperglycemia Drives CD4+ T Cell PANoptosis and Postoperative Organ Injury via Monocyte‐Derived Succinate

Advanced Science, EarlyView.
High glucose is linked to reduced succinate dehydrogenase activity in CD14+ monocytes, accompanied by succinate accumulation and extracellular release. Extracellular succinate exacerbates mitochondrial ROS production and mtDNA release in CD4+ T cells. Cytosolic mtDNA then activates Z‐DNA binding protein 1 (ZBP1) and engages ZBP1‐associated inflammatory
Shuai Zhao, Xuemei Miao, Wei Luo, Tao Liu, Yang Wang, Jiaying Li, Di Fu, Weiyun Shen, Yan Luo, Kang Chen, Ruping Dai, Hui Li   +11 more
wiley   +1 more source

Chimeric IL‐6/4R‐LL37 Engineered Macrophages Achieve Synchronized Inflammation Control and Antimicrobial Defence in Sepsis

Advanced Science, EarlyView.
Engineered macrophages programmed in situ by LNP‐delivered IL‐6/4 fusion and LL37 mRNAs simultaneously dampen cytokine storm, promote M2‐like repair, and enhance direct bacterial killing in sepsis. This combinatorial strategy restores T cell and macrophage function, lowers organ bacterial burden, and improves survival, highlighting a precision, host ...
Tianyang Jie, Zheyu Zhang, Hao Zhang, Linke Bian, Penglong Zheng, Sijia Zhou, Minqi Wang, Mingyu Qu, Yufei Wang, Xinhua Qu, Bing Yue   +10 more
wiley   +1 more source

The state of global catastrophic risk research: a bibliometric review

Earth System Dynamics
Abstract. The global catastrophic risk (GCR) and existential risk (ER) literature focuses on analyzing and preventing potential major global catastrophes including a human extinction event. Over the past two decades, the field of GCR/ER research has grown considerably. However, there has been little meta-research on the field itself. How large has this
Jehn, Florian Ulrich, Engler, John-Oliver, Arnscheidt, Constantin, Wache, Magdalena, Ilin, Ekaterina, Cook, Laura, Sundaram, Lalitha S., Hanusch, Frederic, Kemp, Luke   +8 more
openaire   +1 more source

Battery‐Inspired Electrochemical Synapses for Neuromorphic Applications

Advanced Science, EarlyView.
Battery‐ion‐inspired synaptic devices integrate diverse electrolyte systems (solid, ion‐gel, liquid) with transition metal oxides, two‐dimensional materials, and organic channels to regulate ion‐electron coupling. By tailoring ion transport and host interactions, these platforms enable controllable plasticity and energy‐efficient implementations for ...
Won Woo Lee, SeongCheol Jang, Wangmyung Choi, Jaewon Park, Jaehyun Hur, Hocheon Yoo, Hyun‐Suk Kim   +6 more
wiley   +1 more source

Wildfire Risk Mitigation through Systems Analysis of the Planetary Emergency

ASCE Open
Recognizing wildfires as a multiscale planetary emergency, this paper describes a systems analysis of technology countermeasures, with special attention to Sicily, California, and several other regions.
James H. Lambert, R. Ranger Dorn, Bilal M. Ayyub, William A. Barletta, John F. Organek, Marco Piras, Megan E. Gunn, S. Fabrizio Zichichi   +7 more
doaj   +1 more source

Asteroids: Assessing Catastrophic Risks

Journal of Probability and Statistics, 2010
We evaluate two risk profiles: (i) global warming risks and (ii) collisions with asteroids that can cause the extinction of our species. The expected values computed for these two risks suggest that no action will be taken to avoid extinction. The result
Graciela Chichilnisky, Peter Eisenberger
doaj   +1 more source

Financial risk of seeking maternal and neonatal healthcare in southern Ethiopia: a cohort study of rural households

International Journal for Equity in Health, 2020
Introduction Ethiopian households’ out-of-pocket healthcare payments constitute one-third of the national healthcare budget and are higher than the global and low-income countries average, and even the global target.
Moges Tadesse Borde, Eskindir Loha, Kjell Arne Johansson, Bernt Lindtjørn   +3 more
doaj   +1 more source

CLIMATE POLICY WHEN THE DISTANT FUTURE MATTERS: CATASTROPHIC EVENTS WITH HYPERBOLIC DISCOUNTING [PDF]

Low probability catastrophic climate change can have a signifcant influence on policy under hyperbolic discounting. We compare the set of Markov Perfect Equilibria (MPE) to the optimal policy under time-consistent commitment.
Tsur, Yacov, Karp, Larry S.
core