Results 121 to 130 of about 12,171,189 (307)
, 2017 This report describes the status of the U.S. Global Change Research Program's research activities, provides progress updates, and documents recent ...
U.S. Global Change Research Program (2009- )
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Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
The Optimal Distribution of Surgery in Low- and Middle-Income Countries: A Proposed Matrix for Determining Country-Level Organization of Surgical Services – A Response to the Recent Commentaries [PDF]
International Journal of Health Policy and Management, 2022 Katherine R. Iverson +8 more
doaj +1 more source
FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source
Advancing Knowledge for Action on Global Environmental Change: Reflecting on Progress and Strategizing for the Future [PDF]
A report that discusses the company START which promotes knowledge on global environmental change in Africa and Asia-Pacific.
Global Change SysTem for Analysis, Research and Training
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FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Our changing planet : the FY ... research plan
, 1992 Annual report of the U.S. Global Change Research Program documenting activities and progress, goals for the upcoming year, proposed budget considerations, and other information about the organization for fiscal year ...
U.S. Global Change Research Program
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The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
2012-2017 Strategic Plan Progress Report
reportThe Global Change & Sustainability Center (GCSC) was established on the premise that solutions to the grand challenges facing society require the best thinking from multiple perspectives and disciplines.
Global Change & Sustainability Center
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FEBS Letters, EarlyView.Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil +3 more
wiley +1 more source