Results 121 to 130 of about 11,636,692 (262)

Our changing planet : the FY ... research plan

, 1992
Annual report of the U.S. Global Change Research Program documenting activities and progress, goals for the upcoming year, proposed budget considerations, and other information about the organization for fiscal year ...
U.S. Global Change Research Program
core  

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Advancing Knowledge for Action on Global Environmental Change: Reflecting on Progress and Strategizing for the Future [PDF]

A report that discusses the company START which promotes knowledge on global environmental change in Africa and Asia-Pacific.
Global Change SysTem for Analysis, Research and Training
core  

Environmental response to Lateglacial climate change. Reconstructions of temperature and vegetation changes in northwest Europe [PDF]

, 2012
The Weichselian Lateglacial (~14.7-11.7 ka BP) is marked by major climatic and environmental changes in the North Atlantic region. The long-term warming trend arising during the Lateglacial was interrupted by a number of rapid climate oscillations ...
FG Kusten, Rivieren, Global Change, Coastal dynamics, Fluvial systems and Global change, van Asch, N.   +2 more
core  

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Climate vulnerability and adaptation pathways among smallholder sheep farmers in the Drakensberg Grasslands of South Africa

Frontiers in Climate
This study assesses climate exposure, sensitivity, and adaptive capacity among smallholder sheep farmers in the Drakensberg Grasslands of the Eastern Cape, South Africa. A mixed-methods approach combining focus group discussions (n = 89 participants) and
Mhlangabezi Slayi, Shadreck Muchaku, Hlekani Kabiti, Simbarashe Ndhleve, Admire Rukudzo Dzvene   +4 more
doaj   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Human dimensions of global environmental change: A review of frameworks and research gaps. [PDF]

, 2005
This review of current knowledge in, and development of, priorities for research into the human dimensions of global environmental change has been conducted to assist the Foundation for Research Science and Technology to formulate their research needs ...
Gillespie, Alexander, Campbell, John, Scrimgeour, Frank, Urich, Peter   +3 more
core  

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

A Supplement to the President's Budget for Fiscal Year 2011

, 2011
Annual report of the U.S. Climate Change Science Program documenting activities and research, goals for the upcoming year, proposed budget considerations, and other information about the organization for fiscal year ...
Climate Change Science Program (U.S.)
core