Results 131 to 140 of about 6,720,476 (300)

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Change Detection: Paying Attention To Detail Detail [PDF]

, 2000
Changes made during a brief visual interruption sometimes go undetected, even when the object undergoing the change is at the center of the observer's interest and spatial attention (Simons & Levin, 1998).
Austen, Erin, Enns, James T.
core  

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Climate vulnerability and adaptation pathways among smallholder sheep farmers in the Drakensberg Grasslands of South Africa

Frontiers in Climate
This study assesses climate exposure, sensitivity, and adaptive capacity among smallholder sheep farmers in the Drakensberg Grasslands of the Eastern Cape, South Africa. A mixed-methods approach combining focus group discussions (n = 89 participants) and
Mhlangabezi Slayi, Shadreck Muchaku, Hlekani Kabiti, Simbarashe Ndlevhe, Admire Rukudzo Dzvene   +4 more
doaj   +1 more source

Unintended Environmental Consequences of a Global Biofuels Program [PDF]

, 2009
and PDF report are also available on the MIT Joint Program on the Science and Policy of Global Change website (http://globalchange.mit.edu/).Biofuels are being promoted as an important part of the global energy mix to meet the climate change challenge ...
Cronin, Timothy W., Felzer, Benjamin Seth., Gurgel, Angelo C., Kicklighter, David W., Melillo, Jerry M., Paltsev, Sergey, Reilly, John M., Schlosser, C. Adam., Sokolov, Andrei P., Wang, Xiaodong   +9 more
core   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Analysis of Climate Policy Targets under Uncertainty [PDF]

, 2009
and PDF report are also available on the MIT Joint Program on the Science and Policy of Global Change website (http://globalchange.mit.edu/).Although policymaking in response to the climate change is essentially a challenge of risk management, most ...
Forest, Chris Eliot, Jacoby, Henry D., Kicklighter, David W., Melillo, Jerry M., Paltsev, Sergey, Prinn, Ronald G., Reilly, John M., Sarofim, Marcus C., Schlosser, C. Adam, Sokolov, Andrei P., Wang, Chien, Webster, Mort D.   +11 more
core   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Global Demographic Change: Dimensions and Economic Significance [PDF]

Transitions from high mortality and fertility to low mortality and fertility can be beneficial to economies as large baby boom cohorts enter the workforce and save for retirement, while rising longevity has perhaps increased both the incentive to invest ...
David Canning, David E. Bloom
core